1.21.3.3: reticuline oxidase

This is an abbreviated version!
For detailed information about reticuline oxidase, go to the full flat file.

Reaction

Synonyms

(S)-reticuline oxidase, BBE, BBE-like 13, BBE-like 15, BBE-like 28, BBE1, BBL, berberine bridge enzyme, berberine bridge enzyme-like, berberine bridge enzyme-like 28, berberine bridge-forming enzyme, berberine-bridge-forming enzyme, EC 1.5.3.9, flavin-dependent oxidase, monolignol oxidoreductase, reticuline oxidase, tetrahydroprotoberberine synthase

ECTree

     1 Oxidoreductases

         1.21 Catalysing the reaction X-H + Y-H = X-Y

             1.21.3 With oxygen as acceptor

                1.21.3.3 reticuline oxidase

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Results	in table
1	Activating Compound
48	AA Sequence
3	Application
1	CAS Registry Number
16	Cloned(Commentary)
12	Cofactor
6	Crystallization (Commentary)
1	Expression
2	General Information
13	Inhibitors
2	kcat/KM [mM/s]
7	KM Value [mM]
6	Localization
4	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
36	Organism
11	Pathway
13	PDB ID
5	pH Optimum
3	pH Range
2	Posttranslational Modification
14	Protein Variants
6	Purification (Commentary)
1	Reaction
7	Reaction Type
35	Reference
20	Source Tissue
4	Storage Stability
70	Substrates and Products (Substrate)
2	Subunits
40	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
14	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.21.3.3 - reticuline oxidase

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SYSTEMATIC NAME

IUBMB Comments

(S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming)

Contains FAD. The enzyme from the plant Eschscholtzia californica binds the cofactor covalently [3]. Acts on (S)-reticuline and related compounds, converting the N-methyl group into the methylene bridge ('berberine bridge') of (S)-tetrahydroprotoberberines. The product of the reaction, (S)-scoulerine, is a precursor of protopine, protoberberine and benzophenanthridine alkaloid biosynthesis in plants.