1.2.7.4: anaerobic carbon-monoxide dehydrogenase
This is an abbreviated version!
For detailed information about anaerobic carbon-monoxide dehydrogenase, go to the full flat file.
Word Map on EC 1.2.7.4
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1.2.7.4
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co2
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codhs
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nickel
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acetogenic
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thermoaceticum
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rubrum
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rhodospirillum
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methanosarcina
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carboxydothermus
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hydrogenoformans
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carboxidovorans
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c-clusters
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oligotropha
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wood-ljungdahl
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co-dependent
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methanogenesis
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carboxydotrophic
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co-oxidizing
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hydrogenases
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barkeri
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sulfate-reducing
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nickel-dependent
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acetobacterium
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nifes
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molybdenum-containing
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hydrogenogenic
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acetogenesis
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nickel-containing
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syngas
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methyl-coenzyme
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moorella
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square-planar
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homoacetogenic
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overpotential
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acetate-grown
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fe-containing
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electrocatalysts
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analysis
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hydrogenophaga
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methyltetrahydrofolate
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cubane-type
- 1.2.7.4
- co2
-
codhs
- nickel
-
acetogenic
- thermoaceticum
- rubrum
- rhodospirillum
- methanosarcina
- carboxydothermus
- hydrogenoformans
- carboxidovorans
-
c-clusters
-
oligotropha
-
wood-ljungdahl
-
co-dependent
-
methanogenesis
-
carboxydotrophic
-
co-oxidizing
- hydrogenases
- barkeri
-
sulfate-reducing
-
nickel-dependent
- acetobacterium
-
nifes
-
molybdenum-containing
-
hydrogenogenic
-
acetogenesis
-
nickel-containing
-
syngas
-
methyl-coenzyme
- moorella
-
square-planar
-
homoacetogenic
-
overpotential
-
acetate-grown
-
fe-containing
-
electrocatalysts
- analysis
-
hydrogenophaga
- methyltetrahydrofolate
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cubane-type
Reaction
Synonyms
acetyl coenzyme A synthase/carbon monoxide dehydrogenase, acetyl-CoA synthase/carbon monoxide dehydrogenase, ACS/CODH, Carbon dioxide/carbon monoxide oxidoreductase, Carbon monoxide dehydrogenase, carbon monoxide dehydrogenase-corrinoid enzyme complex, carbon monoxide dehydrogenase/acetyl-CoA synthase, Carbon monoxide oxidoreductase, Cdh, CO dehydrogenase, CO dehydrogenase complex, CO dehydrogenase complex II, CO dehydrogenase II, CO dehydrogenase/acetyl-CoA synthase, Co-DG, CO-DH, CODH, CODH II, CODH-II, CODH/ACS, CODHACS, CODHase, CODHII, coos, Dehydrogenase, carbon monoxide, EC 1.2.99.2, monoxide dehydrogenase/acetyl-CoA synthase, Ni,Fe-CODH, Ni,Fe-dependent carbon monoxide dehydrogenase, Ni-CODH, Ni-containing carbon monoxide dehydrogenase, Ni-Fe carbon monoxide dehydrogenase II
ECTree
1.2.7.4 anaerobic carbon-monoxide dehydrogenaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 1.2.7.4 - anaerobic carbon-monoxide dehydrogenase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
1,10-phenanthroline
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1 mM, inactivates CO/acetyl-CoA exchange activity completely but has no effect on CO oxidation
COS
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rapid-equilibrium inhibitor largely competitive versus CO, uncompetitive versus methyl viologen
D-glucose
Roseibium aggregatum
partially inhibited by incubation with 0.5 mM exogenous D-glucose
Glyoxaldehyde
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inactivation requires enzymatic turnover; only with CO and methyl viologen as substrates
potassium cyanide
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competitive inhibitor of reduced CODHII with respect to the substrate CO, inhibition of dithionite- or Ti(III) citrate-reduced CODHII by potassium cyanide is fully reversible since the enzyme can be completely reactivated, sodium sulfide has no effect on the reactivation of cyanide-inhibited CODHII in the presence of dithionite
CN-
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0.2 mM, 17% inhibition in the presence of air, 32% CO and 69% N2, inhibition can be removed by O2 or CO
CN-
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CO, CO2 and COS reverse inhibition; dithionite slows the inhibition, but cannot reactivate the enzyme
CN-
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CO and COS protect from inhibition; CO, CO2 and COS reverse inhibition
CO
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substrate inhibition. Increasing CO concentrations in the gas phase inhibit CODH activity
cyanide
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0.075 mM, reversible, competitive inhibition of reduced CODHII with respect to the substrate carbon monoxide, which protects reduced CODHII against inhibition by cyanide, inhibited CODHII regains initial activity after a 15-25-min incubation at 70°C with dithionite or Ti(III) citrate under CO or N2, while slower and partial reactivation to 30-50% of the initial activity occurs with dithiothreitol or without reductants
KCN
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CO reverses cyanide inhibition, but promotes reaction with methyl iodide
additional information
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dimethylglyoxime is no inhibitor, formaldehyde and acetaldehyde does not inactivate the enzyme; not inhibited by 20 mM formaldehyde or acetaldehyde
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additional information
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not affected by propyl iodide, methyl iodide, carbon tetrachloride,or metal chelators; not inhibited by propyl iodide, methyl iodide, carbon tetrachloride, EDTA or nitrilotriacetate
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additional information
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phenylglyoxal, methylglyoxal, butanedione, mersalyl acid, methyl iodide, 5,5'-dithiobis (2-nitrobenzoate) and sodium dithionite inhibits the exchange reaction between CO and acetyl-CoA
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additional information
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inhibition data are interpreted in terms of two binding sites for CO on CO dehydrogenase
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