1.2.1.16: succinate-semialdehyde dehydrogenase [NAD(P)+]
This is an abbreviated version!
For detailed information about succinate-semialdehyde dehydrogenase [NAD(P)+], go to the full flat file.
Word Map on EC 1.2.1.16
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1.2.1.16
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gamma-aminobutyric
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seizure
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neurotransmitter
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transaminase
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gamma-hydroxybutyric
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4-hydroxybutyric
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aldh5a1
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epilepsy
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shunt
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aciduria
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subdural
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hematoma
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gabaergic
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ssadhd
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hypotonia
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gaba-transaminase
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gaba-t
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4-aminobutyrate
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vigabatrin
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neurometabolic
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globus
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tonic-clonic
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pallidi
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2.6.1.19
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hyperintensities
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evacuation
- 1.2.1.16
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gamma-aminobutyric
- seizure
-
neurotransmitter
- transaminase
-
gamma-hydroxybutyric
-
4-hydroxybutyric
- aldh5a1
- epilepsy
-
shunt
- aciduria
-
subdural
- hematoma
-
gabaergic
-
ssadhd
- hypotonia
- gaba-transaminase
- gaba-t
- 4-aminobutyrate
- vigabatrin
-
neurometabolic
-
globus
-
tonic-clonic
-
pallidi
-
2.6.1.19
-
hyperintensities
-
evacuation
Reaction
Synonyms
3-sulfopropanal dehydrogenase, ALDH, BADH, BsSSADH, cce4228, cce4228 protein, dehydrogenase, succinate semialdehyde (nicotinamide adenine dinucleotide (phosphate)), gabD, GabD dehydrogenase, GabD1, gapN-2, More, NAD(P)+-coupled 3-sulfopropanal dehydrogenase, NAD(P)+-dependent benzaldehyde dehydrogenase, NAD(P)+-dependent succinate semialdehyde dehydrogenase, NAD(P)+-dependent succinic semialdehyde dehydrogenase, NAD(P)-dependent benzaldehyde dehydrogenase, NAD+/NADP+-dependent benzaldehyde dehydrogenase, NAD+/NADP+-dependent SSADH, SpSSADH, SSA dehydrogenase, SSADH, SSADH-II, SSADHase, SSDH, SSO1842, ST0064, succinate semialdehyde dehydrogenase, succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate)), succinate-semialdehyde dehydrogenase, succinate-semialdehyde dehydrogenase (NAD(P)), succinate-semialdehyde dehydrogenase (NAD(P)+), succinic semialdehyde dehydrogenase, succinic semialdehyde:NAD(P)+ oxidoreductase, sulfopropanal dehydrogenase, YneI
ECTree
1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]Advanced search results
results (
results (Specific Activity
Specific Activity on EC 1.2.1.16 - succinate-semialdehyde dehydrogenase [NAD(P)+]
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SPECIFIC ACTIVITY [µmol/min/mg] 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
0.0017
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wild type, value below, NH4+ used as N-source or uga2 mutant unable to grow on 4-aminobutyric acid, glutamate and 4-aminobutyric acid used as N-source
0.0033
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uga3 mutant unable to grow on 4-aminobutyric acid, glutamate and 4-aminobutyric acid used as N-source
0.021
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wild type, succinate used as C-source, gamma-aminobutyrate and NH3 used as N-source
0.023
0.026
0.03
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bis(3-aminopropyl)-amine and glucose, glucose and NH3 or ribose and NH3 used as C-source and N-source
0.034
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wild type, 4-hydroxyphenylacetate used as C-source and NH3 used as N-source
0.06
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4-hydroxyphenylacetic acid and glucose used as carbon source, NH3 used as N-source
0.075
0.078
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glycerol used as carbon source, 4-aminobutyric acid used as N-source
0.08
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4-hydroxyphenylacetic acid used as carbon source, NH3 used as N-source
0.085
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4-aminobutyric acid used as carbon source, NH3 used as N-source
0.091
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4-hydroxyphenylacetic acid, glucose and cAMP used as carbon source, NH3 used as N-source
0.105
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wild type, succinate used as C-source and gamma-aminobutyrate used as N-source
0.125
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uga1 mutant unable to grow on 4-aminobutyric acid, glutamate and 4-aminobutyric acid used as N-source
0.13
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4-hydroxyphenylacetic acid and cAMP used as carbon source, NH3 used as N-source
0.319
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mutant, gamma-aminobutyrate used as C-source and NH3 used as N-source
0.351
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mutant, succinate used as C-source and gamma-aminobutyrate used as N-source
0.38
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wild type, glutamate and 4-aminobutyric acid used as N-source
0.395
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mutant, glucose used as C-source and gamma-aminobutyrate used as N-source
8.5
additional information
additional information
specific activity of 0.3 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with ammonium as the sole nitrogen source, substrate is sulfopropanal and NADP+
additional information
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specific activity of 0.3 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with ammonium as the sole nitrogen source, substrate is sulfopropanal and NADP+
additional information
specific activity of 0.5 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with ammonium as the sole nitrogen source, substrate is succinale semialdehyde and NAD+
additional information
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specific activity of 0.5 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with ammonium as the sole nitrogen source, substrate is succinale semialdehyde and NAD+
additional information
specific activity of 0.5 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with ammonium as the sole nitrogen source, substrate is succinale semialdehyde and NADP+
additional information
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specific activity of 0.5 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with ammonium as the sole nitrogen source, substrate is succinale semialdehyde and NADP+
additional information
specific activity of 0.6 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with ammonium as the sole nitrogen source, substrate is sulfopropanal and NAD+
additional information
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specific activity of 0.6 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with ammonium as the sole nitrogen source, substrate is sulfopropanal and NAD+
additional information
specific activity of 0.7 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with 4-aminobutyrate as the sole nitrogen source, substrate is succinale semialdehyde and NADP+
additional information
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specific activity of 0.7 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with 4-aminobutyrate as the sole nitrogen source, substrate is succinale semialdehyde and NADP+
additional information
specific activity of 10 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with homotaurine as the sole nitrogen source, substrate is sulfopropanal and NADP+
additional information
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specific activity of 10 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with homotaurine as the sole nitrogen source, substrate is sulfopropanal and NADP+
additional information
specific activity of 2.5 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with 4-aminobutyrate as the sole nitrogen source, substrate is sulfopropanal and NADP+
additional information
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specific activity of 2.5 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with 4-aminobutyrate as the sole nitrogen source, substrate is sulfopropanal and NADP+
additional information
specific activity of 3 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with 4-aminobutyrate as the sole nitrogen source, substrate is sulfopropanal and NAD+
additional information
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specific activity of 3 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with 4-aminobutyrate as the sole nitrogen source, substrate is sulfopropanal and NAD+
additional information
specific activity of 5 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with homotaurine as the sole nitrogen source, substrate is sulfopropanal and NAD+
additional information
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specific activity of 5 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with homotaurine as the sole nitrogen source, substrate is sulfopropanal and NAD+
additional information
specific activity of 5.0 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with 4-aminobutyrate as the sole nitrogen source, substrate is succinale semialdehyde and NAD+
additional information
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specific activity of 5.0 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with 4-aminobutyrate as the sole nitrogen source, substrate is succinale semialdehyde and NAD+
additional information
specific activity of 7.0 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with homotaurine as the sole nitrogen source, substrate is succinale semialdehyde and NADP+
additional information
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specific activity of 7.0 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with homotaurine as the sole nitrogen source, substrate is succinale semialdehyde and NADP+
additional information
specific activity of 7.3 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with homotaurine as the sole nitrogen source, substrate is succinale semialdehyde and NAD+
additional information
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specific activity of 7.3 mkat/kg protein is detected in crude cell extracts of Cupriavidus necator grown with homotaurine as the sole nitrogen source, substrate is succinale semialdehyde and NAD+
additional information
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Good activity with several alternate substrates including the aromatic substrates, 4-chloro- and 3-hydroxy-benzaldehyde, as well as cyclohexanal. BADH is most active with medium chain aliphatic substrates such as pentanal and hexanal.The level of activity with aliphatic substrates drops off rapidly as the chain length decreased with very little activity (<0.1%) being observed with acetaldehyde.
