1.3.1.104: enoyl-[acyl-carrier-protein] reductase (NADPH)
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For detailed information about enoyl-[acyl-carrier-protein] reductase (NADPH), go to the full flat file.
Reaction
Synonyms
enoyl-ACP reductase, enoyl-acyl carrier protein reductase, enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase, ENR, ETR1, FabI, FabL, Fabl2, JamJ, NADPH 2-enoyl Co A reductase, NWMN_0881, YgaA
ECTree
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Crystallization
Crystallization on EC 1.3.1.104 - enoyl-[acyl-carrier-protein] reductase (NADPH)
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both free form and complexed with NADP+ and inhibitor triclosan, to 2.2 and 1.8 A resolution, respectively. The substrate-binding region in the apo-FabL structure is found in the open form. In addition, the beta4-alpha5 and beta5-alpha7 regions, which include the catalytic residues as well as the cofactor binding residues, get collapsed into the pocket. These differences result in a tetrameric arrangement totally different from NADH-dependent isoform FabI
to 2.5 A resolution. Hexagonal space group P622, with unit-cell parameters a = b = 139.56, c = 62.75 A , alpha = beta = 90, gamma = 120°