1.2.1.26: 2,5-dioxovalerate dehydrogenase

This is an abbreviated version!
For detailed information about 2,5-dioxovalerate dehydrogenase, go to the full flat file.

Reaction

Synonyms

2-oxoglutarate semialdehyde dehydrogenase, AbKGSADH, aldehyde dehydrogenase, ALDH, alpha-ketoglutarate semialdehyde dehydrogenase, alpha-ketoglutarate-semialdehyde dehydrogenase, alpha-ketoglutaric semialdehyde dehydrogenase, alpha-KGSA dehydrogenase, alphaKGSA dehydrogenase, alphaKGSADH, araE, DopDH, KGSADH, KGSADH-I, KGSADH-II, KGSADH-III, More, SSO3117, ycbD protein

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.26 2,5-dioxovalerate dehydrogenase

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Results	in table
5	Activating Compound
933	AA Sequence
5	Application
1	CAS Registry Number
8	Cloned(Commentary)
16	Cofactor
1	Crystallization (Commentary)
5	General Information
3	Inhibitors
21	kcat/KM [mM/s]
56	KM Value [mM]
1	Metals/Ions
9	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
26	Organism
16	Pathway
4	PDB ID
6	pH Optimum
2	pH Range
18	Protein Variants
9	Purification (Commentary)
1	Reaction
3	Reaction Type
18	Reference
2	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
55	Substrates and Products (Substrate)
11	Subunits
49	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Stability [°C]
54	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.2.1.26 - 2,5-dioxovalerate dehydrogenase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

D-galactarate

Azospirillum brasilense

Q08IB7, Q08IC0, Q1JUP4

induces KGSADH-II

693021

D-glucarate

Azospirillum brasilense

Q08IB7, Q08IC0, Q1JUP4

induces KGSADH-II

693021

hydroxy-L-proline

Azospirillum brasilense

Q08IB7, Q08IC0, Q1JUP4

induces KGSADH-III

693021

L-arabinose

Azospirillum brasilense

Q08IB7, Q08IC0, Q1JUP4

induces KGSADH-I

693021

NADP+

Saccharolobus solfataricus

Q97UA1

the enzyme prefers NADP+ over NAD+

719837