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1.18.1.6: adrenodoxin-NADP+ reductase

This is an abbreviated version!
For detailed information about adrenodoxin-NADP+ reductase, go to the full flat file.

Word Map on EC 1.18.1.6

Reaction

2 reduced adrenodoxin +

NADP+
+
H+
= 2 oxidized adrenodoxin +
NADPH

Synonyms

AdR, adrenodoxin oxidoreductase, adrenodoxin reductase, ADX reductase, AdxR, FDXR, ferredoxin reductase, FLP, FprA, NADPH adrenodoxin reductase, NADPH-adrenodoxin reductase, NADPH-dependent adrenodoxin reductase, NADPH:adrenal ferredoxin adrenodoxin reductase, NADPH:adrenal ferredoxin oxidoreductase, NADPH:adrenodoxin oxidoreductase, NADPH:adrenodoxin oxidoreductase mitochondrial, NADPH:adrenodoxin reductase, nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase, TPNH-cytochrome P-450 reductase

ECTree

     1 Oxidoreductases
         1.18 Acting on iron-sulfur proteins as donors
             1.18.1 With NAD+ or NADP+ as acceptor
                1.18.1.6 adrenodoxin-NADP+ reductase

Reference

Reference on EC 1.18.1.6 - adrenodoxin-NADP+ reductase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hanukoglu, I.; Jefcoate, C.R.
Mitochondrial cytochrome P-450sec. Mechanism of electron transport by adrenodoxin
J. Biol. Chem.
255
3057-3061
1980
Bos taurus
Manually annotated by BRENDA team
Hiwatashi, A.; Ichikawa, Y.; Maruya, N.; Yamano, T.; Aki, K.
Properties of crystalline reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase from bovine adrenocortical mitochondria. I. Physicochemical properties of holo- and apo-NADPH-adrenodoxin reductase and interaction between non-heme iron proteins and the reductase
Biochemistry
15
3082-3090
1976
Bos taurus
Manually annotated by BRENDA team
Hiwatashi, A.; Ichikawa, Y.; Yamano, T.
Crystallization and properties of reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase of pig adrenocortical mitochondria
FEBS Lett.
82
201-205
1977
Sus scrofa
Manually annotated by BRENDA team
Hanukoglu, I.; Gutfinger, T.; Haniu, M.; Shively, J.E.
Isolation of a cDNA for adrenodoxin reductase (ferredoxin-NADP+ reductase). Implications for mitochondrial cytochrome P-450 systems
Eur. J. Biochem.
169
449-455
1987
Bos taurus
Manually annotated by BRENDA team
Hiwatashi, A.; Ichikawa, Y.; Yamano, T.; Maruya, N.
Properties of crystalline reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase from bovine adrenocortical mitochondria. II. Essential histidyl and cysteinyl residues at the NADPH binding site of NADPH-adrenodoxin reductase
Biochemistry
15
3091-3097
1976
Bos taurus
Manually annotated by BRENDA team
Omura, T.; Sanders, E.; Estabrook, R.W.; Cooper, D.Y.; Rosenthal, O.
Isolation from adrenal cortex of a nonheme iron protein and a flavoprotein functional as a reduced triphosphopyridine nucleotide-cytochrome P-450 reductase
Arch. Biochem. Biophys.
117
660-672
1966
Bos taurus
-
Manually annotated by BRENDA team
Warburton, R.J.; Seybert D.W.
Structural and functional characterization of bovine adrenodoxin reductase by limited proteolysis
Biochim. Biophys. Acta
1246
39-46
1995
Bos taurus
Manually annotated by BRENDA team
Ziegler, G.A.; Schulz, G.E.
Crystal structures of adrenodoxin reductase in complex with NADP+ and NADPH suggesting a mechanism for the electron transfer of an enzyme family
Biochemistry
39
10986-10995
2000
Bos taurus (P08165)
Manually annotated by BRENDA team
Kuban R.J.; Marg, A.; Resch, M.; Ruckpaul, K.
Crystallization of bovine adrenodoxin reductase in a new unit cell and its crystallographic characterization
J. Mol. Biol.
234
245-248
1993
Bos taurus
Manually annotated by BRENDA team
McLean, K.J.; Scrutton, N.S.; Munro, A.W.
Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA
Biochem. J.
372
317-327
2003
Mycobacterium tuberculosis (P9WIQ3), Mycobacterium tuberculosis
Manually annotated by BRENDA team
Tuckey, R.C.; Headlam, M.J.
Placental cytochrome P450scc (CYP11A1): comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase
J. Steroid Biochem. Mol. Biol.
81
153-158
2002
Homo sapiens
Manually annotated by BRENDA team
Ewen, K.M.; Schiffler, B.; Uhlmann-Schiffler, H.; Bernhardt, R.; Hannemann, F.
The endogenous adrenodoxin reductase-like flavoprotein arh1 supports heterologous cytochrome P450-dependent substrate conversions in Schizosaccharomyces pombe
FEMS Yeast Res.
8
432-441
2008
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Liao, W.; Heo, G.; Dodder, N.; Pikuleva, I.; Turko, I.
Optimizing the conditions of a multiple reaction monitoring assay for membrane proteins: Quantification of cytochrome P450 11A1 and adrenodoxin reductase in bovine adrenal cortex and retina
Anal. Chem.
82
5760-5767
2010
Bos taurus
Manually annotated by BRENDA team
Kobayashi, K.; Miura, S.; Miki, M.; Ichikawa, Y.; Tagawa, S.
Interaction of NADPH-adrenodoxin reductase with NADP+ as studied by pulse radiolysis
Biochemistry
34
12932-12936
1995
Bos taurus
Manually annotated by BRENDA team
Cao, P.R.; Buelow, H.; Dumas, B.; Bernhardt, R.
Construction and characterization of a catalytic fusion protein system: P-45011beta-adrenodoxin reductase-adrenodoxin
Biochim. Biophys. Acta
1476
253-264
2000
Bos taurus
Manually annotated by BRENDA team
Sagara, Y.; Wada, A.; Takata, Y.; Waterman, M.; Sekimizu, K.; Horiuchi, T.
Direct expression of adrenodoxin reductase in Escherichia coli and the functional characterization
Biol. Pharm. Bull.
16
627-630
1993
Bos taurus
Manually annotated by BRENDA team
Hanukoglu, I.; Hanukoglu, Z.
Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum. Implications for membrane organization and gene regulation
Eur. J. Biochem.
157
27-31
1986
Bos taurus
Manually annotated by BRENDA team
Hanukoglu, I.; Gutfinger, T.
cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases
Eur. J. Biochem.
180
479-484
1989
Bos taurus
Manually annotated by BRENDA team
Mueller, E.C.; Lapko, A.; Otto, A.; Mueller, J.J.; Ruckpaul, K.; Heinemann, U.
Covalently crosslinked complexes of bovine adrenodoxin with adrenodoxin reductase and cytochrome P450scc. Mass spectrometry and Edman degradation of complexes of the steroidogenic hydroxylase system
Eur. J. Biochem.
268
1837-1843
2001
Bos taurus
Manually annotated by BRENDA team
de Rosa, M.; Pennati, A.; Pandini, V.; Monzani, E.; Zanetti, G.; Aliverti, A.
Enzymatic oxidation of NADP+ to its 4-oxo derivative is a side-reaction displayed only by the adrenodoxin reductase type of ferredoxin-NADP+ reductases
FEBS J.
274
3998-4007
2007
Bos taurus
Manually annotated by BRENDA team
Cenas, N.; Marcinkeviciene, J.; Kulys, J.; Usanov, S.
A negative cooperativity between NADPH and adrenodoxin on binding to NADPH:adrenodoxin reductase
FEBS Lett.
259
338-340
1990
Bos taurus
Manually annotated by BRENDA team
Sugiyama, T.; Yamano, T.
Purification and crystallization of NADPH adrenodoxin reductase from bovine adrenocortical mitochondria
FEBS Lett.
52
145-148
1975
Bos taurus
Manually annotated by BRENDA team
Hara, T.; Kimura, T.
Active complex between adrenodoxin reductase and adrenodoxin in the cytochrome P-450scc reduction reaction
J. Biochem.
105
601-605
1989
Bos taurus
Manually annotated by BRENDA team
Fujii, S.; Nonaka, Y.; Okamoto, M.; Miura, R.
On the ligand-protein and ligand-flavin interactions in NADPH-adrenodoxin reductase as studied by
J. Biochem.
109
144-149
1991
Bos taurus
Manually annotated by BRENDA team
Sakamoto, H.; Ohta, M.; Miura, R.; Sugiyama, T.; Yamano, T.; Miyake, Y.
Studies on the reaction mechanism of NADPH-adrenodoxin reductase with NADPH
J. Biochem.
92
1941-1950
1982
Bos taurus
Manually annotated by BRENDA team
Hiwatashi, A.; Ichikawa, Y.
Purification and properties of the tightly bound reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase of bovine adrenocortical mitochondria
J. Biochem.
92
335-342
1982
Bos taurus
Manually annotated by BRENDA team
Chu, J.; Kimura, T.
Studies on adrenal steroid hydroxylases. Molecular and catalytic properties of adrenodoxin reductase (a flavoprotein)
J. Biol. Chem.
248
2089-2094
1973
Bos taurus
Manually annotated by BRENDA team
Driscoll, W.; Omdahl, J.
Kidney and adrenal mitochondria contain two forms of NADPH-adrenodoxin reductase-dependent iron-sulfur proteins. Isolation of the two porcine renal ferredoxins
J. Biol. Chem.
261
4122-4125
1986
Bos taurus
Manually annotated by BRENDA team
Miura, S.; Tomita, S.; Ichikawa, Y.
Modification of histidine 56 in adrenodoxin with diethyl pyrocarbonate inhibited the interaction with cytochrome P-450scc and adrenodoxin reductase
J. Biol. Chem.
266
19212-19216
1991
Bos taurus
Manually annotated by BRENDA team
Ziegler, G.A.; Vonrhein, C.; Hanukoglu, I.; Schulz, G.E.
The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis
J. Mol. Biol.
289
981-990
1999
Bos taurus (P08165)
Manually annotated by BRENDA team
Salamanca-Pinzon, S.; Guengerich, F.
A tricistronic human adrenodoxin reductase-adrenodoxin-cytochrome P450 27A1 vector system for substrate hydroxylation in Escherichia coli
Protein Expr. Purif.
79
231-236
2011
Homo sapiens
Manually annotated by BRENDA team
Imamichi, Y.; Mizutani, T.; Ju, Y.; Matsumura, T.; Kawabe, S.; Kanno, M.; Yazawa, T.; Miyamoto, K.
Transcriptional regulation of human ferredoxin reductase through an intronic enhancer in steroidogenic cells
Biochim. Biophys. Acta
1839
33-42
2014
Homo sapiens
Manually annotated by BRENDA team
Linares, C.I.; Ferrin, G.; Aguilar-Melero, P.; Gonzalez-Rubio, S.; Rodriguez-Peralvarez, M.; Sanchez-Arago, M.; Chicano-Galvez, E.; Cuezva, J.M.; Montero-Alvarez, J.L.; Muntane, J.; de la Mata, M.
Sensitivity to anti-Fas is independent of increased cathepsin D activity and adrenodoxin reductase expression occurring in NOS-3 overexpressing HepG2 cells
Biochim. Biophys. Acta
1853
1182-1194
2015
Homo sapiens
Manually annotated by BRENDA team
Khatri, Y.; Carius, Y.; Ringle, M.; Lancaster, C.R.; Bernhardt, R.
Structural characterization of CYP260A1 from Sorangium cellulosum to investigate the 1alpha-hydroxylation of a mineralocorticoid
FEBS Lett.
590
4638-4648
2016
Bos taurus
Manually annotated by BRENDA team
Khatri, Y.; Schifrin, A.; Bernhardt, R.
Investigating the effect of available redox protein ratios for the conversion of a steroid by a myxobacterial CYP260A1
FEBS Lett.
591
1126-1140
2017
Bos taurus
Manually annotated by BRENDA team
Abdulmughni, A.; Jozwik, I.K.; Putkaradze, N.; Brill, E.; Zapp, J.; Thunnissen, A.W.; Hannemann, F.; Bernhardt, R.
Characterization of cytochrome P450 CYP109E1 from Bacillus megaterium as a novel vitamin D3 hydroxylase
J. Biotechnol.
243
38-47
2017
Bos taurus
Manually annotated by BRENDA team
Hanukoglu, I.
Conservation of the enzyme-coenzyme interfaces in FAD and NADP binding adrenodoxin reductase - a ubiquitous enzyme
J. Mol. Evol.
85
205-218
2017
Bos taurus (P08165)
Manually annotated by BRENDA team
Ershov, P.; Mezentsev, Y.; Gilep, A.; Usanov, S.; Buneeva, O.; Medvedev, A.; Ivanov, A.
Isatin-induced increase in the affinity of human ferrochelatase and adrenodoxin reductase interaction
Protein Sci.
26
2458-2462
2017
Homo sapiens
Manually annotated by BRENDA team
Khalil, M.; Bernhardt, R.; Hellwig, P.
Raman and infrared spectroscopic evidence for the structural changes of the 2Fe2S cluster and its environment during the interaction of adrenodoxin and adrenodoxin reductase
Spectrochim. Acta A. Mol. Biomol. Spectrosc.
183
298-305
2017
Bos taurus
Manually annotated by BRENDA team