1.21.1.1: iodotyrosine deiodinase

This is an abbreviated version!
For detailed information about iodotyrosine deiodinase, go to the full flat file.

Word Map on EC 1.21.1.1

1.21.1.1

thyroid

iodide

deiodination

hypothyroidism

diiodotyrosine

thyroglobulin

dehalogenation

halotyrosines

iodothyronine

nitroreductase

goiter

bromo

chlorotyrosine

organification

diagnostics

synthesis

medicine

Reaction

Synonyms

DEHAL1, Dehal1 protein, DEHAL1B, EC 1.22.1.1, iodotyrosine dehalogenase 1, iodotyrosine deiodinase, IYD, lyd, NADH oxidase/flavin reductase, SUP-18, SUP-18 IYD, TDH

ECTree

1 Oxidoreductases

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.1.1 iodotyrosine deiodinase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
7	Activating Compound
892	AA Sequence
4	Application
12	Cloned(Commentary)
25	Cofactor
5	Crystallization (Commentary)
69	Disease/ Diagnostics
6	Expression
15	General Information
6	IC50 Value
38	Inhibitors
14	kcat/KM [mM/s]
25	KM Value [mM]
10	Localization
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
199	Organism
14	PDB ID
2	pH Optimum
1	pH Range
1	Posttranslational Modification
20	Protein Variants
10	Purification (Commentary)
3	Reaction
33	Reference
2	Renatured (Commentary)
35	Source Tissue
16	Specific Activity [micromol/min/mg]
2	Storage Stability
60	Substrates and Products (Substrate)
9	Subunits
22	Synonyms
1	Systematic Name
17	Turnover Number [1/s]

Application

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Application on EC 1.21.1.1 - iodotyrosine deiodinase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Application Search

diagnostics

Homo sapiens

Q6PHW0

improvement of pre-clinical detection of iodotyrosine deiodinase deficiency during the neonatal time

733237

medicine

Homo sapiens

study on enzyme expression in thyroid pathology. The highest DEHAL1 mRNA levels are found in Graves' disease thyroids, while downregulation of DEHAL1 and DEHAL1B mRNA occurrs in papillary thyroid carcinomas and anaplastic thyroid carcinomas. DEHAL1 protein is overexpressed in toxic thyroid nodules and Graves' disease thyroids with predominant apical staining in all samples. A weaker and patchy staining pattern is found in benign cold thyroid nodules and normal thyroids. In differentiated thyroid cancers such as follicular thyroid carcinomas and papillary thyroid carcinomas, a diffuse cytoplasmic DEHAL1 expression is found. In partially differentiated thyroid cancers and anaplastic thyroid carcinomas, DEHAL1 expression is faint or absent

703541

synthesis

Mus musculus

Q9DCX8

high expression of a truncated derivative lacking the membrane domain, residues 2-33, at its N-terminal is observed in Sf9 cells, whereas expression in Pichia pastoris remains low despite codon optimization. The desired expression in Escherichia coli can be achieved after replacing the two conserved Cys residues of the deiodinase with Ala and fusing the resulting protein to thioredoxin. This construct provides abundant enzyme for crystallography and mutagenesis

726449

additional information

2 entries