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1.21.4.2: glycine reductase

This is an abbreviated version!
For detailed information about glycine reductase, go to the full flat file.

Word Map on EC 1.21.4.2

Reaction

acetyl phosphate
+
NH3
+
thioredoxin disulfide
+
H2O
=
glycine
+
phosphate
+
thioredoxin

Synonyms

glycine reductase, GrdA

ECTree

     1 Oxidoreductases
         1.21 Catalysing the reaction X-H + Y-H = X-Y
             1.21.4 With a disulfide as acceptor
                1.21.4.2 glycine reductase

Reference

Reference on EC 1.21.4.2 - glycine reductase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bednarski, B.; Andreesen, J.R.; Pich, A.
In vitro processing of the proproteins GrdE of protein B of glycine reductase and PrdA of D-proline reductase from Clostridium sticklandii: formation of a pyruvoyl group from a cysteine residue
Eur. J. Biochem.
268
3538-3544
2001
Acetoanaerobium sticklandii (P26971), Acetoanaerobium sticklandii, Acetoanaerobium sticklandii DSM 519 (P26971)
Manually annotated by BRENDA team
Wagner, M.; Sonntag, D.; Grimm, R.; Pich, A.; Eckerskorn, C.; Söhling, B.; Andreesen, J.R.
Substrate-specific selenoprotein B of glycine reductase from Eubacterium acidaminophilum
Eur. J. Biochem.
260
38-49
1999
Peptoclostridium acidaminophilum (Q9R4G7), Peptoclostridium acidaminophilum
Manually annotated by BRENDA team
Tanaka, H.; Stadtman, T.C.
Selenium-dependent clostridial glycine reductase. Purification and characterization of the two membrane-associated protein components
J. Biol. Chem.
254
447-452
1979
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Sliwkowski, M.X.; Stadtman, T.C.
Selenium-dependent glycine reductase: differences in physicochemical properties and biological activities of selenoprotein A components isolated from Clostridium sticklandii and Clostridium purinolyticum
Biofactors
1
293-296
1988
Gottschalkia purinilytica, Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Sliwkowski, M.X.; Stadtman, T.C.
Selenoprotein A of the clostridial glycine reductase complex: purification and amino acid sequence of the selenocysteine-containing peptide
Proc. Natl. Acad. Sci. USA
85
368-371
1988
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Stadtman, T.C.
Clostridial glycine reductase: protein C, the acetyl group acceptor, catalyzes the arsenate-dependent decomposition of acetyl phosphate
Proc. Natl. Acad. Sci. USA
86
7853-7856
1989
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Garcia, G.E.; Stadtman, T.C.
Selenoprotein A component of the glycine reductase complex from Clostridium purinolyticum: nucleotide sequence of the gene shows that selenocysteine is encoded by UGA
J. Bacteriol.
173
2093-2098
1991
Gottschalkia purinilytica
Manually annotated by BRENDA team
Stadtman, T.C.; Davis, J.N.
Glycine reductase protein C. Properties and characterization of its role in the reductive cleavage of Se-carboxymethyl-selenoprotein A
J. Biol. Chem.
266
22147-22153
1991
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Kimura, Y.; Stadtman, T.C.
Glycine reductase selenoprotein A is not a glycoprotein: the positive periodic acid-Schiff reagent test is the result of peptide bond cleavage and carbonyl group generation
Proc. Natl. Acad. Sci. USA
92
2189-2193
1995
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Dietrichs, D.; Meyer, M.; Rieth, M.; Andreesen, J.R.
Interaction of selenoprotein PA and the thioredoxin system, components of the NADPH-dependent reduction of glycine in Eubacterium acidaminophilum and Clostridium litorale. [Erratum to document cited in CA116(1):2789b]
J. Bacteriol.
173
5983-5991
1992
Peptoclostridium litorale, Peptoclostridium acidaminophilum
Manually annotated by BRENDA team
Schraeder, T.; Andreesen, J.R.
Purification and characterization of protein PC, a component of glycine reductase from Eubacterium acidaminophilum
Eur. J. Biochem.
206
79-85
1992
Peptoclostridium acidaminophilum
Manually annotated by BRENDA team
Kohlstock, U.M.; Rucknagel, K.P.; Reuter, M.; Schierhorn, A.; Andreesen, J.R.; Sohling, B.
Cys359 of GrdD is the active-site thiol that catalyses the final step of acetyl phosphate formation by glycine reductase from Eubacterium acidaminophilum
Eur. J. Biochem.
268
6417-6425
2001
Peptoclostridium acidaminophilum
Manually annotated by BRENDA team
Kreimer, S.; Andreesen, J.R.
Glycine reductase of Clostridium littorale. Cloning, sequencing, and molecular analysis of the grdAB operon that contains two in-frame TGA codons for selenium incorporation
Eur. J. Biochem.
234
192-199
1995
Peptoclostridium litorale
Manually annotated by BRENDA team
Schneeberger, A.; Frings, J.; Schink, B.
Net synthesis of acetate from CO2 by Eubacterium acidaminophilum through the glycine reductase pathway
FEMS Microbiol. Lett.
177
1-6
1999
Peptoclostridium acidaminophilum, Peptoclostridium acidaminophilum al-2
-
Manually annotated by BRENDA team
Arkowitz, R.A.; Abeles, R.H.
Mechanism of action of clostridial glycine reductase: isolation and characterization of a covalent acetyl enzyme intermediate
Biochemistry
30
4090-4097
1991
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Rother, M.; Bock, A.; Wyss, C.
Selenium-dependent growth of Treponema denticola: evidence for a clostridial-type glycine reductase
Arch. Microbiol.
177
113-116
2001
Treponema denticola, Treponema denticola CDK
Manually annotated by BRENDA team
Andreesen, J.R.
Glycine reductase mechanism
Curr. Opin. Chem. Biol.
8
454-461
2004
Acetoanaerobium sticklandii, Peptoclostridium acidaminophilum, Tissierella creatinophila, Treponema denticola
Manually annotated by BRENDA team
Groebe, T.; Reuter, M.; Gursinsky, T.; Soehling, B.; Andreesen, J.R.
Peroxidase activity of selenoprotein GrdB of glycine reductase and stabilisation of its integrity by components of proprotein GrdE from Eubacterium acidaminophilum
Arch. Microbiol.
187
29-43
2007
Peptoclostridium acidaminophilum
Manually annotated by BRENDA team
Jackson, S.; Calos, M.; Myers, A.; Self, W.T.
Analysis of proline reduction in the nosocomial pathogen Clostridium difficile
J. Bacteriol.
188
8487-8495
2006
Clostridioides difficile
Manually annotated by BRENDA team
Wanchanthuek, P.; Bellgard, M.; La, T.; Ryan, K.; Moolhuijzen, P.; Chapman, B.; Black, M.; Schibeci, D.; Hunter, A.; Barrero, R.; Phillips, N.; Hampson, D.
The complete genome sequence of the pathogenic intestinal spirochete Brachyspira pilosicoli and comparison with other Brachyspira genomes
PLoS ONE
5
e11455
2010
Brachyspira pilosicoli
Manually annotated by BRENDA team
Bouillaut, L.; Self, W.T.; Sonenshein, A.L.
Proline-dependent regulation of Clostridium difficile Stickland metabolism
J. Bacteriol.
195
844-854
2013
Clostridioides difficile (Q185M6), Clostridioides difficile, Clostridioides difficile 630 (Q185M6)
Manually annotated by BRENDA team