1.2.4.1: pyruvate dehydrogenase (acetyl-transferring)

This is an abbreviated version!
For detailed information about pyruvate dehydrogenase (acetyl-transferring), go to the full flat file.

Reaction

Synonyms

aceE, AcoA, CTHT_0006350, CTHT_0069820, dehydrogenase, pyruvate, E1 component of pyruvate dehydrogenase, E1 component of pyruvate dehydrogenase multienzyme complex, E1 component of the pyruvate dehydrogenase multienzyme complex, E1 component subunit alpha, E1 component subunit beta, E1alpha, E1ec, E1p, IAR4, MAB1, MdeB, mitochondrial pyruvate dehydrogenase, More, MtPDC, OsI_14647, OsI_31986, Pda1, PDC, PDH, PDH E1alpha, PDH subunit E1-beta, PDH-A1, PDHa, PdhA1, PDHA1a, PdhB, PDHC, PDHc E1, PDHc-E1, PdhE, PDHE1alpha, PdhH, PH2, pyruvate decarboxylase, pyruvate dehydrogenase, pyruvate dehydrogenase complex, pyruvate dehydrogenase complex E1 component, pyruvate dehydrogenase complex,, pyruvate dehydrogenase E1, pyruvate dehydrogenase E1 alpha subunit, pyruvate dehydrogenase E1 component, pyruvate dehydrogenase E1 component subunit beta, pyruvate dehydrogenase multienzyme complex, pyruvate dehydrogenase multienzyme complex E1, pyruvate dehydrogenase, E1, pyruvate:NAD oxidoreductase, pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating), pyruvic acid dehydrogenase, pyruvic dehydrogenase, thiamin diphosphate-dependent pyruvate dehydrogenase, thiamin-dependent pyruvate dehydrogenase, thiamine diphosphate-dependent 2-oxo acid decarboxylase, VEG220, Vegetative protein 220

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.4 With a disulfide as acceptor

                1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)

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Results	in table
2	Activating Compound
60141	AA Sequence
15	Application
1	CAS Registry Number
26	Cloned(Commentary)
53	Cofactor
11	Crystallization (Commentary)
2058	Disease/ Diagnostics
3	Expression
13	General Information
7	General Stability
16	IC50 Value
116	Inhibitors
5	kcat/KM [mM/s]
8	Ki Value [mM]
56	KM Value [mM]
28	Localization
23	Metals/Ions
26	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
92	Organism
10	Pathway
118	PDB ID
12	pH Optimum
1	pH Range
1	pH Stability
18	Posttranslational Modification
64	Protein Variants
17	Purification (Commentary)
9	Reaction
3	Reaction Type
92	Reference
1	Renatured (Commentary)
51	Source Tissue
30	Specific Activity [micromol/min/mg]
7	Storage Stability
83	Substrates and Products (Substrate)
21	Subunits
106	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
45	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.2.4.1 - pyruvate dehydrogenase (acetyl-transferring)

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

pyruvate + CoA + NAD+

acetyl-CoA + CO2 + NADH

9 entries

pyruvate + lipoamide

S-acetyldihydrolipoamide + CO2

11 entries

pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

[dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2

Arabidopsis thaliana

-

-

740976

-

-

?

pyruvate + [dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine

[dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2

Escherichia coli

-

-

654734

-

-

?

additional information

?

-

5 entries

pyruvate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Arabidopsis thaliana

-

-

657068

-

-

?

pyruvate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Escherichia coli

-

-

654734

-

-

?

pyruvate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Escherichia coli

P0AFG8

enzyme E1 is a component of the pyruvate dehydrogenase multienzyme complex PDHc, and catalyzes the first step of the multistep process

654741

-

-

?

pyruvate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Escherichia coli

P0AFG8

reaction of the citric acid or Krebs cycle

654647

-

-

?

pyruvate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Geobacillus stearothermophilus

-

first step of the overall reaction of the pyruvate dehydrogenase complex

655474

-

-

ir

pyruvate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Homo sapiens

-

-

698954

-

-

?

pyruvate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Homo sapiens

P08559

-

710839

-

-

?

pyruvate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Mus musculus

-

-

710839

-

-

?

pyruvate + CoA + NAD+

acetyl-CoA + CO2 + NADH

Rattus norvegicus

-

enzyme is the E1alpha component of the pyruvate dehydrogenase multienzyme complex, regulation via reversible phosphorylation, age-related in crease in enzyme E1alpha activity due to age-related decline in pyruvate dehydrogenase kinase PDK-4, overview

654462

-

-

?

pyruvate + lipoamide

S-acetyldihydrolipoamide + CO2

Ascaris lumbricoides

-

additional reactions of complex, e. g. reduction of K3Fe(CN)6

348968

-

348968

?

pyruvate + lipoamide

S-acetyldihydrolipoamide + CO2

Bos taurus

-

specific for

348955

-

348955

?

pyruvate + lipoamide

S-acetyldihydrolipoamide + CO2

Escherichia coli

-

in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate

348981

-

348981

?

pyruvate + lipoamide

S-acetyldihydrolipoamide + CO2

Escherichia coli

-

additional reactions of complex, e. g. reduction of K3Fe(CN)6

348981

-

348981

?

pyruvate + lipoamide

S-acetyldihydrolipoamide + CO2

Hansenula sp.

-

additional reactions of complex, e. g. reduction of K3Fe(CN)6

348949

-

348949

?

pyruvate + lipoamide

S-acetyldihydrolipoamide + CO2

Homo sapiens

-

-

348922

-

348922

ir

pyruvate + lipoamide

S-acetyldihydrolipoamide + CO2

Pisum sativum

-

in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by hydroxypyruvate

348936

-

348936

?

pyruvate + lipoamide

S-acetyldihydrolipoamide + CO2

Sus scrofa

-

in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate

348974

-

348974

?

pyruvate + lipoamide

S-acetyldihydrolipoamide + CO2

Sus scrofa

-

low reactivity with 2-ketovalerate

348974

-

348974

?

pyruvate + lipoamide

S-acetyldihydrolipoamide + CO2

Sus scrofa

-

low reactivity with 2-ketoisovalerate

348974

-

348974

?

pyruvate + lipoamide

S-acetyldihydrolipoamide + CO2

Sus scrofa

-

low reactivity with 2-ketoisocaproate

348974

-

348974

?

additional information

?

-

Arabidopsis thaliana

-

conjugates of indole-3-acetic acid with amino acids act as hormones and e.g. inhibit root elongation, the sensitivity of the mutant iar4-1 plant against these conjugates and plant hormones is reduced compared to the wild-type, overview

657068

-

-

?

additional information

?

-

Beta vulgaris

-

enzyme is essential for the tricatrboxylic cycle

657000

-

-

?

additional information

?

-

Escherichia coli

-

overall reaction of the multienzyme complex, overview

654734

-

-

?

additional information

?

-

Rattus norvegicus

-

determination of free short-chain CoA esters in rat heart

654462

-

-

?

additional information

?

-

Serratia marcescens

-

regulatory role of pirin in the process of pyruvate catabolism through interaction with enzyme and inhibition of pyruvate dehydrogenase complex

674315

-

-

?