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1.17.4.5: vitamin-K-epoxide reductase (warfarin-insensitive)

This is an abbreviated version!
For detailed information about vitamin-K-epoxide reductase (warfarin-insensitive), go to the full flat file.

Word Map on EC 1.17.4.5

Reaction

3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone
+
oxidized dithiothreitol
=
2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone
+
1,4-dithiothreitol

Synonyms

EC 1.1.4.2, non-VKOR, reductase, vitamin K epoxide (warfarin-insensitive), vitamin K 2,3 epoxide reductase, vitamin K epoxide reductase, vitamin K epoxide reductase (warfarin-insensitive), vitamin K epoxide reductase-like1, vitamin KO reductase, VKOR, VKOR-like1, VKORC1L1, VKORL1

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.4 With a disulfide as acceptor
                1.17.4.5 vitamin-K-epoxide reductase (warfarin-insensitive)

Systematic Name

Systematic Name on EC 1.17.4.5 - vitamin-K-epoxide reductase (warfarin-insensitive)

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SYSTEMATIC NAME
IUBMB Comments
3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase
Vitamin K 2,3-epoxide is reduced to 3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithiothreitol, which is oxidized to a disulfide. Not inhibited by warfarin [cf. EC 1.17.4.4, vitamin-K-epoxide reductase (warfarin-sensitive)].