1.2.1.47: 4-trimethylammoniobutyraldehyde dehydrogenase

This is an abbreviated version!
For detailed information about 4-trimethylammoniobutyraldehyde dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.47

1.2.1.47

gamma-butyrobetaine

proliferator-activated

dioxygenase

peroxisome

l-carnitine

polyunsaturated

1.2.1.8

badhs

aldh4a1

suckling

gill

betaine

acetaldehyde

trimethyllysine

Reaction

4-Trimethylammoniobutanal

+

NAD⁺

+

H2O

=

4-Trimethylammoniobutanoate

+

NADH

+ 2 H+

Synonyms

4-N-trimethylaminobutyraldehyde dehydrogenase, 4-N-trimethylaminobutyraldehyde dehydrogenase II, 4-trimethylaminobutyraldehyde dehydrogenase, 4-trimethylammoniobutyraldehyde dehydrogenase, aldehyde dehydrogenase 9A1, Aldh9a1, carnitine biosynthesis enzyme, dehydrogenase, trimethylaminobutyraldehyde, gamma-trimethylaminobutyraldehyde dehydrogenase, TMABA dehydrogenase, TMABA-DH, TMABADH, TMABAL dehydrogenase, TMABaldehyde-DH II, TMABALDH

ECTree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.47 4-trimethylammoniobutyraldehyde dehydrogenase

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Results	in table
1	Activating Compound
30	AA Sequence
1	Application
1	CAS Registry Number
5	Cloned(Commentary)
16	Cofactor
2	Crystallization (Commentary)
9	Disease/ Diagnostics
3	Expression
6	General Information
1	General Stability
44	Inhibitors
5	Ki Value [mM]
36	KM Value [mM]
8	Localization
1	Metals/Ions
9	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
19	Organism
5	Pathway
30	PDB ID
6	pH Optimum
1	pH Range
2	pH Stability
2	pI Value
7	Purification (Commentary)
1	Reaction
4	Reaction Type
18	Reference
54	Source Tissue
16	Specific Activity [micromol/min/mg]
3	Storage Stability
69	Substrates and Products (Substrate)
11	Subunits
36	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
3	Temperature Stability [°C]

KM Value

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KM Value on EC 1.2.1.47 - 4-trimethylammoniobutyraldehyde dehydrogenase

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0.026

2-hexenal

pH 7.5, temperature not specified in the publication

0.011

3,4-dihydroxyphenylacetaldehyde

pH 7.5, temperature not specified in the publication

0.056

3-aminopropionaldehyde

pH 7.5, temperature not specified in the publication

0.021

4-(dimethylamino)butyraldehyde

pH 7.5, temperature not specified in the publication

-

0.006

4-(trimethylamino)butyraldehyde

pH 7.5, temperature not specified in the publication

-

0.024 - 0.067

4-Aminobutyraldehyde

show

0.051 - 0.62

4-dimethylaminobutyraldehyde

show

0.021

4-guanidinobutyraldehyde

pH 7.5, temperature not specified in the publication

0.0074 - 0.31

4-N-trimethylaminobutyraldehyde

show

0.0014 - 0.00417

4-trimethylaminobutyraldehyde

show

0.017 - 0.102

acetaldehyde

show

0.123

Betaine aldehyde

Rattus norvegicus

-

0.013 - 0.216

Butyraldehyde

show

0.007

Heptanal

Rattus norvegicus

-

0.0088

hexadecanal

Rattus norvegicus

-

0.009 - 0.05

hexanal

show

0.053

N,N,N-trimethyl-3-aminopropionaldehyde

pH 7.5, temperature not specified in the publication

0.021

N,N-dimethyl-3-aminopropionaldehyde

pH 7.5, temperature not specified in the publication

-

0.028 - 1.16

NAD+

show

1.63

NADP+

Rattus norvegicus

-

0.006

octanal

Rattus norvegicus

-

0.01

pentanal

Rattus norvegicus

-

0.016

propionaldehyde

Rattus norvegicus

-

0.035

Valeraldehyde

pH 7.5, temperature not specified in the publication

additional information

additional information

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Release 2023.1 (January 2023)