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1.20.4.4: arsenate reductase (thioredoxin)

This is an abbreviated version!
For detailed information about arsenate reductase (thioredoxin), go to the full flat file.

Word Map on EC 1.20.4.4

Reaction

arsenate
+
thioredoxin
=
arsenite
 +
thioredoxin disulfide
 +
H2O

Synonyms

ARS, ArsC, ArsC1, ArsC1', ArsC3, arsenate reductase, Bs_ArsC, pI258 arsenate reductase, plasmid pI258 arsenate reductase, Sa_ArsC, Strop634, thioredoxin-arsenate reductase complex, thioredoxin-coupled arsenate reductase, Trx-coupled arsenate reductase

ECTree

     1 Oxidoreductases
         1.20 Acting on phosphorus or arsenic in donors
             1.20.4 With disulfide as acceptor
                1.20.4.4 arsenate reductase (thioredoxin)

Inhibitors

Inhibitors on EC 1.20.4.4 - arsenate reductase (thioredoxin)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
antimonite
SbO2-, pH 7.5, 37°C
arsenite
pH 7.5, 37°C
iodoacetate
sulfhydryl inhibitors N-ethylmaleimide -and iodoacetate inhibit arsenate reductase activity by 80% in crude cell-free preparations and by 90% with purified ArsC protein
N-ethylmaleimide
sulfhydryl inhibitors N-ethylmaleimide -and iodoacetate inhibit arsenate reductase activity by 80% in crude cell-free preparations and by 90% with purified ArsC protein
tellurite
pH 7.5, 37°C
additional information
arsenite, tellurite, and antimonite [Sb(III)] are inhibitors for NADPH oxidation; the substrate, arsenate, is not inhibitory at concentrations up to 40 mM
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