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1.21.99.4: thyroxine 5'-deiodinase

This is an abbreviated version!
For detailed information about thyroxine 5'-deiodinase, go to the full flat file.

Word Map on EC 1.21.99.4

Reaction

3,3',5-triiodo-L-thyronine
+
Iodide
 +
acceptor
 +
H+
=
L-thyroxine
 +
reduced acceptor

Synonyms

5DI , 5DII , 5DIII , D1 5'-deiodinase, D2 5'-deiodinase, deiodinase, diiodothyronine 5'-deiodinase, Dio, DIO1, DIO2, DIOI , DIOII , DIOIII , EC 1.97.1.10, EC 3.8.1.4, ID-1, ID-2, ID-3, iodothyronine 5'-deiodinase, Iodothyronine 5'-monodeiodinase, iodothyronine 5-deiodinase, iodothyronine deiodinase 2, iodothyronine deiodinase D2, iodothyronine inner ring monodeiodinase, iodothyronine outer ring monodeiodinase, L-thyroxine iodohydrolase (reducing), thyroxine 5-deiodinase, Thyroxine deiodinase, type 1 5'-deiodinase, type 1 deiodinase, Type 1 DI , type 1 iodothyronine deiodinase, type 2 5'-deiodinase, type 2 deiodinase, Type 2 DI , type 2 iodothyronine deiodinase, type 3 deiodinase, Type 3 DI , type I iodothyronine 5'-deiodinase, type I iodothyronine deiodinase, type I-like deiodinase, type II iodothyronine deiodinase, type II-like deiodinase, Type-I 5'deiodinase , Type-II 5'deiodinase , Type-III 5'deiodinase , types 1 iodothyronine selenodeiodinase, types 2 iodothyronine selenodeiodinase, XL-15

ECTree

     1 Oxidoreductases
         1.21 Catalysing the reaction X-H + Y-H = X-Y
             1.21.99 With unknown physiological acceptors
                1.21.99.4 thyroxine 5'-deiodinase

Specific Activity

Specific Activity on EC 1.21.99.4 - thyroxine 5'-deiodinase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000000003
-
medium alone
0.00000000041
-
medullary thyroid carcinoma
0.00000000043
-
normal thyroid tissue
0.0000000005
pituitary type 2 deiodinase activity, type 3 deiodinase knockout mice after infection with Streptococcus pneumoniae
0.0000000006
-
hypoxia
0.00000000075
pituitary type 2 deiodinase activity, wild-type mice after infection with Streptococcus pneumoniae
0.0000000014
value about, pituitary type 2 deiodinase activity, type 3 deiodinase knockout mice
0.0000000015
value about, pituitary type 2 deiodinase activity, wild-type mice
0.0000000058
-
normal tissues
0.000000013
-
eight weeks high-fat diet, interscapular white fat, 3,3'-diiodothyronine
0.000000015
-
eight weeks low-fat diet, interscapular white fat, 3,3'-diiodothyronine
0.000000025
-
in presence of carbobenzoxy-L-leucyl-L-leucyl-L-leucinal
0.0000000286
-
normal tissues
0.00000003
-
10 micromol forskolin
0.000000033
-
two weeks low-fat diet, interscapular white fat, 3,3'-diiodothyronine
0.000000035
-
two weeks high-fat diet, interscapular white fat, 3,3'-diiodothyronine
0.000000037
-
two weeks low-fat diet, dorsolumbar white fat, 3,3'-diiodothyronine
0.0000000429
-
McCune-Albright syndrome patients
0.0000000543
-
toxic adenoma patient
0.000000058
-
eight weeks low-fat diet, epididymal white fat, 3,3'-diiodothyronine
0.000000063
-
two weeks high-fat diet, dorsolumbar white fat, 3,3'-diiodothyronine
0.0000000714
-
toxic adenoma patient
0.00000009
-
10 micromol forskolin and hypoxia
0.000000093
-
two weeks low-fat diet, epididymal white fat, 3,3'-diiodothyronine
0.0000001
-
two weeks high-fat diet, epididymal white fat, 3,3'-diiodothyronine
0.000000102
-
effect of leptin on iodothyronine 5'-deiodinase activity, control
0.000000108
-
eight weeks low-fat diet, dorsolumbar white fat, 3,3'-diiodothyronine
0.000000165
-
effect of leptin on iodothyronine 5'-deiodinase activity, mice are injected with three doses, 3 mg/kg, leptin for three days
0.0000001857
-
McCune-Albright syndrome patients
0.000000187
-
eight weeks high-fat diet, dorsolumbar white fat, 3,3'-diiodothyronine
0.0000002
-
eight weeks high-fat diet, epididymal white fat, 3,3'-diiodothyronine
0.00000075
type 3 deiodinase knockout mice
0.000001
0.00000125
wild-type mice after infection with Streptococcus pneumoniae
0.000002
wild-type mice
0.0000025
-
patient with mutation in thyroglobulin gene
0.0000146
-
eight weeks low-fat diet, liver, 3,3'-diiodothyronine
0.0000215
-
two weeks low-fat diet, liver, 3,3'-diiodothyronine
0.0000363
-
two weeks high-fat diet, liver, 3,3'-diiodothyronine
0.0000394
-
eight weeks high-fat diet, liver, 3,3'-diiodothyronine
0.0001
0.0002
0.0003
-
isoenzyme type I
0.0004
-
isoenzyme type I
0.002
-
isoenzyme type I
0.2
-
isoenzyme D2 (type II) in cerebral cortex
2
-
isoenzyme D2 (type II) induced in cultured astrocytes
additional information