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BRENDA support

1.21.99.4: thyroxine 5'-deiodinase

This is an abbreviated version!
For detailed information about thyroxine 5'-deiodinase, go to the full flat file.

Word Map on EC 1.21.99.4

Reaction

3,3',5-triiodo-L-thyronine
+
Iodide
 +
acceptor
 +
H+
=
L-thyroxine
 +
reduced acceptor

Synonyms

5DI , 5DII , 5DIII , D1 5'-deiodinase, D2 5'-deiodinase, deiodinase, diiodothyronine 5'-deiodinase, Dio, DIO1, DIO2, DIOI , DIOII , DIOIII , EC 1.97.1.10, EC 3.8.1.4, ID-1, ID-2, ID-3, iodothyronine 5'-deiodinase, Iodothyronine 5'-monodeiodinase, iodothyronine 5-deiodinase, iodothyronine deiodinase 2, iodothyronine deiodinase D2, iodothyronine inner ring monodeiodinase, iodothyronine outer ring monodeiodinase, L-thyroxine iodohydrolase (reducing), thyroxine 5-deiodinase, Thyroxine deiodinase, type 1 5'-deiodinase, type 1 deiodinase, Type 1 DI , type 1 iodothyronine deiodinase, type 2 5'-deiodinase, type 2 deiodinase, Type 2 DI , type 2 iodothyronine deiodinase, type 3 deiodinase, Type 3 DI , type I iodothyronine 5'-deiodinase, type I iodothyronine deiodinase, type I-like deiodinase, type II iodothyronine deiodinase, type II-like deiodinase, Type-I 5'deiodinase , Type-II 5'deiodinase , Type-III 5'deiodinase , types 1 iodothyronine selenodeiodinase, types 2 iodothyronine selenodeiodinase, XL-15

ECTree

     1 Oxidoreductases
         1.21 Catalysing the reaction X-H + Y-H = X-Y
             1.21.99 With unknown physiological acceptors
                1.21.99.4 thyroxine 5'-deiodinase

Source Tissue

Source Tissue on EC 1.21.99.4 - thyroxine 5'-deiodinase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
hepatocellular carcinoma
Manually annotated by BRENDA team
-
isozyme type I
Manually annotated by BRENDA team
low level of activity
Manually annotated by BRENDA team
low level of activity
Manually annotated by BRENDA team
-
isozyme Dio3
Manually annotated by BRENDA team
after 10 days of cold exposure an increase of 2.8fold in Dio2 activity is detected in white glycolytic gastrocnemius but not in red oxidative gastrocnemius fibers
Manually annotated by BRENDA team
high expression level
Manually annotated by BRENDA team
expression of type 2 iodothyronine deiodinase D2, which converts T4 to T3, and TR1 in HUVECs
Manually annotated by BRENDA team
-
thyronine 5'-deiodinase type II
Manually annotated by BRENDA team
-
thyronine 5'-deiodinase type II
Manually annotated by BRENDA team
low level of activity
Manually annotated by BRENDA team
-
high expression
Manually annotated by BRENDA team
-
the enzyme is restricted to mature primary osteoblasts
Manually annotated by BRENDA team
-
thyroid tissue samples are collected from five patients, three affected by toxic nodule, and from areas of normal thyroid parenchyma from five patients undergoing total thyroidectomy for thyroid cancer
Manually annotated by BRENDA team
low level of activity
Manually annotated by BRENDA team
additional information