1.2.1.18: malonate-semialdehyde dehydrogenase (acetylating)

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For detailed information about malonate-semialdehyde dehydrogenase (acetylating), go to the full flat file.

Reaction

Synonyms

Aldh6a1, dehydrogenase, malonate semialdehyde, FG99_15390, KES23460, malonate semialdehyde oxidative decarboxylase, malonate-semialdehyde dehydrogenase, malonate-semialdehyde dehydrogenase (NADP+) (acylating), malonate-semialdehyde: nicotinamide adenine dinucleotide oxidoreductase, malonic semialdehyde oxidative decarboxylase, methylmalonate-semialdehyde dehydrogenase, NAD-dependent malonate-semialdehyde dehydrogenase

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.18 malonate-semialdehyde dehydrogenase (acetylating)

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Results	in table
1	Activating Compound
1427	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
14	Cofactor
1	Crystallization (Commentary)
35	Disease/ Diagnostics
2	General Stability
4	Inhibitors
7	KM Value [mM]
4	Localization
2	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
13	Organism
11	Pathway
7	pH Optimum
2	pH Range
5	Purification (Commentary)
1	Reaction
3	Reaction Type
11	Reference
18	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
17	Substrates and Products (Substrate)
3	Subunits
17	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 1.2.1.18 - malonate-semialdehyde dehydrogenase (acetylating)

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2-methyl-3-oxopropanoate + CoA + NAD+

propanoyl-CoA + CO2 + NADH

Rattus norvegicus

-

both stereoisomers

288055

-

288055

?

3-oxopropanoate + CoA + NAD+

acetyl-CoA + CO2 + NADH

10 entries

3-oxopropanoate + CoA + NADP+

acetyl-CoA + CO2 + NADPH

Pseudomonas sp.

-

-

288058

-

288058

?

acetaldehyde + NAD+ + H2O

acetate + NADH + H+

Mus musculus

Q9EQ20

-

690142

-

-

?

malonyl-CoA + NADPH

malonate-semialdehyde + CoA + NADP+

2 entries

additional information

?

-

2 entries

3-oxopropanoate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Pseudomonas aeruginosa

-

-

288056

-

288056

?

3-oxopropanoate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Pseudomonas aeruginosa

-

enzyme is involved in catabolism of beta-alanine

288056

-

288056

?

3-oxopropanoate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Pseudomonas fluorescens

-

-

288057

-

288057

?

3-oxopropanoate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Pseudomonas fluorescens

-

-

288060

-

-

?

3-oxopropanoate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Pseudomonas fluorescens

-

-

288059

-

288059

ir

3-oxopropanoate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Pseudomonas fluorescens

-

inducible enzyme, beta-alanine seems to be the real inducer

288057

-

288057

?

3-oxopropanoate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Pseudomonas sp.

-

-

741539

-

-

?

3-oxopropanoate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Pseudomonas sp.

-

-

288058

-

288058

ir

3-oxopropanoate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Pseudomonas sp. AAC

-

-

741539

-

-

?

3-oxopropanoate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Rattus norvegicus

-

-

288055

-

288055

?

malonyl-CoA + NADPH

malonate-semialdehyde + CoA + NADP+

Chloroflexus aurantiacus

-

-

288061

-

288061

?

malonyl-CoA + NADPH

malonate-semialdehyde + CoA + NADP+

Chloroflexus aurantiacus

-

enzyme is involved in the autotrophic CO2 fixation pathway, the 3-hydroxypropionate cycle

288061

-

288061

?

additional information

?

-

Pseudomonas sp.

-

the malonate-semialdehyde dehydrogenase is selective towards malonate semialdehyde and generates acetyl-CoA in an NAD-dependent and CoA-dependent reaction, although a slower CoA-independent reaction generating acetate is also observed

741539

-

-

?

additional information

?

-

Pseudomonas sp. AAC

-

the malonate-semialdehyde dehydrogenase is selective towards malonate semialdehyde and generates acetyl-CoA in an NAD-dependent and CoA-dependent reaction, although a slower CoA-independent reaction generating acetate is also observed

741539

-

-

?