1.17.99.3: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase

This is an abbreviated version!
For detailed information about 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase, go to the full flat file.

Reaction

Synonyms

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase, alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase, THC-CoA oxidase, THCA-CoA oxidase, THCCox, Trihydroxycoprostanoyl-CoA oxidase

ECTree

     1 Oxidoreductases

         1.17 Acting on CH or CH₂ groups

             1.17.99 With unknown physiological acceptors

                1.17.99.3 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase

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8	Activating Compound
6	AA Sequence
2	CAS Registry Number
2	Cloned(Commentary)
3	Cofactor
1	General Stability
3	Inhibitors
8	Localization
5	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
6	Organic Solvent Stability
12	Organism
2	Pathway
1	pH Optimum
1	pH Range
1	pI Value
3	Purification (Commentary)
1	Reaction
6	Reaction Type
12	Reference
11	Source Tissue
2	Specific Activity [micromol/min/mg]
10	Substrates and Products (Substrate)
2	Subunits
15	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 1.17.99.3 - 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor

(24R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor

Rattus norvegicus

-

the 25S epimer is a preferential substrate

660513

-

-

?

(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor

3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor

Rattus norvegicus

-

-

658691

-

-

?

(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA + H2O + acceptor

(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-27-oic acid + reduced acceptor

Oryctolagus cuniculus

-

no activity with (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA

657715

-

-

?

2-methylhexanoyl-CoA + H2O + acceptor

3-hydroxy-2-methylhexanoyl-CoA + reduced acceptor

Rattus norvegicus

-

-

657798

-

-

?

2-methylpalmitoyl-CoA + H2O + acceptor

3-hydroxy-2-methylhexandecanoyl-CoA + reduced acceptor

Rattus norvegicus

-

-

657798

-

-

?

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor

3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor

Rattus norvegicus

-

conversion of the coenzyme A ester is lower than with the free acid as substrate

659114

-

-

?

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid + H2O + acceptor

3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoic acid + reduced acceptor

Rattus norvegicus

-

-

659114

-

-

?

pristanoyl-CoA + H2O + acceptor

3-hydroxy-1,6,10,14-tetramethylpentadecanoyl-CoA + reduced acceptor

Rattus norvegicus

-

-

657798

-

-

?

trihydroxycoprostanoyl-CoA + H2O + acceptor

3alpha,7alpha,12alpha,24-tetrahydroxycoprostanoyl-CoA + reduced acceptor

Rattus norvegicus

-

-

657798

-

-

?

additional information

?

-

Rattus norvegicus

-

noninducible enzyme

391048

-

-

?