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1.17.4.5: vitamin-K-epoxide reductase (warfarin-insensitive)

This is an abbreviated version!
For detailed information about vitamin-K-epoxide reductase (warfarin-insensitive), go to the full flat file.

Word Map on EC 1.17.4.5

Reaction

3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone
+
oxidized dithiothreitol
=
2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone
+
1,4-dithiothreitol

Synonyms

EC 1.1.4.2, non-VKOR, reductase, vitamin K epoxide (warfarin-insensitive), vitamin K 2,3 epoxide reductase, vitamin K epoxide reductase, vitamin K epoxide reductase (warfarin-insensitive), vitamin K epoxide reductase-like1, vitamin KO reductase, VKOR, VKOR-like1, VKORC1L1, VKORL1

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.4 With a disulfide as acceptor
                1.17.4.5 vitamin-K-epoxide reductase (warfarin-insensitive)

IC50 Value

IC50 Value on EC 1.17.4.5 - vitamin-K-epoxide reductase (warfarin-insensitive)

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00007
brodifacoum
Rattus norvegicus
-
mutant Y137F, pH 7.4, 37°C
0.00061
bromadiolone
Rattus norvegicus
-
mutant Y137F, pH 7.4, 37°C
0.0016
chlorophacinone
Rattus norvegicus
-
mutant Y137F, pH 7.4, 37°C
0.0001
Difenacoum
Rattus norvegicus
-
mutant Y137F, pH 7.4, 37°C
0.00005
difethialone
Rattus norvegicus
-
mutant Y137F, pH 7.4, 37°C