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1.17.4.4: vitamin-K-epoxide reductase (warfarin-sensitive)

This is an abbreviated version!
For detailed information about vitamin-K-epoxide reductase (warfarin-sensitive), go to the full flat file.

Word Map on EC 1.17.4.4

Reaction

phylloquinol
+
a protein with a disulfide bond
=
phylloquinone
 +
a protein with reduced L-cysteine residues

Synonyms

EC 1.1.4.1, phylloquinone epoxide reductase, reductase, phylloquinone epoxide, vitamin K 2,3-epoxide reductase, vitamin K 2,3-epoxide reductase complex subunit 1, vitamin K 2,3-epoxide reductase complex subunit-1, vitamin K epoxid reductase, vitamin K epoxide reductase, vitamin K epoxide reductase complex subunit 1, vitamin K oxidoreductase, Vitamin K reductase, vitamin K-2,3-epoxide reductase, vitamin K-2,3-epoxide reductase subunit 1, vitamin K-epoxide reductase, vitamin K1 epoxide reductase, vitaminK epoxide reductase, VKOR, VKOR complex, VKORC1, VKORC1 variant 2, VKORC1-like 1, VKORC1L1, VKORC1v2, warfarin sensitive vitamin K 2,3-epoxide reductase, warfarin-sensitive vitamin K1 2,3-epoxide reductase

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.4 With a disulfide as acceptor
                1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive)

Source Tissue

Source Tissue on EC 1.17.4.4 - vitamin-K-epoxide reductase (warfarin-sensitive)

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
mainly in vascular endothelium
Manually annotated by BRENDA team
-
dermal, low expression rate
Manually annotated by BRENDA team
low expression level
Manually annotated by BRENDA team
B lymphocyte, measurement of allelic mRNA expression
Manually annotated by BRENDA team
highest expression in muscle and brain
Manually annotated by BRENDA team
highly expressed
Manually annotated by BRENDA team
-
adult
Manually annotated by BRENDA team
low expression level
Manually annotated by BRENDA team
intermediate level of expresssion
Manually annotated by BRENDA team
low level of expression
Manually annotated by BRENDA team
additional information
-
quantitative expression analysis, no enzyme expression in peripheral blood leukocytes, the enzyme is upregulated in tumour tissue, overview
Manually annotated by BRENDA team