1.2.1.24: succinate-semialdehyde dehydrogenase (NAD+)
This is an abbreviated version!
For detailed information about succinate-semialdehyde dehydrogenase (NAD+), go to the full flat file.
Word Map on EC 1.2.1.24
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1.2.1.24
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aldhs
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gamma-hydroxybutyric
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ssadhd
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4-hydroxybutyric
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propionaldehyde
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trans-4-hydroxy-2-nonenal
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aldh4a1
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akr7a2
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ssadh-deficient
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medicine
- 1.2.1.24
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aldhs
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gamma-hydroxybutyric
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ssadhd
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4-hydroxybutyric
- propionaldehyde
- trans-4-hydroxy-2-nonenal
- aldh4a1
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akr7a2
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ssadh-deficient
- medicine
Reaction
Synonyms
aldehyde dehydrogenase 5a1, ALDH5A, ALDH5A1, alphaKGSA dehydrogenase, dehydrogenase, succinate semialdehyde, NAD(+)-dependent succinic semialdehyde dehydrogenase, SSADH, SSADH-I, SSADH/ALDH5A1, SSALDH, SSO1629, succinate semialdehyde dehydrogenase, succinate semialdehyde:NAD+ oxidoreductase, succinic semialdehyde dehydrogenase, succinyl semialdehyde dehydrogenase, YneI dehydrogenase
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Natural Substrates Products
Natural Substrates Products on EC 1.2.1.24 - succinate-semialdehyde dehydrogenase (NAD+)
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REACTION DIAGRAM
4-hydroxy-trans-2-nonenal + NAD+
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elevated levels of 4-hydroxy-trans-2-nonenal are implicated in the pathogenesis of numerous neurodegenerative disorders. Succinate-semialdehyde dehydrogenase is the predominant oxidizing enzyme for 4-hydroxy-trans-2-nonenal but only contributes a portion of the total oxidizing activity in liver mitochondria
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4-hydroxy-trans-2-nonenoate + NADH + H+
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4-hydroxy-trans-2-nonenal + NAD+ + H2O
4-hydroxy-trans-2-nonenoate + NADH + H+
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succinate + NADH
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enzyme is induced by growth on gamma-aminobutyrate
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succinate semialdehyde + NAD+ + H2O
succinate + NADH
last enzyme in catabolism of 4-aminobutyric acid. Human SSADH deficiency results in 4-hydroxybutyric aciduria, an autosomal recessive disorder due to an accumulation of 4-aminobutyric acid and 4-hydroxybutyric acid in the CNS
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ir
succinate semialdehyde + NAD+ + H2O
succinate + NADH
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enzyme of agmatine degradation
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succinate semialdehyde + NAD+ + H2O
succinate + NADH
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enzyme is induced by growth on gamma-aminobutyrate
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succinate semialdehyde + NAD+ + H2O
succinate + NADH
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enzyme is induced by succinate semialdehyde, functions in the oxidation of succinate semialdehyde during growth on both 4-hydroxyphenylacetate and 4-aminobutyrate
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succinate semialdehyde + NAD+ + H2O
succinate + NADH
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enzyme is induced by succinate semialdehyde, functions in the oxidation of succinate semialdehyde during growth on both 4-hydroxyphenylacetate and 4-aminobutyrate
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succinate semialdehyde + NAD+ + H2O
succinate + NADH
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enzyme may play an important role, not only in metabolizing succinate semialdehyde but also in oxidation of aromatic aldehydes in the soil environment
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succinate semialdehyde + NAD+ + H2O
succinate + NADH
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induced by pyridine, the enzyme is involved in the degradation of pyridine
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succinate semialdehyde + NAD+ + H2O
succinate + NADH
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enzyme is involved in the catabolism of the neurotransmitter 4-aminobutyrate
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succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
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succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
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succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
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succinate + NADH + H+
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enzyme of the gamma-aminobutyrate shunt required to restrict levels of reactive oxygen intermediates in plants
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succinate semialdehyde + NAD+ + H2O
succinate + NADH + H+
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deficiency of succinate semialdehyde dehydrogenase is a rare autosomal recessively inherited metabolic disorder that results in acumulation of 4-hydroxybutyrate. Functional analysis of 27 novel disease-causing mutations in patients with SSADH deficiency
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additional information
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ALDH5A1 plays an important role as a gamma-aminobutyric acid catabolic enzyme and potentially as a detoxifying enzyme involved in aldehyde scavenging
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