1.2.7.1: pyruvate synthase

This is an abbreviated version!
For detailed information about pyruvate synthase, go to the full flat file.

Reaction

Synonyms

2-ketobutyrate synthase, 2-oxobutyrate (methylviologen), 2-oxobutyrate synthase (benzylviologen), 2-oxobutyrate-ferredoxin oxidoreductase, alpha-ketobutyrate synthase, alpha-ketobutyrate-ferredoxin oxidoreductase, AP120, Ape2126/2128, bifunctional pyruvate decarboxylase/pyruvate ferredoxin oxidoreductase, EC 1.2.7.2, Moth_0064, NifJ1, OFOR, PFO, PFO A, PFOR, Pfor1, PforA, PFR, PFR1, POR, PorEDABG, pyruvate ferredoxin oxidoreductase, pyruvate-ferredoxin oxidoreductase, pyruvate:Fd oxidoreductase, pyruvate:ferredoxin oxidoreductase, pyruvate:ferredoxin oxidoreductase A, synthase, 2-oxobutyrate, TKV_c04340, Tsac_0046, TTE0445

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.7 With an iron-sulfur protein as acceptor

                1.2.7.1 pyruvate synthase

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Results	in table
4	Activating Compound
5606	AA Sequence
6	Application
8	Cloned(Commentary)
27	Cofactor
2	Crystallization (Commentary)
3	Expression
18	General Information
4	General Stability
2	IC50 Value
27	Inhibitors
19	kcat/KM [mM/s]
4	Ki Value [mM]
51	KM Value [mM]
7	Localization
10	Metals/Ions
65	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
108	Organism
12	Oxidation Stability
37	Pathway
23	PDB ID
20	pH Optimum
5	pH Range
22	Purification (Commentary)
1	Reaction
72	Reference
9	Source Tissue
24	Specific Activity [micromol/min/mg]
6	Storage Stability
127	Substrates and Products (Substrate)
35	Subunits
84	Synonyms
1	Systematic Name
29	Temperature Optimum [°C]
7	Temperature Range [°C]
10	Temperature Stability [°C]
7	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.2.7.1 - pyruvate synthase

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SYSTEMATIC NAME

IUBMB Comments

pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)

Contains thiamine diphosphate and [4Fe-4S] clusters. The enzyme also decarboxylates 2-oxobutyrate with lower efficiency, but shows no activity with 2-oxoglutarate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.3, 2-oxoglutarate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).