1.2.1.77: 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+), go to the full flat file.
Reaction
Synonyms
3,4-dehydroadipyl-CoA semialdehyde dehydrogenase, ALDH, ALDHC, BoxD, NADP+-dependent aldehyde dehydrogenase
ECTree
1.2.1.77 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+)Advanced search results
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results (Substrates Products
Substrates Products on EC 1.2.1.77 - 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3,4-didehydroadipyl-CoA semialdehyde + NAD+ + H2O
3,4-didehydroadipyl-CoA + NADH + H+
-
-
-
r
cis-3,4-dehydroadipyl-CoA semialdehyde + NADP+ + H2O
cis-3,4-dehydroadipyl-CoA + NADPH + H+
catalytic mechanism proposed in detail
-
-
?
heptaldehyde + NADP+ + H2O
heptanoate + NADPH + H+
-
-
-
?
isovaleraldehyde + NADP+ + H2O
isovalerate + NADPH + H+
-
-
-
?
additional information
?
-
the native substrate (3,4-dehydroadipyl-CoA semialdehyde) is not tested as it is commercially unavailable. The enzyme is preferentially active towards linear medium-chain to long-chain aldehydes as compared to branched-chain, short-chain or aromatic aldehydes
-
-
?
3,4-dehydroadipyl-CoA semialdehyde + NADP+ + H2O
3,4-dehydroadipyl-CoA + NADPH + H+
-
-
-
-
?
3,4-dehydroadipyl-CoA semialdehyde + NADP+ + H2O
3,4-dehydroadipyl-CoA + NADPH + H+
-
enzyme of the aerobic benzoyl-coenzyme A catabolic pathway
-
-
?
3,4-dehydroadipyl-CoA semialdehyde + NADP+ + H2O
3,4-dehydroadipyl-CoA + NADPH + H+
-
the molar ratio of mol of converted substrate per mol of NADPH formed is estimated to be 1
-
-
?
3,4-dehydroadipyl-CoA semialdehyde + NADP+ + H2O
3,4-dehydroadipyl-CoA + NADPH + H+
-
-
-
-
?
3,4-dehydroadipyl-CoA semialdehyde + NADP+ + H2O
3,4-dehydroadipyl-CoA + NADPH + H+
the enzyme is involved in the benzoate oxidation (box) pathway
-
-
?
propionaldehyde + NADP+ + H2O
propionate + NADPH + H+
-
-
-
?
propionaldehyde + NADP+ + H2O
propionate + NADPH + H+
propionaldehyde is used as the aldehydic substrate in enzyme assay because of commercial unavailability of the native substrate
-
-
?
