1.21.99.4: thyroxine 5'-deiodinase
This is an abbreviated version!
For detailed information about thyroxine 5'-deiodinase, go to the full flat file.
Word Map on EC 1.21.99.4
-
1.21.99.4
-
thyroid
-
triiodothyronine
-
hypothyroidism
-
tsh
-
deiodination
-
adipose
-
pituitary
-
selenium
-
euthyroidism
-
selenoproteins
-
3,5,3'-triiodothyronine
-
thyrotropin
-
prohormone
-
thermogenesis
-
selenoenzyme
-
propylthiouracil
-
photoperiodic
-
hypothalamic
-
hypothalamic-pituitary-thyroid
-
selenocysteine
-
thyroid-stimulating
-
thyrotropin-releasing
-
iopanoic
-
thermogenic
-
iodotyrosine
-
hypophysiotropic
-
t3-dependent
-
polybrominated
-
extrathyroidal
-
hypothyroxinemia
-
3,3',5-triiodothyronine
-
thyroxine-binding
-
mediobasal
-
pbdes
-
5'-deiodination
-
iodine-deficient
-
tanycytes
-
tuberalis
-
debromination
-
selenocysteine-containing
-
trbeta
-
methimazole
-
thyrotoxicosis
-
hormone-activating
-
thyroperoxidase
-
monocarboxylate
-
nonthyroidal
-
secis
-
levothyroxine
-
medicine
-
selenium-deficient
- 1.21.99.4
- thyroid
- triiodothyronine
- hypothyroidism
- tsh
-
deiodination
- adipose
- pituitary
- selenium
-
euthyroidism
-
selenoproteins
- 3,5,3'-triiodothyronine
- thyrotropin
-
prohormone
-
thermogenesis
-
selenoenzyme
- propylthiouracil
-
photoperiodic
- hypothalamic
-
hypothalamic-pituitary-thyroid
- selenocysteine
-
thyroid-stimulating
-
thyrotropin-releasing
-
iopanoic
-
thermogenic
- iodotyrosine
-
hypophysiotropic
-
t3-dependent
-
polybrominated
-
extrathyroidal
-
hypothyroxinemia
- 3,3',5-triiodothyronine
-
thyroxine-binding
-
mediobasal
-
pbdes
-
5'-deiodination
-
iodine-deficient
- tanycytes
- tuberalis
-
debromination
-
selenocysteine-containing
-
trbeta
- methimazole
- thyrotoxicosis
-
hormone-activating
- thyroperoxidase
-
monocarboxylate
-
nonthyroidal
-
secis
- levothyroxine
- medicine
-
selenium-deficient
Reaction
Synonyms
5DI
ECTree
1.21.99.4 thyroxine 5'-deiodinaseAdvanced search results
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Reference on EC 1.21.99.4 - thyroxine 5'-deiodinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Goswami, A.; Leonard, J.L.; Rosenberg, I.N.
Inhibition by coumardin anticoagulants of enzymatic outer ring monodeiodination of iodothyronines
Biochem. Biophys. Res. Commun.
104
1231-1238
1982
Rattus sp.
Koehrle, J.; Auf'mkolk, M.; Rokos, H.; Hesch, R.D.; Cody, V.
Rat liver iodothyronine monodeiodinase. Evaluation of the iodothyronine ligand-binding site
J. Biol. Chem.
261
11613-11622
1986
Rattus norvegicus
Auf'mkolk, M.; Koehrle, J.; Hesch, R.D.; Cody, V.
Inhibition of rat liver iodothyronine deiodinase. Interaction of aurones with the iodothyronine ligand-binding site
J. Biol. Chem.
261
11623-11630
1986
Rattus norvegicus
Leonard, J.L.; Rosenberg, I.N.
Solubilization of a phospholipid-requiring enzyme, iodothyronine 5-deiodinase, from rat kidney membranes
Biochim. Biophys. Acta
659
205-218
1981
Rattus sp.
Colquhoun, E.Q.; Thomson, R.M.
Lysosomal thyroid hormone 5-deiodinase
FEBS Lett.
177
221-226
1984
Rattus sp.
Visser, T.J.
Deiodination of thyroid hormone and the role of glutathione
Trends Biochem. Sci.
5
222-224
1980
Rattus sp.
-
Auf dem Brinke, D.; Hesch, R.D.; Köhrle, J.
Re-examination of the subcellular localization of thyroxine 5-deiodination in rat liver
Biochem. J.
180
273-279
1979
Rattus norvegicus
Ericksen, V.J.; Cavalieri, R.R.; Rosenberg, L.L.
Phenolic and nonphenolic ring iodothyronine deiodinases from rat thyroid gland
Endocrinology
108
1257-1264
1981
Rattus sp.
Leonard, J.L.; Siegrist-Kaiser, C.A.; Zuckerman, C.J.
Regulation of type II iodothyronine 5'-deiodinase by thyroid hormone
J. Biol. Chem.
265
940-946
1990
Rattus sp.
Leonard, D.M.; Stachelek, S.J.; Safran, M.; Farwell, A.P.; Kowalik, T.F.; Leonard, J.L.
Cloning, expression, and functional characterization of the substrate binding subunit of rat type II iodothyroine 5'-deiodinase
J. Biol. Chem.
275
25194-25201
2000
Rattus sp.
Yu, J.; Koenig, R.J.
Regulation of hepatocyte thyroxine 5'-deiodinase by T3 and nuclear receptor coactivators as a model of the sick euthyroid syndrome
J. Biol. Chem.
275
38296-38301
2000
Homo sapiens, Mus musculus, Rattus sp.
Sharifi, J.; St.Germain, D.L.
The cDNA for the type I iodothyroine 5'-deiodinase encodes an enzyme manifesting both high KM and low KM activity
J. Biol. Chem.
267
12539-12544
1992
Rattus sp.
Safran, M.; Leonard, J.L.
Comparison of the physicochemical properties of type I and type II iodothyroine 5'-deiodinase
J. Biol. Chem.
266
3233-3238
1991
Rattus sp.
Berry, M.J.; Kieffer, J.D.; Harney, J.W.; Larsen, P.R.
Selenocysteine confers the biochemical properties charateristic of the type I iodothyronine deiodinase
J. Biol. Chem.
266
14155-14158
1991
Rattus sp.
Garcia-Macias, J.F.; Molinero, P.; Guerrero, J.M.; Osuna, C.
Expression of type II thyroxine 5'-deiodinase from rat harderian gland in Xenopus laevis oocytes
FEBS Lett.
354
110-112
1994
Homo sapiens, Rattus sp.
Orozco, A.; Silva, J.E.; Valverde-R, C.
Rainbow trout liver expresses two iodothyronine phenolic ring deiodinase pathways with the characteristics of mammalian types I and II 5'-deiodinases
Endocrinology
138
254-258
1997
Gallus gallus, Oncorhynchus mykiss, Lithobates catesbeianus, Rattus sp.
Burmeister, L.A.; Pachucki, J.; St.Germain, D.L.
Thyroid hormones inhibit type 2 iodothyronine deiodinase in the rat cerebral cortex by both pre- and posttranslational mechanisms
Endocrinology
138
5231-5237
1997
Rattus sp.
Santini, F.; Chopra, I.J.; Hurd, R.E.; Chua Teco, G.N.
A study of the characteristics of hepatic iodothyronine 5'-monodeiodinase in various vertebrate species
Endocrinology
131
830-834
1992
Bos taurus, Cavia porcellus, Gallus gallus, Ovis aries, Homo sapiens, Mus musculus, Rattus sp., Sus scrofa
Santini, F.; Chopra, I.J.; Hurd, R.E.; Solomon, D.H.; Chua Teco, G.N.
A study of the characteristics of the rat placental iodothyronine 5'-monodeiodinase: evidence that it is distinct from the rat hepatic iodothyronine 5'-monoiodinase
Endocrinology
130
2325-2332
1992
Rattus norvegicus
Mori, Y.; Nishikawa, M.; Toyoda, N.; Yonemoto, T.; Matsubara, H.; Inada, M.
Iodothyronine 5'-deiodinase activity in cultured rat myocardial cells: characteristics and effects of triiodothyronine and angiotensin II
Endocrinology
128
3105-3112
1991
Rattus sp.
Molinero, P.; Osuna, C.; Guerrero, J.M.
Type II thyroxine 5'-deiodinase in the rat thymus
J. Endocrinol.
146
105-111
1995
Rattus sp.
Osuna, C.; Orta, J.M.; Rubio, A.; Molinero, P.; Guerrero, J.M.
Thyroxine type II 5'-deiodinase activity in pineal and harderian glands is enhanced by hypothyroidism but is independent of serum thyroxine concentrations during hyperthyroidism
Int. J. Biochem.
25
1041-1046
1993
Rattus sp.
Goswami, A.; Rosenberg, I.N.
Reconstitution of a purified and partially active low KM iodothyronine 5'-deiodinase with phospholipids
Biochem. Int.
27
257-263
1992
Rattus sp.
Darras, V.M.; Berghman, L.R.; Vanderpooten, A.; Kuhn, E.R.
Growth hormone acutely decreases type III iodothyronine deiodinase in chicken liver
FEBS Lett.
310
5-8
1992
Gallus gallus
Bates, J.M.; Spate, V.L.; Morris, J.S.; St.Germain, D.L.; Galton, V.A.
Effects of selenium deficiency on tissue selenium content, deiodinase activity, and thyroid hormone economy in the rat during development
Endocrinology
141
2490-2500
2000
Rattus norvegicus
Koehrle, J.
Iodothyronine deiodinases
Methods Enzymol.
347
125-167
2002
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus, vertebrata
Steinsapir, J.; Bianco, A.C.; Buettner, C.; Harney, J.; Larsen, P.R.
Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center
Endocrinology
141
1127-1135
2000
Homo sapiens (Q92813), Homo sapiens
Buettner, C.; Harney, J.W.; Larsen, P.R.
The role of selenocysteine 133 in catalysis by the human type 2 iodothyronine deiodinase
Endocrinology
141
4606-4612
2000
Homo sapiens (Q92813), Homo sapiens
Kuiper, G.G.; Klootwijk, W.; Visser, T.J.
Substitution of cysteine for a conserved alanine residue in the catalytic center of type II iodothyronine deiodinase alters interaction with reducing cofactor
Endocrinology
143
1190-1198
2002
Homo sapiens (Q92813), Homo sapiens
Kuiper, G.G.; Wassen, F.; Klootwijk, W.; Van Toor, H.; Kaptein, E.; Visser, T.J.
Molecular basis for the substrate selectivity of cat type I iodothyronine deiodinase
Endocrinology
144
5411-5421
2003
Felis catus
Curcio-Morelli, C.; Gereben, B.; Zavacki, A.M.; Kim, B.W.; Huang, S.; Harney, J.W.; Larsen, P.R.; Bianco, A.C.
In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases
Endocrinology
144
937-946
2003
Homo sapiens (P49895), Homo sapiens (Q92813), Homo sapiens
Shepherdley, C.A.; Richardson, S.J.; Evans, B.K.; Kuehn, E.R.; Darras, V.M.
Characterization of outer ring iodothyronine deiodinases in tissues of the saltwater crocodile (Crocodylus porosus)
Gen. Comp. Endocrinol.
125
387-398
2002
Crocodylus porosus
Brzezinska-Slebodzinska, E.; Slebodzinski, A.B.; Kowalska, K.
Evidence for the presence of 5'-deiodinase in mammalian seminal plasma and for the increase in enzyme activity in the prepubertal testis
Int. J. Androl.
23
218-224
2000
Sus scrofa
Leonard, J.L.; Visser, T.J.; Leonard, D.M.
Characterization of the subunit structure of the catalytically active type I iodothyronine deiodinase
J. Biol. Chem.
276
2600-2607
2001
Rattus norvegicus (P24389)
Curcio, C.; Baqui, M.M.; Salvatore, D.; Rihn, B.H.; Mohr, S.; Harney, J.W.; Larsen, P.R.; Bianco, A.C.
The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line
J. Biol. Chem.
276
30183-30187
2001
Homo sapiens (Q92813), Homo sapiens
Verhoelst, C.H.; Van Der Geyten, S.; Darras, V.M.
Renal and hepatic distribution of type I and type III iodothyronine deiodinase protein in chicken
J. Endocrinol.
181
85-90
2004
Gallus gallus, Gallus gallus (O42411)
Kuiper, G.G.; Klootwijk, W.; Visser, T.J.
Expression of recombinant membrane-bound type I iodothyronine deiodinase in yeast
J. Mol. Endocrinol.
34
865-878
2005
Rattus norvegicus (P24389)
Song, S.; Sorimachi, K.; Adachi, K.; Oka, T.
Biochemical and molecular biological evidence for the presence of type II iodothyronine deiodinase in mouse mammary gland
Mol. Cell. Endocrinol.
160
173-181
2000
Mus musculus (Q9Z1Y9), Mus musculus
Yasuo, S.; Yoshimura, T.; Ebihara, S.; Korf, H.W.
Temporal dynamics of type 2 deiodinase expression after melatonin injections in Syrian hamsters
Endocrinology
148
4385-4392
2007
Mesocricetus auratus
Lamirand, A.; Mercier, G.; Ramauge, M.; Pierre, M.; Courtin, F.
Hypoxia stabilizes type 2 deiodinase activity in rat astrocytes
Endocrinology
148
4745-4753
2007
Rattus norvegicus
Fekete, C.; Freitas, B.C.; Zeoeld, A.; Wittmann, G.; Kadar, A.; Liposits, Z.; Christoffolete, M.A.; Singru, P.; Lechan, R.M.; Bianco, A.C.; Gereben, B.
Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain
Endocrinology
148
4865-4874
2007
Rattus norvegicus
Kanou, Y.; Hishinuma, A.; Tsunekawa, K.; Seki, K.; Mizuno, Y.; Fujisawa, H.; Imai, T.; Miura, Y.; Nagasaka, T.; Yamada, C.; Ieiri, T.; Murakami, M.; Murata, Y.
Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothyronine deiodinase activity
J. Clin. Endocrinol. Metab.
92
1451-1457
2007
Homo sapiens
Araujo, R.L.; de Andrade, B.M.; de Figueiredo, A.S.; da Silva, M.L.; Marassi, M.P.; Pereira, V.d.o.s..S.; Bouskela, E.; Carvalho, D.P.
Low replacement doses of thyroxine during food restriction restores type 1 deiodinase activity in rats and promotes body protein loss
J. Endocrinol.
198
119-125
2008
Rattus norvegicus
Ng, L.; Hernandez, A.; He, W.; Ren, T.; Srinivas, M.; Ma, M.; Galton, V.A.; St Germain, D.L.; Forrest, D.
A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory function
Endocrinology
150
1952-1960
2009
Mus musculus (Q9Z1Y9)
Boelen, A.; Kwakkel, J.; Wieland, C.W.; St Germain, D.L.; Fliers, E.; Hernandez, A.
Impaired bacterial clearance in type 3 deiodinase-deficient mice infected with Streptococcus pneumoniae
Endocrinology
150
1984-1990
2009
Mus musculus (Q61153), Mus musculus (Q9Z148), Mus musculus
Aerts, G.; Arrojo E Drigo, R.; Van Herck, S.L.; Sammels, E.; Mirebeau-Prunier, D.; Gereben, B.; Zeoeld, A.; Harney, J.W.; Huang, S.A.; Mulcahey, M.A.; Van der Geyten, S.; Van den Bergh, G.; Arckens, L.; Darras, V.M.; Zavacki, A.M.
Knockdown of the type 3 iodothyronine deiodinase (D3) interacting protein peroxiredoxin 3 decreases D3-mediated deiodination in intact cells
Endocrinology
150
5171-5180
2009
Homo sapiens (P49895), Homo sapiens (Q92813)
Celi, F.S.; Coppotelli, G.; Chidakel, A.; Kelly, M.; Brillante, B.A.; Shawker, T.; Cherman, N.; Feuillan, P.P.; Collins, M.T.
The role of type 1 and type 2 5-deiodinase in the pathophysiology of the 3,5,3-triiodothyronine toxicosis of McCune-Albright syndrome
J. Clin. Endocrinol. Metab.
93
2383-2389
2008
Homo sapiens
Ohguchi, H.; Tanaka, T.; Uchida, A.; Magoori, K.; Kudo, H.; Kim, I.; Daigo, K.; Sakakibara, I.; Okamura, M.; Harigae, H.; Sasaki, T.; Osborne, T.F.; Gonzalez, F.J.; Hamakubo, T.; Kodama, T.; Sakai, J.
Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9
Mol. Cell. Biol.
28
3917-3931
2008
Mus musculus (Q61153), Mus musculus
Zavacki, A.M.; Arrojo E Drigo, R.; Freitas, B.C.; Chung, M.; Harney, J.W.; Egri, P.; Wittmann, G.; Fekete, C.; Gereben, B.; Bianco, A.C.
The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase
Mol. Cell. Biol.
29
5339-5347
2009
Homo sapiens
Meyer, E.L.; Goemann, I.M.; Dora, J.M.; Wagner, M.S.; Maia, A.L.
Type 2 iodothyronine deiodinase is highly expressed in medullary thyroid carcinoma
Mol. Cell. Endocrinol.
289
16-22
2008
Homo sapiens
Macek Jilkova, Z.; Pavelka, S.; Flachs, P.; Hensler, M.; Kus, V.; Kopecky, J.
Modulation of type I iodothyronine 5-deiodinase activity in white adipose tissue by nutrition: possible involvement of leptin
Physiol. Res.
59
561-569
2010
Mus musculus
Lopez-Juarez, A.; Delgado, G.; Aceves, C.; Anguiano, B.
Type 1 deiodinase activity and generation of triiodothyronine (T3) in prostate of sexually active rats
Prostate
69
1651-1659
2009
Rattus norvegicus
Piekielko-Witkowska, A.; Master, A.; Wojcicka, A.; Boguslawska, J.; Brozda, I.; Tanski, Z.; Nauman, A.
Disturbed expression of type 1 iodothyronine deiodinase splice variants in human renal cancer
Thyroid
19
1105-1113
2009
Homo sapiens (P49895), Homo sapiens
Goto, K.; Sonoda, D.; Shimada, K.; Sase, S.; Kawashima, T.
Modeling of the 5'-deiodination of thyroxine by iodothyronine deiodinase: Chemical corroboration of a selenenyl iodide intermediate
Angew. Chem.
49
545-547
2010
Homo sapiens
Manna, D.; Mugesh, G.
A chemical model for the inner-ring deiodination of thyroxine by iodothyronine deiodinase
Angew. Chem.
49
9246-9249
2010
Homo sapiens
-
Kornasiewicz, O.; Debski, M.; Stepnowska, M.; Sza?as, A.; Bar-Andziak, E.; Krawczyk, M.
The enzymatic activity of type 1 iodothyronine deiodinase (D1) is low in liver hemangioma: a preliminary study
Arch. Immunol. Ther. Exp.
58
77-80
2010
Homo sapiens
Wang, Y.Y.; Morimoto, S.; Du, C.K.; Lu, Q.W.; Zhan, D.Y.; Tsutsumi, T.; Ide, T.; Miwa, Y.; Takahashi-Yanaga, F.; Sasaguri, T.
Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy
Cardiovasc. Res.
87
636-646
2010
Mus musculus
Goemann, I.; Gereben, B.; Harney, J.; Zhu, B.; Maia, A.; Larsen, P.
Substitution of serine for proline in the active center of type 2 iodothyronine deiodinase substantially alters its in vitro biochemical properties with dithiothreitol but not its function in intact cells
Endocrinology
151
821-829
2010
Homo sapiens
Ito, M.; Toyoda, N.; Nomura, E.; Takamura, Y.; Amino, N.; Iwasaka, T.; Takamatsu, J.; Miyauchi, A.; Nishikawa, M.
Type 1 and type 2 iodothyronine deiodinases in the thyroid gland of patients with 3,5,3'-triiodothyronine-predominant Graves' disease
Eur. J. Endocrinol.
164
95-100
2011
Homo sapiens
Dentice, M.; Marsili, A.; Ambrosio, R.; Guardiola, O.; Sibilio, A.; Paik, J.H.; Minchiotti, G.; DePinho, R.A.; Fenzi, G.; Larsen, P.R.; Salvatore, D.
The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration
J. Clin. Invest.
120
4021-4030
2010
Mus musculus
Lamirand, A.; Ramauge, M.; Pierre, M.; Courtin, F.
Bacterial lipopolysaccharide induces type 2 deiodinase in cultured rat astrocytes
J. Endocrinol.
208
183-192
2012
Rattus norvegicus
Pavelka, S.
Radiometric enzyme assays: development of methods for extremely sensitive determination of types 1, 2 and 3 iodothyronine deiodinase enzyme activities
J. Radioanal. Nucl. Chem.
286
861-865
2010
Rattus norvegicus
-
Bassett, J.H.; Boyde, A.; Howell, P.G.; Bassett, R.H.; Galliford, T.M.; Archanco, M.; Evans, H.; Lawson, M.A.; Croucher, P.; St Germain, D.L.; Galton, V.A.; Williams, G.R.
Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts
Proc. Natl. Acad. Sci. USA
107
7604-7609
2010
Mus musculus
Piehl, S.; Heberer, T.; Balizs, G.; Scanlan, T.S.; Kohrle, J.
Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates
Rapid Commun. Mass Spectrom.
22
3286-3296
2008
Homo sapiens, Mus musculus
Ramadan, W.; Marsili, A.; Huang, S.; Larsen, P.R.; Silva, J.E.
Type-2 iodothyronine 5-deiodinase in skeletal muscle of C57BL/6 mice. I. Identity, subcellular localization, and characterization
Endocrinology
152
3082-3092
2011
Mus musculus, Mus musculus C57BL/6
Barca-Mayo, O.; Liao, X.H.; DiCosmo, C.; Dumitrescu, A.; Moreno-Vinasco, L.; Wade, M.S.; Sammani, S.; Mirzapoiazova, T.; Garcia, J.G.; Refetoff, S.; Weiss, R.E.
Role of type 2 deiodinase in response to acute lung injury (ALI) in mice
Proc. Natl. Acad. Sci. USA
108
E1321-E1329
2011
Mus musculus
Louzada, R.A.; Santos, M.C.; Cavalcanti-de-Albuquerque, J.P.; Rangel, I.F.; Ferreira, A.C.; Galina, A.; Werneck-de-Castro, J.P.; Carvalho, D.P.
Type 2 iodothyronine deiodinase is upregulated in rat slow- and fast-twitch skeletal muscle during cold exposure
Am. J. Physiol. Endocrinol. Metab.
307
E1020-E1029
2014
Rattus norvegicus (P70551)
Kornasiewicz, O.; Debski, M.; Grat, M.; Lenartowicz, B.; Stepnowska, M.; Szalas, A.; Bar-Andziak, E.; Krawczyk, M.
Enzymatic activity of type 1 iodothyronine deiodinase in selected liver tumors
Arch. Med. Sci.
10
801-805
2014
Homo sapiens (P49895), Homo sapiens
Aoki, T.; Tsunekawa, K.; Araki, O.; Ogiwara, T.; Nara, M.; Sumino, H.; Kimura, T.; Murakami, M.
Type 2 iodothyronine deiodinase activity is required for rapid stimulation of PI3K by thyroxine in human umbilical vein endothelial cells
Endocrinology
156
4312-4324
2015
Homo sapiens (Q9C0K2), Homo sapiens
Wu, T.; Shi, X.; Zhou, Z.; Wang, L.; Wang, M.; Wang, L.; Huang, M.; Yang, C.; Song, L.
An iodothyronine deiodinase from Chlamys farreri and its induced mRNA expression after LPS stimulation
Fish Shellfish Immunol.
33
286-293
2012
Azumapecten farreri (H6U5U5), Azumapecten farreri
Yamauchi, I.; Sakane, Y.; Yamashita, T.; Hirota, K.; Ueda, Y.; Kanai, Y.; Yamashita, Y.; Kondo, E.; Fujii, T.; Taura, D.; Sone, M.; Yasoda, A.; Inagaki, N.
Effects of growth hormone on thyroid function are mediated by type 2 iodothyronine deiodinase in humans
Endocrine
59
353-363
2018
Homo sapiens
Awad, H.; Alrefaie, Z.
An evidence for the transcriptional regulation of iodothyronine deiodinase 2 by progesterone in ovarectomized rats
J. Physiol. Biochem.
70
331-339
2014
Rattus norvegicus
Poplawski, P.; Rybicka, B.; Boguslawska, J.; Rodzik, K.; Visser, T.J.; Nauman, A.; Piekielko-Witkowska, A.
Induction of type 1 iodothyronine deiodinase expression inhibits proliferation and migration of renal cancer cells
Mol. Cell. Endocrinol.
442
58-67
2017
Homo sapiens
Sakane, Y.; Kanamoto, N.; Yamauchi, I.; Tagami, T.; Morita, Y.; Miura, M.; Sone, M.; Yasoda, A.; Kimura, T.; Nakao, K.; Inagaki, N.
Regulation of type 1 iodothyronine deiodinase by LXRalpha
PLoS ONE
12
e0179213
2017
Homo sapiens
Poplawski, P.; Wisniewski, J.; Rijntjes, E.; Richards, K.; Rybicka, B.; Kohrle, J.; Piekielko-Witkowska, A.
Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system
PLoS ONE
12
e0190179
2017
Homo sapiens
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