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1.17.4.2: ribonucleoside-triphosphate reductase (thioredoxin)

This is an abbreviated version!
For detailed information about ribonucleoside-triphosphate reductase (thioredoxin), go to the full flat file.

Word Map on EC 1.17.4.2

Reaction

2'-deoxyribonucleoside 5'-triphosphate
+
thioredoxin disulfide
+
H2O
=
ribonucleoside 5'-triphosphate
+
thioredoxin

Synonyms

2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase, adenosylcobalamin-dependent ribonucleoside-triphosphate reductase, class Ib ribonucleotide reductase, class Ib RNR, class II ribonucleotide reductase, class II RNR, class III ribonucleotide reductase, class III RNR, More, nrdD, nucleoside triphosphate reductase, ribonucleoside triphosphate reductase, ribonucleotide diphosphate reductase, ribonucleotide reductase, RNR, RNR class Ia, RNR2, RTPR

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.4 With a disulfide as acceptor
                1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)

Substrates Products

Substrates Products on EC 1.17.4.2 - ribonucleoside-triphosphate reductase (thioredoxin)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
ribonucleoside triphosphate + reduced thioredoxin
show the reaction diagram
-
-
-
-
r
ADP + reduced thioredoxin
dADP + oxidized thioredoxin + H2O
show the reaction diagram
ATP + reduced thioredoxin
dATP + oxidized thioredoxin + H2O
show the reaction diagram
CDP + reduced dithiothreitol
dCDP + oxidized dithiothreitol + H2O
show the reaction diagram
CDP + reduced thioredoxin
dCDP + oxidized thioredoxin + H2O
show the reaction diagram
CMP + reduced thioredoxin
dCMP + oxidized thioredoxin + H2O
show the reaction diagram
CTP + adenosylcobalamin
?
show the reaction diagram
-
-
-
-
?
CTP + reduced thioredoxin
dCTP + oxidized thioredoxin + H2O
show the reaction diagram
CTP + reduced thioredoxin
dCTP + thioredoxin disulfide + H2O
show the reaction diagram
dATP + adenosylcobalamin
?
show the reaction diagram
-
-
-
-
?
GDP + reduced thioredoxin
dGDP + oxidized thioredoxin + H2O
show the reaction diagram
GTP + reduced thioredoxin
dGTP + oxidized thioredoxin + H2O
show the reaction diagram
IDP + reduced thioredoxin
dIDP + oxidized thioredoxin
show the reaction diagram
-
-
-
-
?
ITP + reduced thioredoxin
dITP + oxidized thioredoxin
show the reaction diagram
-
-
-
-
?
nucleoside 5'-triphosphate + formate
2'-deoxynucleoside 5'-triphosphate + H2O
show the reaction diagram
nucleoside 5'-triphosphate + thioredoxin
2'-deoxynucleoside 5'-triphosphate + thioredoxin disulfide + H2O
show the reaction diagram
ribonucleoside triphosphate + 2-hydroxyethyl disulfide
2'-deoxyribonucleoside triphosphate + 2-mercaptoethanol + H2O
show the reaction diagram
-
-
-
-
?
ribonucleoside triphosphate + dihydrolipoate
2'-deoxyribonucleoside triphosphate + lipoate + H2O
show the reaction diagram
ribonucleoside triphosphate + dithioerythritol
2'-deoxyribonucleoside triphosphate + ? + H2O
show the reaction diagram
ribonucleoside triphosphate + dithiothreitol
2'-deoxyribonucleoside triphosphate + ? + H2O
show the reaction diagram
ribonucleoside triphosphate + GSSG
2'-deoxyribonucleoside triphosphate + GSH + H2O
show the reaction diagram
ribonucleoside triphosphate + NADP+
2'-deoxyribonucleoside triphosphate + NADPH + H2O
show the reaction diagram
-
-
-
-
?
ribonucleoside triphosphate + reduced thioredoxin
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
show the reaction diagram
ribonucleoside triphosphate + reduced thioredoxin
deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
show the reaction diagram
ribonucleoside triphosphate + reduced thioredoxin + H2O
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
show the reaction diagram
ribonucleoside triphosphate + thioredoxin
2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O
show the reaction diagram
-
-
-
-
?
UDP + reduced thioredoxin
dUDP + oxidized thioredoxin + H2O
show the reaction diagram
UMP + reduced thioredoxin
dUMP + oxidized thioredoxin + H2O
show the reaction diagram
-
-
-
-
?
UTP + reduced thioredoxin
dUTP + oxidized thioredoxin + H2O
show the reaction diagram
additional information
?
-