1.2.7.7: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)

This is an abbreviated version!
For detailed information about 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin), go to the full flat file.

Reaction

Synonyms

2-ketoisovalerate ferredoxin oxidoreductase, 2-oxoisovalerate ferredoxin reductase, 2-oxoisovalerate oxidoreductase, 2-oxoisovalerate:ferredoxin oxidoreductase, 3-methyl-2-oxobutanoate dehydrogenase, 3-methyl-2-oxobutanoate synthase (ferredoxin), branched-chain ketoacid ferredoxin reductase, branched-chain oxo acid ferredoxin reductase, keto-valine-ferredoxin oxidoreductase, ketoisovalerate ferredoxin reductase, VOR

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.7 With an iron-sulfur protein as acceptor

                1.2.7.7 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)

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Results	in table
10	Activating Compound
1629	AA Sequence
4	Application
1	CAS Registry Number
2	Cloned(Commentary)
2	Cofactor
2	Inhibitors
28	KM Value [mM]
9	Metals/Ions
26	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
27	Organism
2	Oxidation Stability
14	Pathway
3	pH Optimum
1	pH Stability
7	Purification (Commentary)
16	Reaction
2	Reaction Type
19	Reference
7	Specific Activity [micromol/min/mg]
121	Substrates and Products (Substrate)
12	Subunits
16	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
3	Temperature Range [°C]
2	Temperature Stability [°C]
24	Turnover Number [1/s]

Reference

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Reference on EC 1.2.7.7 - 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

288443

Kletzin, A.; Adams, M.W.W.

Molecular and phylogenetic chararcterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima

J. Bacteriol.

178

248-257

1996

Pyrococcus furiosus

8550425

brenda

639362

Schut, G.J.; Menon, A.L.; Adams, M.W.W.

2-Keto acid oxidoreductases from Pyrococcus furiosus and Thermococcus litoralis

Methods Enzymol.

331

144-158

2001

Pyrococcus furiosus, Thermococcus litoralis

11265457

brenda

644696

Heider, J.; Mai, X.; Adams, M.W.

Characterization of 2-ketoisovalerate ferredoxin oxidoreductase, a new and reversible coenzyme A-dependent enzyme involved in peptide fermentation by hyperthermophilic archaea

J. Bacteriol.

178

780-787

1996

Pyrococcus sp., Pyrococcus furiosus, Thermococcus litoralis, Thermococcus sp., Pyrococcus sp. ES-4, Thermococcus sp. ES-1

8550513

brenda

644697

Tersteegen, A.; Linder, D.; Thauer, R.K.; Hedderich, R.

Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum

Eur. J. Biochem.

244

862-868

1997

Methanothermobacter thermautotrophicus, Pyrococcus furiosus, Thermococcus litoralis

9108258

brenda

680533

Ozawa, Y.; Nakamura, T.; Kamata, N.; Yasujima, D.; Urushiyama, A.; Yamakura, F.; Ohmori, D.; Imai, T.

Thermococcus profundus 2-ketoisovalerate ferredoxin oxidoreductase, a key enzyme in the archaeal energy-producing amino acid metabolic pathway

J. Biochem.

137

101-107

2005

Thermococcus profundus

15713889

brenda

736364

Nohara, K.; Orita, I.; Nakamura, S.; Imanaka, T.; Fukui, T.

Genetic examination and mass balance analysis of pyruvate/amino acid oxidation pathways in the hyperthermophilic archaeon Thermococcus kodakarensis

J. Bacteriol.

196

3831-3839

2014

Thermococcus kodakarensis, Thermococcus kodakarensis KUW1

25157082

brenda

736738

Lin, P.; Mi, L.; Morioka, A.; Yoshino, K.; Konishi, S.; Xu, S.; Papanek, B.; Riley, L.; Guss, A.; Liao, J.

Consolidated bioprocessing of cellulose to isobutanol using Clostridium thermocellum

Metab. Eng.

31

44-52

2015

Acetivibrio thermocellus, Acetivibrio thermocellus DSM 1313

26170002

brenda

763062

Weitz, S.; Hermann, M.; Linder, S.; Bengelsdorf, F.; Takors, R.; Duerre, P.

Isobutanol production by autotrophic acetogenic bacteria

Front. Bioeng. Biotechnol.

9

657253

2021

Acetivibrio thermocellus, Acetivibrio thermocellus DSM 1313

33912549

brenda

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