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1.17.4.2: ribonucleoside-triphosphate reductase (thioredoxin)

This is an abbreviated version!
For detailed information about ribonucleoside-triphosphate reductase (thioredoxin), go to the full flat file.

Word Map on EC 1.17.4.2

Reaction

2'-deoxyribonucleoside 5'-triphosphate
+
thioredoxin disulfide
 +
H2O
=
ribonucleoside 5'-triphosphate
 +
thioredoxin

Synonyms

2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase, adenosylcobalamin-dependent ribonucleoside-triphosphate reductase, class Ib ribonucleotide reductase, class Ib RNR, class II ribonucleotide reductase, class II RNR, class III ribonucleotide reductase, class III RNR, More, nrdD, nucleoside triphosphate reductase, ribonucleoside triphosphate reductase, ribonucleotide diphosphate reductase, ribonucleotide reductase, RNR, RNR class Ia, RNR2, RTPR

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.4 With a disulfide as acceptor
                1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)

KI Value

KI Value on EC 1.17.4.2 - ribonucleoside-triphosphate reductase (thioredoxin)

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0143 - 0.0208
cob(II)alamin
0.0426
cyanocobalamin
-
-
0.0558
[3-(adenosin-5'-O-yl)propyl]cobalamin
-
-
0.0189
[4-(adenosin-5'-O-yl)butyl]cobalamin
-
-
0.0077
[5-(adenosin-5'-O-yl)pentyl]cobalamin
-
-
0.0246
[6-(adenosin-5'-O-yl)hexyl]cobalamin
-
-
0.0128
[7-(adenosin-5'-O-yl)heptyl]cobalamin
-
-
additional information
additional information
-
inhibition kinetics with gemcitabine
-