Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.2.1.5: aldehyde dehydrogenase [NAD(P)+]

This is an abbreviated version!
For detailed information about aldehyde dehydrogenase [NAD(P)+], go to the full flat file.

Word Map on EC 1.2.1.5

Reaction

an aldehyde
+
NAD(P)+
 +
H2O
=
a carboxylate
 +
NAD(P)H
 +
H+

Synonyms

acetaldehyde dehydrogenase, ALD4, aldehyde dehydrogenase, aldehyde dehydrogenase 1A3, aldehyde dehydrogenase 2, aldehyde dehydrogenase 3A1, aldehyde: NAD(P)+ oxidoreductase, ALDH, ALDH1, ALDH13, ALDH17, ALDH1a, ALDH1A1, Aldh1a3, ALDH1b, ALDH2, ALDH2a, ALDH2b, ALDH3, ALDH3A1, Aldh3b1, ALDH3F1, ALDH3H1, ALDH3I1, ALDH7B7, ALDH9, ALDHC, ALDHIII, BcALDH, BCP54, chromosomally encoded box pathway ALDH, class 3 aldehyde dehydrogenase, Corneal 15.8 kDa protein, Corneal protein 54, dehydrogenase, aldehyde (nicotinamide adenine dinucleotide (phosphate)), HTC-ALDH, K-ACDH, MI dehydrogenase, More, myo-inositol dehydrogenase, NAD(P)(+)-dependent aldehyde dehydrogenase, NAD(P)+-dependent aldehyde dehydrogenase, NAD+-dependent Ald4, nicotinprotein aldehyde dehydrogenase, OsALDH2-1, OsALDH2-2, OsALDH2-3, OsALDH2-4, OsALDH2-5, OsALDH22, OsALDH3-1, OsALDH3-2, OsALDH3-3, OsALDH3-4, OsALDH3-5, OsALDH5, OsALDH7, PEG-ALDH, PuuC, ST0064, succinic semialdehyde dehydrogenase, Transparentin, Tumor-associated aldehyde dehydrogenase, ybcD

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.5 aldehyde dehydrogenase [NAD(P)+]

Engineering

Engineering on EC 1.2.1.5 - aldehyde dehydrogenase [NAD(P)+]

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C300A
the variant shows no oxidation activity
E194S
the variant shows 15fold higher catalytic efficiency (kcat/Km) for the reduction of all-trans-retinal than the wild type enzyme
E266A
the variant shows no oxidation activity
E457V
the variant shows 7.5fold higher catalytic efficiency (kcat/Km) for the reduction of all-trans-retinal than the wild type enzyme
C300A
-
the variant shows no oxidation activity
-
E194S
-
the variant shows 15fold higher catalytic efficiency (kcat/Km) for the reduction of all-trans-retinal than the wild type enzyme
-
E266A
-
the variant shows no oxidation activity
-
E457V
-
the variant shows 7.5fold higher catalytic efficiency (kcat/Km) for the reduction of all-trans-retinal than the wild type enzyme
-
T186S
the mutant has increased activity against aldehyde and decreased activity against smaller substrates like benzaldehyde compared to the native enzyme and cells transformed with the point mutant are better protected against the killing effect of cyclophosphamides
T244A
-
the mutant exhibits reduced catalytic efficiency toward substrate and coenzyme
T244G
-
the mutant exhibits reduced catalytic efficiency toward substrate and coenzyme
T244S
-
the mutant exhibits reduced catalytic efficiency toward substrate and coenzyme
T244V
-
the mutant exhibits reduced catalytic efficiency toward substrate and coenzyme
E140D
-
Km-value for NADP+ is about half that of the native enzyme, Km-value for NAD+ is about 3.1fold that of the native enzyme, Km-value for benzaldehyde is about 1.4fold that of the native enzyme, Km-value for propanal is about 1.9fold that of the native enzyme. The coenzyme preference NADP+/NAD+ is 3.2, compared to 3.4 for the native enzyme
E140N
-
Km-value for NADP+ is about 10% of that of the native enzyme, Km-value for NAD+ is about 3.2fold that of the native enzyme, Km-value for benzaldehyde is about 1.2fold that of the native enzyme, Km-value for propanal is about 2.3fold that of the native enzyme. The coenzyme preference NADP+/NAD+ is 4.2, compared to 3.4 for the native enzyme
E140Q
-
Km-value for NADP+ is about 10% of that of the native enzyme, Km-value for NAD+ is about 7.9fold that of the native enzyme, Km-value for benzaldehyde is about 1.6fold that of the native enzyme, Km-value for propanal is about 1.1fold that of the native enzyme. The coenzyme preference NADP+/NAD+ is 2.8, compared to 3.4 for the native enzyme
E140T
-
Km-value for NADP+ is about 20% of that of the native enzyme, Km-value for NAD+ is about 15.3fold that of the native enzyme, Km-value for benzaldehyde is about 60% of that of the native enzyme, Km-value for propanal is about 1.4fold that of the native enzyme. The coenzyme preference NADP+/NAD+ is 5.8, compared to 3.4 for the native enzyme
G192A
-
Km-value for NADP+ is about half that of the native enzyme, Km-value for NAD+ is about 70% of that of the native enzyme, Km-value for benzaldehyde is about 90% of that of the native enzyme, Km-value for propanal is about 45% of that of the native enzyme
K137Q
-
Km-value for NADP+ is about 2.4fold that of the native enzyme, Km-value for NAD+ is about 16fold that of the native enzyme, Km-value for benzaldehyde is about 1.2fold that of the native enzyme, Km-value for propanal is about 95% of that of the native enzyme. The coenzyme preference NADP+/NAD+ is 1.1, compared to 3.4 for the native enzyme
C325S
additional information