1.21.99.4: thyroxine 5'-deiodinase

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For detailed information about thyroxine 5'-deiodinase, go to the full flat file.

Reaction

Synonyms

5DI , 5DII , 5DIII , D1 5'-deiodinase, D2 5'-deiodinase, deiodinase, diiodothyronine 5'-deiodinase, Dio, DIO1, DIO2, DIOI , DIOII , DIOIII , EC 1.97.1.10, EC 3.8.1.4, ID-1, ID-2, ID-3, iodothyronine 5'-deiodinase, Iodothyronine 5'-monodeiodinase, iodothyronine 5-deiodinase, iodothyronine deiodinase 2, iodothyronine deiodinase D2, iodothyronine inner ring monodeiodinase, iodothyronine outer ring monodeiodinase, L-thyroxine iodohydrolase (reducing), thyroxine 5-deiodinase, Thyroxine deiodinase, type 1 5'-deiodinase, type 1 deiodinase, Type 1 DI , type 1 iodothyronine deiodinase, type 2 5'-deiodinase, type 2 deiodinase, Type 2 DI , type 2 iodothyronine deiodinase, type 3 deiodinase, Type 3 DI , type I iodothyronine 5'-deiodinase, type I iodothyronine deiodinase, type I-like deiodinase, type II iodothyronine deiodinase, type II-like deiodinase, Type-I 5'deiodinase , Type-II 5'deiodinase , Type-III 5'deiodinase , types 1 iodothyronine selenodeiodinase, types 2 iodothyronine selenodeiodinase, XL-15

ECTree

     1 Oxidoreductases

         1.21 Catalysing the reaction X-H + Y-H = X-Y

             1.21.99 With unknown physiological acceptors

                1.21.99.4 thyroxine 5'-deiodinase

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Results	in table
59	Activating Compound
30	AA Sequence
8	Application
1	CAS Registry Number
19	Cloned(Commentary)
18	Cofactor
908	Disease/ Diagnostics
22	Expression
16	General Information
4	General Stability
26	IC50 Value
91	Inhibitors
79	KM Value [mM]
35	Localization
7	Metals/Ions
12	Molecular Weight [Da]
71	Natural Substrates/ Products (Substrates)
239	Organism
2	Pathway
17	pH Optimum
1	pH Range
4	Posttranslational Modification
15	Protein Variants
4	Purification (Commentary)
16	Reaction
2	Reaction Type
94	Reference
1	Renatured (Commentary)
213	Source Tissue
54	Specific Activity [micromol/min/mg]
1	Storage Stability
127	Substrates and Products (Substrate)
19	Subunits
118	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
3	Temperature Stability [°C]
3	Turnover Number [1/s]

General Stability

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General Stability on EC 1.21.99.4 - thyroxine 5'-deiodinase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

activity mostly lost during purification procedures, catalytic activity lost in detergent solution

Rattus sp.

-

639407, 639417

very short lifetime in vivo of isoenzyme type II (D2) from brain

Rattus sp.

-

639403, 639404