1.17.99.4: uracil/thymine dehydrogenase

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For detailed information about uracil/thymine dehydrogenase, go to the full flat file.

Reaction

Synonyms

dehydrogenase, uracil, EC 1.1.99.19, EC 1.2.99.1, uracil dehydrogenase, uracil oxidase, uracil-thymidine oxidase

ECTree

1 Oxidoreductases

1.17 Acting on CH or CH₂ groups

1.17.99 With unknown physiological acceptors

1.17.99.4 uracil/thymine dehydrogenase

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Results	in table
4	Activating Compound
1	CAS Registry Number
4	Cofactor
1	General Stability
2	KM Value [mM]
6	Localization
5	Natural Substrates/ Products (Substrates)
10	Organism
3	Pathway
1	pH Optimum
2	pH Range
2	pH Stability
2	Reaction
9	Reaction Type
8	Reference
1	Specific Activity [micromol/min/mg]
2	Storage Stability
24	Substrates and Products (Substrate)
11	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 1.17.99.4 - uracil/thymine dehydrogenase

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uracil:acceptor oxidoreductase

Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 3.5.2.1 (barbiturase) and EC 3.5.1.95 (N-malonylurea hydrolase). Mammals, plants and other microorganisms utilize the reductive pathway, comprising EC 1.3.1.1 [dihydrouracil dehydrogenase (NAD+)] or EC 1.3.1.2 [dihydropyrimidine dehydrogenase (NADP+)], EC 3.5.2.2 (dihydropyrimidinase) and EC 3.5.1.6 (beta-ureidopropionase), with the ultimate degradation products being an L-amino acid, NH3 and CO2 [5].