1.21.3.7: tetrahydrocannabinolic acid synthase

This is an abbreviated version!
For detailed information about tetrahydrocannabinolic acid synthase, go to the full flat file.

Word Map on EC 1.21.3.7

1.21.3.7

cannabis

cannabinoids

cannabigerolic

psychoactive

cannabidiolic

forensic

drug-type

chemotype

hemp

cbcas

fiber-type

marijuana

komagataella

seized

cannabichromenic

Reaction

Synonyms

DELA1-THCA synthase, DELTA1-tetrahydrocannabinolic acid synthase, DELTA9-tetrahydrocannabinolic acid synthase, tetrahydrocannabinolic acid synthase, tetrahydrocannabinolic acid-synthase, tetrahydrocannabinolic-acid synthase, THCA synthase, THCA-synthase, THCAS

ECTree

1 Oxidoreductases

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.3 With oxygen as acceptor

1.21.3.7 tetrahydrocannabinolic acid synthase

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Results	in table
1	Activating Compound
3	AA Sequence
11	Cloned(Commentary)
8	Cofactor
2	Crystallization (Commentary)
1	Expression
2	General Information
3	Inhibitors
4	kcat/KM [mM/s]
7	KM Value [mM]
1	Localization
2	Metals/Ions
11	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
18	Organism
4	Pathway
1	pH Optimum
1	pI Value
5	Posttranslational Modification
10	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
18	Reference
9	Source Tissue
2	Specific Activity [micromol/min/mg]
18	Substrates and Products (Substrate)
16	Subunits
37	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

Engineering

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Engineering on EC 1.21.3.7 - tetrahydrocannabinolic acid synthase

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Go to Protein Variants Search

E442Q

Cannabis sativa

the enzyme shows 85% of wild type activity

H114A

H208A

the mutant shows 94% wild type activity

719821

H292A

Cannabis sativa

the enzyme shows 5% of wild type activity

720263

H92A

Cannabis sativa

Q8GTB6

the mutant shows 87% wild type activity

719821

R108A

Cannabis sativa

Q8GTB6

the mutant shows 13% wild type activity

719821

R110A

Cannabis sativa

Q8GTB6

the mutant shows 10% wild type activity

719821

Y417F

Cannabis sativa

the enzyme shows 42% of wild type activity

720263

Y484F

Cannabis sativa

the mutation completely abolishes enzymatic activity

720263