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1.2.1.10: acetaldehyde dehydrogenase (acetylating)

This is an abbreviated version!
For detailed information about acetaldehyde dehydrogenase (acetylating), go to the full flat file.

Word Map on EC 1.2.1.10

Reaction

acetaldehyde
+
CoA
 +
NAD+
=
acetyl-CoA
 +
NADH
 +
H+

Synonyms

4-hydroxy-2-ketovalerate aldolase/acylating acetaldehyde dehydrogenase, ACDH, acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating], acetaldehyde-alcohol dehydrogenase, acetyl-CoA reductase, acylating acetaldehyde dehydrogenase, AdhE, ADHES77, aldehyde dehydrogenase, aldehyde dehydrogenase (acylating), aldehyde/alcohol dehydrogenase, ALDH, BAD, bi-functional alcohol/aldehyde dehydrogenase, bifunctional acetaldehyde-alcohol dehydrogenase, BphJ, CoA-acylating aldehyde dehydrogenase, CoA-dependent aldehyde dehydrogenase, coenzyme A linked aldehyde dehydrogenase, coenzyme A-acylating aldehyde dehydrogenase, DmpF, DmpFG, MhpF, More, NAD+/CoA-dependent aldehyde dehydrogenase, nonphosphorylating acylating aldehyde dehydrogenase, PduP, Teth514_0627, Teth514_1942, Tsac_0416, TTHB247

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.10 acetaldehyde dehydrogenase (acetylating)

Specific Activity

Specific Activity on EC 1.2.1.10 - acetaldehyde dehydrogenase (acetylating)

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.04
gene AdhE deletion mutant, cosubstrate NADH, pH 7.0, 55°C
0.05
wild-type, cosubstrate NADPH, pH 7.0, 55°C
0.1
gene AdhE deletion mutant, cosubstrate NADPH, pH 7.0, 55°C
0.11
-
cofactor NADP+, pH 7.0, 30°C
0.16
wild-type, cosubstrate NADPH, pH 7.0, 55°C
0.47
-
cofactor NADP+, presence of CoA, pH 7.0, 30°C
1.38
-
cofactor NAD+, pH 7.0, 30°C
1.6
crude extracts from expression in Escherichia coli DH5alpha, one unit is defined as the amount of enzyme activity that catalysed the transformation of 1 micromol NADH per min
18.8
-
cleavage of thioester, cofactor NADH, pH 8.0, 60°C
2.18
wild-type, cosubstrate NADH, pH 7.0, 55°C
2.8
-
cleavage of thioester, cofactor NADPH, pH 8.0, 60°C
29.9
-
condensation of thioester, cofactor NAD+, pH 10.0, 60°C
3.7
-
condensation of thioester, cofactor NADP+, pH 10.0, 60°C
4.88
-
undialyzed, anaerobically purified
60.6
recombinant enzyme
8.75
-
bifunctional fusion protein of aldehyde and alcohol dehydrogenase
9.62
-
dialyzed, incubated with dithiothreitol and CoA