1.17.4.2: ribonucleoside-triphosphate reductase (thioredoxin)
This is an abbreviated version!
For detailed information about ribonucleoside-triphosphate reductase (thioredoxin), go to the full flat file.
Word Map on EC 1.17.4.2
-
1.17.4.2
-
hydroxyurea
-
deoxyribonucleotides
-
dntp
-
rr
-
herpes
-
tyrosyl
-
simplex
-
gemcitabine
-
leukemia
-
reductases
-
thymidine
-
thioredoxins
-
deoxycytidine
-
deoxynucleotides
-
cdp
-
s-phase
-
thymidylate
-
thiosemicarbazone
-
glutaredoxins
-
checkpoint
-
nsclc
-
cytidine
-
diferric
-
deoxyadenosine
-
diiron
-
fork
-
deoxyguanosine
-
5'-diphosphate
-
nonidentical
-
gallium
-
antiferromagnetically
-
hyperfine
-
proton-coupled
-
dinuclear
-
oncolytic
-
cross-complementation
-
acyclovir
-
cladribine
-
chk1
-
thiyl
-
aphidicolin
-
cross-complementing
-
endor
-
fludarabine
-
b12-dependent
-
gemcitabine-based
-
deoxythymidine
-
analysis
-
gemcitabine-induced
-
high-valent
-
peroxo
- 1.17.4.2
- hydroxyurea
- deoxyribonucleotides
- dntp
- rr
- herpes
-
tyrosyl
- simplex
- gemcitabine
- leukemia
- reductases
- thymidine
- thioredoxins
- deoxycytidine
-
deoxynucleotides
- cdp
-
s-phase
- thymidylate
- thiosemicarbazone
- glutaredoxins
-
checkpoint
-
nsclc
- cytidine
-
diferric
- deoxyadenosine
-
diiron
-
fork
- deoxyguanosine
- 5'-diphosphate
-
nonidentical
- gallium
-
antiferromagnetically
-
hyperfine
-
proton-coupled
-
dinuclear
-
oncolytic
-
cross-complementation
- acyclovir
- cladribine
- chk1
-
thiyl
- aphidicolin
-
cross-complementing
-
endor
- fludarabine
-
b12-dependent
-
gemcitabine-based
- deoxythymidine
- analysis
-
gemcitabine-induced
-
high-valent
-
peroxo
Reaction
Synonyms
2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase, adenosylcobalamin-dependent ribonucleoside-triphosphate reductase, class Ib ribonucleotide reductase, class Ib RNR, class II ribonucleotide reductase, class II RNR, class III ribonucleotide reductase, class III RNR, More, nrdD, nucleoside triphosphate reductase, ribonucleoside triphosphate reductase, ribonucleotide diphosphate reductase, ribonucleotide reductase, RNR, RNR class Ia, RNR2, RTPR
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Substrates Products
Substrates Products on EC 1.17.4.2 - ribonucleoside-triphosphate reductase (thioredoxin)
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REACTION DIAGRAM
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
ribonucleoside triphosphate + reduced thioredoxin
-
-
-
-
r
nucleoside 5'-triphosphate + thioredoxin
2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
ribonucleoside triphosphate + 2-hydroxyethyl disulfide
2'-deoxyribonucleoside triphosphate + 2-mercaptoethanol + H2O
-
-
-
-
?
ribonucleoside triphosphate + dihydrolipoate
2'-deoxyribonucleoside triphosphate + lipoate + H2O
ribonucleoside triphosphate + dithioerythritol
2'-deoxyribonucleoside triphosphate + ? + H2O
ribonucleoside triphosphate + dithiothreitol
2'-deoxyribonucleoside triphosphate + ? + H2O
ribonucleoside triphosphate + NADP+
2'-deoxyribonucleoside triphosphate + NADPH + H2O
-
-
-
-
?
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
ribonucleoside triphosphate + reduced thioredoxin
deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
ribonucleoside triphosphate + thioredoxin
2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O
-
-
-
-
?
ADP + reduced thioredoxin
dADP + oxidized thioredoxin + H2O
-
-
-
-
?
ADP + reduced thioredoxin
dADP + oxidized thioredoxin + H2O
-
-
-
-
?
ADP + reduced thioredoxin
dADP + oxidized thioredoxin + H2O
-
most active diphosphate substrate
-
-
?
ATP + reduced thioredoxin
dATP + oxidized thioredoxin + H2O
-
-
-
-
?
ATP + reduced thioredoxin
dATP + oxidized thioredoxin + H2O
-
-
-
-
?
ATP + reduced thioredoxin
dATP + oxidized thioredoxin + H2O
-
-
-
-
?
dCDP + oxidized dithiothreitol + H2O
-
-
-
-
r
CDP + reduced dithiothreitol
dCDP + oxidized dithiothreitol + H2O
-
-
-
-
?
CDP + reduced dithiothreitol
dCDP + oxidized dithiothreitol + H2O
Priestia megaterium KM / ATCC 13632
-
-
-
-
?
dCDP + oxidized thioredoxin + H2O
-
-
-
-
?
CDP + reduced thioredoxin
dCDP + oxidized thioredoxin + H2O
Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539
-
-
-
-
?
CDP + reduced thioredoxin
dCDP + oxidized thioredoxin + H2O
-
-
-
-
?
CDP + reduced thioredoxin
dCDP + oxidized thioredoxin + H2O
-
-
-
-
?
CDP + reduced thioredoxin
dCDP + oxidized thioredoxin + H2O
-
poorly reduced
-
-
?
CDP + reduced thioredoxin
dCDP + oxidized thioredoxin + H2O
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
-
-
-
-
?
dCMP + oxidized thioredoxin + H2O
-
-
-
-
?
CMP + reduced thioredoxin
dCMP + oxidized thioredoxin + H2O
-
poorly reduced
-
-
?
CTP + reduced thioredoxin
dCTP + oxidized thioredoxin + H2O
-
-
-
-
?
CTP + reduced thioredoxin
dCTP + oxidized thioredoxin + H2O
-
-
-
-
?
CTP + reduced thioredoxin
dCTP + oxidized thioredoxin + H2O
Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539
-
-
-
-
?
CTP + reduced thioredoxin
dCTP + oxidized thioredoxin + H2O
-
-
-
-
?
CTP + reduced thioredoxin
dCTP + oxidized thioredoxin + H2O
-
-
-
-
?
CTP + reduced thioredoxin
dCTP + oxidized thioredoxin + H2O
-
-
-
?
CTP + reduced thioredoxin
dCTP + oxidized thioredoxin + H2O
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
-
-
-
-
?
CTP + reduced thioredoxin
dCTP + thioredoxin disulfide + H2O
-
-
-
-
?
CTP + reduced thioredoxin
dCTP + thioredoxin disulfide + H2O
-
-
-
-
?
dGDP + oxidized thioredoxin + H2O
-
-
-
-
?
GDP + reduced thioredoxin
dGDP + oxidized thioredoxin + H2O
-
poorly reduced
-
-
?
GTP + reduced thioredoxin
dGTP + oxidized thioredoxin + H2O
-
-
-
-
?
GTP + reduced thioredoxin
dGTP + oxidized thioredoxin + H2O
-
-
-
-
?
GTP + reduced thioredoxin
dGTP + oxidized thioredoxin + H2O
-
-
-
-
?
2'-deoxynucleoside 5'-triphosphate + H2O
-
class III RNR
-
-
?
nucleoside 5'-triphosphate + formate
2'-deoxynucleoside 5'-triphosphate + H2O
Tequatrovirus T4
-
class III RNR
-
-
?
2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
-
class II RNRs
-
-
?
nucleoside 5'-triphosphate + thioredoxin
2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
-
class III RNR
-
-
?
nucleoside 5'-triphosphate + thioredoxin
2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
-
class II RNRs
-
-
?
nucleoside 5'-triphosphate + thioredoxin
2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
-
class III RNR
-
-
?
nucleoside 5'-triphosphate + thioredoxin
2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
-
class III RNR
-
-
?
2'-deoxyribonucleoside triphosphate + lipoate + H2O
-
-
-
-
?
ribonucleoside triphosphate + dihydrolipoate
2'-deoxyribonucleoside triphosphate + lipoate + H2O
-
-
-
-
?
ribonucleoside triphosphate + dihydrolipoate
2'-deoxyribonucleoside triphosphate + lipoate + H2O
-
-
-
-
?
2'-deoxyribonucleoside triphosphate + ? + H2O
-
-
-
-
?
ribonucleoside triphosphate + dithioerythritol
2'-deoxyribonucleoside triphosphate + ? + H2O
-
-
-
-
?
ribonucleoside triphosphate + dithioerythritol
2'-deoxyribonucleoside triphosphate + ? + H2O
-
-
-
-
?
ribonucleoside triphosphate + dithioerythritol
2'-deoxyribonucleoside triphosphate + ? + H2O
-
-
-
-
?
2'-deoxyribonucleoside triphosphate + ? + H2O
-
-
-
-
?
ribonucleoside triphosphate + dithiothreitol
2'-deoxyribonucleoside triphosphate + ? + H2O
-
-
-
-
?
ribonucleoside triphosphate + dithiothreitol
2'-deoxyribonucleoside triphosphate + ? + H2O
-
-
-
-
?
2'-deoxyribonucleoside triphosphate + GSH + H2O
-
-
-
-
?
ribonucleoside triphosphate + GSSG
2'-deoxyribonucleoside triphosphate + GSH + H2O
-
-
-
-
?
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
Astasia sp.
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
437887, 437888, 437889, 437890, 437891, 437892, 437893, 437894, 437896, 437897, 437898, 437899, 437900, 437901, 437902, 437903
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
Astasia sp.
-
-
-
-
?
ribonucleoside triphosphate + reduced thioredoxin
deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
?
ribonucleoside triphosphate + reduced thioredoxin
deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
?
ribonucleoside triphosphate + reduced thioredoxin
deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
?
ribonucleoside triphosphate + reduced thioredoxin
deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
?
ribonucleoside triphosphate + reduced thioredoxin
deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
?
ribonucleoside triphosphate + reduced thioredoxin
deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
?
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
Astasia sp.
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
key enzyme in the pathway of DNA biosynthesis in all organisms
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
437887, 437889, 437890, 437891, 437892, 437893, 437894, 437896, 437897, 437898, 437899, 437901, 437902, 437903
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
physiological hydrogen donor is unknown
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
catalyzes the rate-determining step in DNA biosynthesis
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
-
-
-
r
dUDP + oxidized thioredoxin + H2O
-
-
-
-
?
UDP + reduced thioredoxin
dUDP + oxidized thioredoxin + H2O
-
poorly reduced
-
-
?
UTP + reduced thioredoxin
dUTP + oxidized thioredoxin + H2O
-
-
-
-
?
UTP + reduced thioredoxin
dUTP + oxidized thioredoxin + H2O
-
-
-
-
?
UTP + reduced thioredoxin
dUTP + oxidized thioredoxin + H2O
-
-
-
-
?
?
-
the small subunit of RNR2 interacts in planta with the C-terminal section of signalosome protein complex COP9 subunit 7, CSN7, overview
-
-
?
additional information
?
-
the small subunit of RNR2 interacts in planta with the C-terminal section of signalosome protein complex COP9 subunit 7, CSN7, overview
-
-
?
additional information
?
-
the small subunit of RNR2 interacts in planta with the C-terminal section of signalosome protein complex COP9 subunit 7, CSN7, overview
-
-
?
additional information
?
-
the small subunit of RNR2 interacts in planta with the C-terminal section of signalosome protein complex COP9 subunit 7, CSN7, overview
-
-
?
additional information
?
-
-
class II RNRs convert nucleoside triphosphates and nucleoside 5'-diphosphates, see also EC 1.17.4.1, to the correspondent 2'-deoxy products, overview
-
-
?
additional information
?
-
-
In class II a tyrosine radical is generated directly on alpha or alpha2 by cleavage of adenosylcobalamin. In class III a glycyl radical is generated on alpha2 when a radical SAM protein cleaves S-adenosylmethionine. In both cases, the radical is channeled to a cysteine in the active site of the alpha subunit to initiate catalysis
-
-
?
additional information
?
-
-
the class II RNR also uses nucleoside 5'-diphosphate as substrate
-
-
?
additional information
?
-
-
the anaerobic ribonucleotide reductase of Escherichia coli is an essential enzyme required to supply the building blocks for DNA synthesis
-
-
?
additional information
?
-
-
p53-dependent small enzyme subunit M2B may play an important role for initiating DNA replication in normal growth
-
-
?
additional information
?
-
-
the enzyme produces deoxyribonucleotide triphosphates, dNTPs
-
-
?
additional information
?
-
-
the enzyme also catalyzes the exchange of the C5'-hydrogens of adenosylcobalamin with solvent hydrogen, epimerization of the (5'S)-[5'-2H1]- and (5'R)-[5'-2H1]-isotopomers of adenosylcobalamin
-
-
?
additional information
?
-
-
RTPR catalyzes the conversion of nucleoside triphosphates to deoxynucleotides requiring adenosylcobalamin as a cofactor, model of reaction mechanism, overview
-
-
?
additional information
?
-
-
RTPR catalyzes the conversion of nucleoside triphosphates to deoxynucleotides using adenosylcobalamin as a cofactor
-
-
?
additional information
?
-
-
class II RNRs convert nucleoside triphosphates and nucleoside 5'-diphosphates, see also EC 1.17.4.1, to the correspondent 2'deoxy products, overview
-
-
?
additional information
?
-
-
the class II RNR also uses nucleoside 5'-diphosphate as substrate
-
-
?
additional information
?
-
-
the two-component class II RNR is primarily used for DNA repair and/or possibly DNA replication at low oxygen tension. It can support bacterial growth in the absence of class I RNR activity
-
-
?
additional information
?
-
-
In class II a tyrosine radical is generated directly on alpha or alpha2 by cleavage of adenosylcobalamin. In class III a glycyl radical is generated on alpha2 when a radical SAM protein cleaves S-adenosylmethionine. In both cases, the radical is channeled to a cysteine in the active site of the alpha subunit to initiate catalysis
-
-
?
additional information
?
-
-
In class II a tyrosine radical is generated directly on alpha or alpha2 by cleavage of adenosylcobalamin. In class III a glycyl radical is generated on alpha2 when a radical SAM protein cleaves S-adenosylmethionine. In both cases, the radical is channeled to a cysteine in the active site of the alpha subunit to initiate catalysis
-
-
?