1.23.1.4: (-)-lariciresinol reductase
This is an abbreviated version!
For detailed information about (-)-lariciresinol reductase, go to the full flat file.
Reaction
Synonyms
(–)-pinoresinol-(–)-lariciresinol reductase, bi-functional pinoresinol/lariciresinol reductase, bifunctional pinoresinol-lariciresinol reductase, bifunctional pinoresinol-lariciresinol reductase 1, LuPLR1, More, pinoresinol lariciresinol reductase, pinoresinol reductase, pinoresinol reductase 1, pinoresinol-lariciresinol reductase, pinoresinol-lariciresinol reductase-1, pinoresinol/lariciresinol reductase, PLR, PLR-Lu1, PLR-Tp1, PLR-Tp2, PLR1, PrR1, SS-pinoresinol-SS-lariciresinol reductase
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General Information
General Information on EC 1.23.1.4 - (-)-lariciresinol reductase
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malfunction
metabolism
physiological function
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RNAi-generated plants exhibit LuPLR1 gene silencing and fail to accumulate secoisolariciresinol diglucoside (SDG). The accumulation of pinoresinol, the substrate of the PLR1 enzyme, in its diglucosylated form (PDG) is increased in transgenic seeds but does not compensate the overall loss of SDG. The monolignol flux is also deviated through the synthesis of 8-5'-linked neolignans dehydrodiconiferyl alcohol glucoside (DCG) and dihydro-dehydrodiconiferyl alcohol glucoside (DDCG)
malfunction
the loss-of-function mutant of PrR1 shows, in addition to elevated levels of pinoresinol, significantly decreased lignin content and a slightly altered lignin structure with lower abundance of cinnamyl alcohol end groups. Stimulated Raman scattering (SRS) microscopy analysis indicates that the lignin content of the prr1-1 loss-of-function mutant is similar to that of wild-type plants in xylem cells, which exhibit a normal phenotype, but is reduced in the fiber cells. The concentration of the lignan, pinoresinol, is 4.8fold higher in the loss-of-function prr1 mutant than in control plants. Impact of loss of function of PrR1 on the cellular distribution of lignin. The PrR1 isozyme mutation alters the expression level of diverse genes, overview
metabolism
pinoresinol is successively converted into lariciresinol and secoisolariciresinol by PrR. Secoisolariciresinol is glycosylated to secoisolariciresinol diglucoside (SDG). PLR has enantiomeric control on the lignan biosynthetic pathway
metabolism
the enzyme is involved in the biosynthetic pathway of secoisolariciresinol diglucoside in Linum usitatissimum, overview. The correlation coefficient between LuPLR1 gene expression and lignan yatein accumulation is as low
metabolism
the pinoresinol-lariciresinol reductase gene, LuPLR1, encoding bifunctional pinoresinol-lariciresinol reductase, is a key gene involved in secoisolariciresinol diglucoside (SDG) biosynthesis, proposed biosynthesis pathway of SDG oligomer, overview
isozyme LuPLR1 catalyzes the biosynthesis of (+)-secoisolariciresinol ((+)-SECO) leading to (+)-secoisolariciresinol diglucoside in seeds
physiological function
pinoresinol reductase (PrR) catalyzes the conversion of the lignan (-)-pinoresinol to (-)-lariciresinol in Arabidopsis thaliana, where it is encoded by two genes, PrR1 and PrR2, that appear to act redundantly. The enzyme is responsible for the synthesis of the major enantiomer (+)-secoisolariciresinol, it is strongly expressed in the seed coats of developing flax seed. Association of the lignan biosynthetic enzyme encoded by PrR1 with secondary cell wall biosynthesis in fiber cells. PrR1 is regulated by the secondary cell wall transcription factors SND1 and MYB46. PrR1 plays a role in lignan biosynthesis in aerial tissue
physiological function
the pinoresinol-lariciresinol reductase gene, LuPLR1, encoding bifunctional pinoresinol-lariciresinol reductase, is a key gene involved in secoisolariciresinol diglucoside (SDG) biosynthesis, responsible for the synthesis of the enantiomer (+)-secoisolariciresinol, spatiotemporal regulation of LuPLR1 gene expression in flaxseed, overview