1.21.1.1: iodotyrosine deiodinase

This is an abbreviated version!
For detailed information about iodotyrosine deiodinase, go to the full flat file.

Word Map on EC 1.21.1.1

1.21.1.1

thyroid

iodide

deiodination

hypothyroidism

diiodotyrosine

thyroglobulin

dehalogenation

halotyrosines

iodothyronine

nitroreductase

goiter

bromo

chlorotyrosine

organification

diagnostics

synthesis

medicine

Reaction

Synonyms

DEHAL1, Dehal1 protein, DEHAL1B, EC 1.22.1.1, iodotyrosine dehalogenase 1, iodotyrosine deiodinase, IYD, lyd, NADH oxidase/flavin reductase, SUP-18, SUP-18 IYD, TDH

ECTree

1 Oxidoreductases

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.1.1 iodotyrosine deiodinase

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Results	in table
7	Activating Compound
892	AA Sequence
4	Application
12	Cloned(Commentary)
25	Cofactor
5	Crystallization (Commentary)
69	Disease/ Diagnostics
6	Expression
15	General Information
6	IC50 Value
38	Inhibitors
14	kcat/KM [mM/s]
25	KM Value [mM]
10	Localization
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
199	Organism
14	PDB ID
2	pH Optimum
1	pH Range
1	Posttranslational Modification
20	Protein Variants
10	Purification (Commentary)
3	Reaction
33	Reference
2	Renatured (Commentary)
35	Source Tissue
16	Specific Activity [micromol/min/mg]
2	Storage Stability
60	Substrates and Products (Substrate)
9	Subunits
22	Synonyms
1	Systematic Name
17	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 1.21.1.1 - iodotyrosine deiodinase

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109

stage 42, brain

118.6

stage 44, tail

125

stage 46, brain

138.5

stage 42, tail

157.7

stage 44, brain

17.9

stage 42, lower jaw

24.01

stage 44, lower jaw

28.4

stage 46, lower jaw

3100

pH 7.4, 25°C

stage 42, tail

6.1

stage 44, lower jaw

6.6

stage 46, lower jaw

65.8

stage 42, brain

7800

pH 7.4, 38°C

9.2

stage 44, brain

additional information

Elaphe taeniurus

activity ranges from 0.0001 to 0.0003 microg/min/mg of tissue

703835