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1.17.7.3: (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)

This is an abbreviated version!
For detailed information about (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin), go to the full flat file.

Word Map on EC 1.17.7.3

Reaction

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate
+
H2O
 +
oxidized flavodoxin
=
2-C-methyl-D-erythritol 2,4-cyclodiphosphate
 +
reduced flavodoxin

Synonyms

(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating), (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase, 2-C-methyl-D-erythritol-2,4-cyclodiphosphate reductase, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, GcpE, HMBPP synthase, IspG

ECTree

     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.7 With an iron-sulfur protein as acceptor
                1.17.7.3 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)

Engineering

Engineering on EC 1.17.7.3 - (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C270S
the replacement of any of the three conserved cysteine residues affords mutant proteins which are devoid of catalytic activity and contain less than 6% of Fe2+ and less than 23% of S2- as compared to the wild-type protein
C273S
the replacement of any of the three conserved cysteine residues affords mutant proteins which are devoid of catalytic activity and contain less than 6% of Fe2+ and less than 23% of S2- as compared to the wild-type protein
C306S
the replacement of any of the three conserved cysteine residues affords mutant proteins which are devoid of catalytic activity and contain less than 6% of Fe2+ and less than 23% of S2- as compared to the wild-type protein