1.2.1.49: 2-oxoaldehyde dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about 2-oxoaldehyde dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

2-ketoaldehyde dehydrogenase, alpha-ketoaldehyde dehydrogenase, methylglyoxal dehydrogenase, NADP-dependent alpha-ketoaldehyde dehydrogenase, NADP-linked alpha-ketoaldehyde dehydrogenase

ECTree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.49 2-oxoaldehyde dehydrogenase (NADP+)

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Results	in table
14	Activating Compound
2	CAS Registry Number
1	Cloned(Commentary)
17	Cofactor
11	Inhibitors
19	KM Value [mM]
4	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
11	Organism
3	Pathway
4	pH Optimum
6	pH Range
1	pH Stability
7	Purification (Commentary)
1	Reaction
3	Reaction Type
11	Reference
13	Source Tissue
6	Specific Activity [micromol/min/mg]
3	Storage Stability
28	Substrates and Products (Substrate)
2	Subunits
5	Synonyms
1	Systematic Name

Activating Compound

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Activating Compound on EC 1.2.1.49 - 2-oxoaldehyde dehydrogenase (NADP+)

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2-amino-2-methylpropan-1-ol

Ovis aries

activation of aldehyde oxidation

288143

2-amino-2-methylpropane-1,3-diol

Ovis aries

activation of aldehyde oxidation

288143

2-Aminobutan-1-ol

Ovis aries

activation of aldehyde oxidation

288143

2-aminopropane

Ovis aries

activation of aldehyde oxidation

288143

2-aminopropane-1,3-diol

Ovis aries

activation of aldehyde oxidation

288143

Amines

Homo sapiens

several amines stimulate activity

655211

D,L-2-amino-1-propanol

Rattus norvegicus

activation of aldehyde oxidation

288259

DL-2-amino-1-propanol

Homo sapiens

required, best activator of the reaction

655211

L-2-Aminopropan-1-ol

2 entries

L-serine methyl ester

Rattus norvegicus

activation of aldehyde oxidation

288256, 288259

Tris

Ovis aries

activation of aldehyde oxidation

288143