1.2.1.24: succinate-semialdehyde dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about succinate-semialdehyde dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.2.1.24

1.2.1.24

aldhs

gamma-hydroxybutyric

ssadhd

4-hydroxybutyric

propionaldehyde

trans-4-hydroxy-2-nonenal

aldh4a1

akr7a2

ssadh-deficient

medicine

Reaction

Synonyms

aldehyde dehydrogenase 5a1, ALDH5A, ALDH5A1, alphaKGSA dehydrogenase, dehydrogenase, succinate semialdehyde, NAD(+)-dependent succinic semialdehyde dehydrogenase, SSADH, SSADH-I, SSADH/ALDH5A1, SSALDH, SSO1629, succinate semialdehyde dehydrogenase, succinate semialdehyde:NAD+ oxidoreductase, succinic semialdehyde dehydrogenase, succinyl semialdehyde dehydrogenase, YneI dehydrogenase

ECTree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)

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Results	in table
11	Activating Compound
2490	AA Sequence
8	Application
1	CAS Registry Number
19	Cloned(Commentary)
76	Cofactor
2	Crystallization (Commentary)
122	Disease/ Diagnostics
2	Expression
15	General Information
3	General Stability
6	IC50 Value
103	Inhibitors
3	kcat/KM [mM/s]
10	Ki Value [mM]
119	KM Value [mM]
15	Localization
1	Metals/Ions
42	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
124	Organism
2	Oxidation Stability
11	Pathway
9	PDB ID
20	pH Optimum
9	pH Range
5	pH Stability
1	pI Value
67	Protein Variants
20	Purification (Commentary)
5	Reaction
3	Reaction Type
82	Reference
63	Source Tissue
12	Specific Activity [micromol/min/mg]
8	Storage Stability
197	Substrates and Products (Substrate)
24	Subunits
110	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
6	Temperature Stability [°C]
7	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.2.1.24 - succinate-semialdehyde dehydrogenase (NAD+)

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4-hydroxy-trans-2-nonenal + NAD+

Rattus norvegicus

elevated levels of 4-hydroxy-trans-2-nonenal are implicated in the pathogenesis of numerous neurodegenerative disorders. Succinate-semialdehyde dehydrogenase is the predominant oxidizing enzyme for 4-hydroxy-trans-2-nonenal but only contributes a portion of the total oxidizing activity in liver mitochondria

656587

4-hydroxy-trans-2-nonenal + NAD+ + H2O

4-hydroxy-trans-2-nonenoate + NADH + H+

2 entries

succinate semialdehyde + NAD+ + H2O

succinate + NADH

9 entries

succinate semialdehyde + NAD+ + H2O

succinate + NADH + 2 H+

5 entries

succinate semialdehyde + NAD+ + H2O

succinate + NADH + H+

8 entries

additional information

2 entries