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1.2.7.4: anaerobic carbon-monoxide dehydrogenase

This is an abbreviated version!
For detailed information about anaerobic carbon-monoxide dehydrogenase, go to the full flat file.

Word Map on EC 1.2.7.4

Reaction

CO
+
H2O
+ 2 oxidized ferredoxin =
CO2
+ 2 reduced ferredoxin + 2 H+

Synonyms

acetyl coenzyme A synthase/carbon monoxide dehydrogenase, acetyl-CoA synthase/carbon monoxide dehydrogenase, ACS/CODH, Carbon dioxide/carbon monoxide oxidoreductase, Carbon monoxide dehydrogenase, carbon monoxide dehydrogenase-corrinoid enzyme complex, carbon monoxide dehydrogenase/acetyl-CoA synthase, Carbon monoxide oxidoreductase, Cdh, CO dehydrogenase, CO dehydrogenase complex, CO dehydrogenase complex II, CO dehydrogenase II, CO dehydrogenase/acetyl-CoA synthase, Co-DG, CO-DH, CODH, CODH II, CODH-II, CODH/ACS, CODHACS, CODHase, CODHII, coos, Dehydrogenase, carbon monoxide, EC 1.2.99.2, monoxide dehydrogenase/acetyl-CoA synthase, Ni,Fe-CODH, Ni,Fe-dependent carbon monoxide dehydrogenase, Ni-CODH, Ni-containing carbon monoxide dehydrogenase, Ni-Fe carbon monoxide dehydrogenase II

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.7 With an iron-sulfur protein as acceptor
                1.2.7.4 anaerobic carbon-monoxide dehydrogenase

Oxidation Stability

Oxidation Stability on EC 1.2.7.4 - anaerobic carbon-monoxide dehydrogenase

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OXIDATION STABILITY
ORGANISM
UNIPROT
LITERATURE
100% of activity remains after 48 h of oxygen exposure, and after 168 h of air exposure, activity is 88% of the initial activity
-
725052
addition of the enzyme to an aerobic buffer, 50 mM Tris/HCl, pH 7.6 results in a 98% loss of activity within 15 min, presence of CO has no apparent effect on the stability of the enzyme
-
390452
enzymatic activity is destroyed by air, a low amount of activity still is present after 2 h exposure to air
-
390454
extreme oxygen lability
extremely oxygen-labile, even in N2 atmosphere with less than 5 ppm O2 the pure enzyme loses a significant amount of its activity within 18 h, 2 mM dithionite protects from inactivation
-
390450
extremely sensitive to air, most of the enzyme activity is lost upon exposure to air for 1 min, longer incubation results in complete inactivation
-
390449
oxygen stable, 10% loss in activity after 72 h exposure to air at 4°C
-
390473
Oxygen treatment results in an activity loss of 90% within 30 min. Treatment of oxygen-inactivated enzyme with CO, H2, or dithionite does not restore activity
-
727713
strong inhibition by oxygen, extremely sensitive, exposed to air activity is lost in less than 1 min
-
390449