1.3.1.1: dihydropyrimidine dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about dihydropyrimidine dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.3.1.1

1.3.1.1

thymidine

riboflavin

1.3.1.2

phosphorylase

thymidylate

5-fluorouracil

medicine

2.4.2.4

immunotitration

2.1.1.45

2.7.1.21

monofunctional

12-o-tetradecanoylphorbol-13-acetate

tpa-treated

e-5-2-bromovinyl-2'-deoxyuridine

analysis

Reaction

Synonyms

dehydrogenase, dihydrouracil, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, dihydrouracil dehydrogenase (NAD+), DPD, pyrimidine deaminase/reductase, pyrimidine reductase, RibD, thymine reductase, uracil reductase

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.1 dihydropyrimidine dehydrogenase (NAD+)

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
5	Activating Compound
737	AA Sequence
5	Application
1	CAS Registry Number
1	Cloned(Commentary)
23	Cofactor
1	Crystallization (Commentary)
4	Disease/ Diagnostics
2	Expression
3	General Information
7	Inhibitors
4	kcat/KM [mM/s]
4	KM Value [mM]
4	Localization
5	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
42	Organism
4	Pathway
4	pH Optimum
1	pH Range
2	Protein Variants
3	Purification (Commentary)
2	Reaction
3	Reaction Type
30	Reference
39	Source Tissue
8	Specific Activity [micromol/min/mg]
38	Substrates and Products (Substrate)
2	Subunits
49	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
4	Turnover Number [1/s]

Application

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Application on EC 1.3.1.1 - dihydropyrimidine dehydrogenase (NAD+)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Application Search

analysis

Homo sapiens

high performance liquid chromatography method for quantification of dihydrouracil to uracil ratio in plasma and application in screening for dihydropyrimidine dehydrogenase deficiency in patients treated with 5-fluorouracil. Plasma dihydrouracil to uracil ratio values are highly correlated with the plasma 5-fluorouracil-half-life values and are significantly associated with the toxic side effects, whereas, data set provided from genetic analysis of the coding sequences of the DPD gene are found to be insufficient to explain all the cases of the 5-fluorouracil-related toxicity pattern. Assay is suitable for routine clinical use for dihydropyrimidine dehydrogenase deficiency assessment in patients prior to 5-fluorouracil administration

700571

medicine

3 entries