1.2.1.72: erythrose-4-phosphate dehydrogenase
This is an abbreviated version!
For detailed information about erythrose-4-phosphate dehydrogenase, go to the full flat file.
Reaction
Synonyms
E4P dehydrogenase, E4PD, E4PDH, epd, Epd dehydrogenase, erythrose 4-phosphate dehydrogenase, gap2, GapB, gapB-encoded dehydrogenase, GapB-encoded protein
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Natural Substrates Products on EC 1.2.1.72 - erythrose-4-phosphate dehydrogenase
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REACTION DIAGRAM
D-erythrose 4-phosphate + NAD+
4-phosphoerythronate + NADH
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the enzyme possible plays a role in the de novo biosynthesis of pyridoxal 5'-phosphate
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enzyme is involved in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12
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additional information
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epd expression is very low in Escherichia coli. In presence of glucose, the 3 epd, pgk and fba ORFs are efficiently cotranscribed from promoter epd P0. Translational limitation of the epd expression in Escherichia coli
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gapB is dispensable for glycolysis and pyridoxal biosynthesis pathway
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expression of epd in Vibrio cholera is not regulated by iron, nor is it required for virulence in an infant model
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