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1.2.1.31: L-aminoadipate-semialdehyde dehydrogenase

This is an abbreviated version!
For detailed information about L-aminoadipate-semialdehyde dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.31

Reaction

(S)-2-amino-6-oxohexanoate
+
NAD(P)+
+
H2O
=
L-2-aminoadipate
+
NAD(P)H
+
H+

Synonyms

2-aminoadipate semialdehyde dehydrogenase, 2-aminoadipic 6-semialdehyde dehydrogenase, 2-aminoadipic semialdehyde dehydrogenase, AAR, AASADH, adipic 6-semialdehyde dehydrogenase, aldehyde dehydrogenase 7A1, Aldh7a1, alpha-AAR, alpha-AASA dehydrogenase, alpha-aminoadipate reductase Lys1p, alpha-aminoadipate semialdehyde dehydrogenase, alpha-aminoadipate-semialdehyde dehydrogenase, alpha-aminoadipic acid-delta-semialdehyde dehydrogenase, alpha-aminoadipic semialdehyde dehydrogenase, Alpha-AR, antiquitin, dehydrogenase, aminoadipate semialdehyde, human U26, L-alpha-aminoadipate delta-semialdehyde oxidoreductase, L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase, L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase, L-aminoadipate-semialdehyde dehydrogenase, Lys1p, Nalpha-Z-L-AASA dehydrogenase, U26

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase

Subunits

Subunits on EC 1.2.1.31 - L-aminoadipate-semialdehyde dehydrogenase

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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
2 * 54000, quantitative sedimentation analysis
monomer
-
1 * 155000, SDS-PAGE
tetramer
4 * 54000, quantitative sedimentation analysis
additional information
ALDH7A1 forms a dimer-of-dimers tetramer both in crystallo and in solution. NAD+-binding promotes assembly of the ALDH7A1 tetramer and enhances ALDH7A1 tetramerization at micromolar enzyme concentrations. The apoenzyme is mainly dimeric. NAD+-bound ALDH7A1 is predominantly tetrameric. The tetramer is the active form of the enzyme. The catalytically active oligomer of ALDH7A1 is assembled on demand in response to cofactor availability. The major peaks correspond to Mr of 110 kDa and 184 kDa, which are both below the theoretical Mr of the tetramer (222 kDa), consistent with an intermediate exchange regime in which free dimer exists in solution simultaneously with a dimer-tetramer equilibrium. The minor species at 2.7S (54 kDa) likely represents a monomer (theoretical Mr of 56 kDa)