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1.18.1.2: ferredoxin-NADP+ reductase

This is an abbreviated version!
For detailed information about ferredoxin-NADP+ reductase, go to the full flat file.

Word Map on EC 1.18.1.2

Reaction

2 reduced ferredoxin +

NADP+
+
H+
= 2 oxidized ferredoxin +
NADPH

Synonyms

ABO_0145, adrenodoxin reductase, AnFNR, BsFNR, CT1512, cytochrome b6f -associated ferredoxin:NADP+ oxidoreductase, DA1, EC 1.6.7.1, EC 1.6.99.4, Fd-NADP+ reductase, ferredoxin (flavodoxin)-(reduced) nicotinamide adenine dinucleotide phosphate reductase, ferredoxin (flavodoxin)-NAD(P)H reductase, ferredoxin (flavodoxin)-NADP(H) reductase, ferredoxin (flavodoxin):NADP+ oxidoreductase, ferredoxin NADP oxidoreductase, ferredoxin NADP reductase, ferredoxin NADP(H) oxidoreductase, ferredoxin NADP+ oxidoreductase, ferredoxin NADP+ reductase, ferredoxin nicotinamide adenine dinucleotide phosphate reductase, ferredoxin-NAD(P)+ oxidoreductase, ferredoxin-NAD(P)+ reductase, ferredoxin-NAD(P)H reductase, ferredoxin-NADP oxidoreductase, ferredoxin-NADP reductase, Ferredoxin-NADP(+) reductase, ferredoxin-NADP(H) oxidoreductase, ferredoxin-NADP(H) reductase, ferredoxin-NADP+ oxidoreductase, ferredoxin-NADP+ reductase, ferredoxin-NADP+-oxidoreductase, ferredoxin-NADP+-reductase, ferredoxin-NADP-oxidoreductase, ferredoxin-NADP-reductase, ferredoxin-nicotinamide adenine dinucleotide phosphate reductase, ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase, ferredoxin-TPN reductase, ferredoxin: NADP(+) oxidoreductase, ferredoxin: NADP+ oxidoreductase, ferredoxin:NADP oxidoreductase, ferredoxin:NADP(+) oxidoreductase, ferredoxin:NADP(H) oxidoreductase, ferredoxin:NADP(H) oxidoreductase 2, ferredoxin:NADP+ oxidoreductase, ferredoxin:NADP+ reductase, ferredoxin:NADPH oxidoreductase, ferric reductase, Flavodoxin reductase, FLDR, FLXR, FNR, FNR-A, FNR-B, FNR1, FNR2, FNRII, FNRL, FNRS, FPR, FprA, FprB, Fprs, LFNR1, LFNR2, mitochondrial-type ferredoxin:NADP+ reductase, More, mtFNR, NADH-dependent reduced ferredoxin:NADP oxidoreductase, NADP:ferredoxin oxidoreductase, NADPH ferredoxin reductase, NADPH-dependent ferredoxin reductase, NADPH:ferredoxin oxidoreductase, NfnAB, NfnIII, NFR, PETH, PfFNR, pFNR, photosynthetic ferredoxin NADP+ oxidoreductase, photosynthetic FNR, plastidic-type ferredoxin-NADP+ reductase, PP4_41290, RcFPR, reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase, reductase, ferredoxin-nicotinamide adenine dinucleotide phosphate, RFNR2, ST2133, TgFNR, TPNH-ferredoxin reductase, YumC

ECTree

     1 Oxidoreductases
         1.18 Acting on iron-sulfur proteins as donors
             1.18.1 With NAD+ or NADP+ as acceptor
                1.18.1.2 ferredoxin-NADP+ reductase

Inhibitors

Inhibitors on EC 1.18.1.2 - ferredoxin-NADP+ reductase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2E,6E)-2,6-bis[(thiophen-2-yl)methylidene]cyclohexan-1-one
-
-
(E)-([[5-(5-bromothiophen-2-yl)-1,3-thiazol-2-yl]amino]methylidene)amino 4-nitrobenzoate
-
-
1,3-dichloro-2-(4-nitrophenoxy)benzene
-
-
1-(2,6-dimethylphenyl)-3-thiophen-2-ylurea
-
-
1-(3-chloro-4-fluoro-phenyl)-3-(3-chloro-phenyl)-urea
-
-
1-(3-chloro-4-fluorophenyl)-3-[3-(4-chlorophenyl)-4-cyano-5-(methylsulfanyl)thiophen-2-yl]urea
-
-
1-[3-[([[(4Z)-3,4-dihydro-1H-2-benzothiopyran-4-ylidene]amino]oxy)methyl]-4-methoxyphenyl]ethan-1-one
-
-
1-[5-(4-chloro-benzylsulfanyl)-[1,3,4]thiadiazol-2-yl]-3-(4-chloro-phenyl)-urea
-
-
2',5'-ADP
2',5'-ATP-ribose
-
competitive inhibition, competitive in forming complexes with reductase
2'-AMP
2-(4-bromothiophen-2-yl)-1,3-dithiolane
-
-
2-(benzylamino)-2-(3,4-dichlorophenyl)acetonitrile
-
-
2-(benzylsulfanyl)-5-chloro-1,3-benzothiazole
-
-
2-([2-[(2-aminophenyl)sulfanyl]-6-nitro-4-(trifluoromethyl)phenyl]sulfanyl)aniline
-
-
2-amino-4-(4-chlorophenyl)-9-fluoro-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile
-
-
2-chloro-6H-5-thia-7-azatetraphene-12-carboxylic acid
-
-
2-oxo-2-phenylethyl 3-iodobenzoate
-
-
2-phenyl-1,2-benzoselenazol-3-one
-
-
2-[4-(4-chlorophenyl)-2H-1,3-dithiol-2-ylidene]propanedinitrile
-
-
3,5-diethyl 4-[5-[2-chloro-5-(trifluoromethyl)phenyl]furan-2-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
-
-
3-(1-ethynylcyclohexyl)-1-(6-[[(1-ethynylcyclohexyl)carbamoyl]amino]hexyl)urea
-
-
3-(3-chlorophenyl)-1-[2-(thiophene-2-sulfonamido)phenyl]urea
-
-
3-(3-chlorophenyl)-4-cyano-5-(methylsulfanyl)thiophene-2-carboxylic acid
-
-
3-(5-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)-N'-[3-(thiophen-2-yl)-1,2,4-oxadiazole-5-carbonyl]propanehydrazide
-
-
3-amino-5-[(cyanomethyl)sulfanyl]-4-(propane-2-sulfonyl)thiophene-2-carbonitrile
-
-
3-[3-[(2,4-dichlorophenyl)sulfanyl]-3-oxopropyl]-2,3-dihydro-1,3-benzoxazol-2-one
-
-
4-(1,3-dithiolan-2-yl)-2-methoxy-6-nitrophenyl 2,5-dichlorobenzene-1-sulfonate
-
-
4-(2-fluorophenyl)-N,N-bis(propan-2-yl)benzamide
-
-
4-(4-chlorobenzenesulfonyl)-N-(2,4-difluorophenyl)-3-methylthiophene-2-carboxamide
-
-
4-amino-3,5-dichloro-N-(2,4,5-trichlorophenyl)benzamide
-
-
4-bromo-3-[(1E)-[2-(2,4-dichlorophenyl)hydrazin-1-ylidene]methyl]-1-methyl-1H-pyrazole
-
-
4-cyclohexyl-2-[[(2,5-dimethylphenyl)methyl]sulfanyl]-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
-
-
5-methyl-4-phenyl-N-([[3-(trifluoromethyl)phenyl]carbamoyl]amino)-1,3-oxazole-2-carboxamide
-
-
adenosine 2',5'-diphosphate
-
-
benzalkonium chloride
-
-
benzethonium chloride
-
-
Butanedione
-
inhibitor of transhydrogenase and diaphorase activity, reacts with arginine residue involved in binding of pyridine nucleotides
diphosphate
-
inhibitor of ferredoxin-dependent photoreduction
disulfodisalicylidenepropane-1,1-diamine
-
inhibits all reactions except photoreduction of cytochrome c
Dithionite
-
-
ethyl 2-[3-(3,4,5-trimethoxyphenyl)propanamido]acetate
-
-
ethyl 5-benzamido-4-cyano-3-methyl-1-phenyl-1H-pyrrole-2-carboxylate
-
-
Ferredoxin
-
flavodoxinI/II
inhibition of electron transfer at higher electron acceptor rate
-
guanidine hydrochloride
-
0.1 M guanidine hydrochloride reduces activity by 30%, 0.2 M guanidine hydrochloride by 60%, and 0.4 M guanidine hydrochloride by 85%, concentrations over 0.7 M guanidine hydrochloride eliminate activity
heparin
-
binds to the enzyme, inhibits ferredoxin and NADPH binding to the enzyme
iodoacetamide
Mercurials
-
-
-
methyl 3-[2-(thiophen-2-yl)acetamido]thiophene-2-carboxylate
-
-
Mg2+
-
inhibits reduction of plastoquinone incorporated into sodium cholate micelles
MgCl2
-
inhibits at lower salt concentrations
myristyltrimethylammonium bromide
-
inhibits reduction of plastoquinone almost completely at 15 mM
N-(2-[[3-cyano-6-methyl-5-(2-methyl-1,3-thiazol-4-yl)pyridin-2-yl]sulfanyl]ethyl)-3-(trifluoromethyl)benzene-1-sulfonamide
-
-
N-(2H-1,3-benzodioxol-5-yl)-4,6-dimethyl-1H-indole-2-carboxamide
-
-
N-(4-butyl-2-methylphenyl)-2-[(5-cyano-4-cyclohexyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]acetamide
-
-
N-ethyl-3(3-dimethylaminopropyl)carbodiimide
-
-
N-ethylmaleimide
-
-
N-[2-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]phenyl]-2,2,2-trifluoroacetamide
-
-
N-[3,5-bis(trifluoromethyl)phenyl]-2-[(5-chloro-1,3-benzoxazol-2-yl)sulfanyl]acetamide
-
-
N-[3-(4-chlorophenyl)-4-cyano-5-(methylsulfanyl)thiophen-2-yl]morpholine-4-carboxamide
-
-
N-[4-cyano-5-(methylthio)-2-thienyl]-N'-[3-(trifluoromethyl)phenyl]urea
-
-
N6-(6-aminohexyl)-2',5'-ADP
-
competitive inhibition
NADPH
-
reversible inhibition, is turned to irreversible in presence of 4 M urea
octylglucoside
-
inhibits reduction of plastoquinone
oxidized ferredoxin
-
inhibits binding of reduced ferredoxin and reduction of flavin
rubredoxin
-
SDS
-
inhibits reduction of plastoquinone almost completely at 15 mM
sorbitol
-
0.25M
Triazine dyes
-
Triton X-100
-
inhibits reduction of plastoquinone
Urea
-
1 M urea reduces activity by 20%, 2 M urea by 40%, and 3 M urea by 80%, concentrations over 5 M urea eliminate activity
Zn2+
-
80% inhibition
[Cr[CN]6]4-
-
binds to the enzyme
additional information
-