1.3.1.12: prephenate dehydrogenase
This is an abbreviated version!
For detailed information about prephenate dehydrogenase, go to the full flat file.
Word Map on EC 1.3.1.12
-
1.3.1.12
-
l-tyrosine
-
h-protein
-
arogenate
-
hyperglycinemia
-
nonketotic
-
4-hydroxyphenylpyruvate
-
aminomethyltransferase
-
dahp
-
3-deoxy-d-arabino-heptulosonate
-
cyclohexadienyl
-
7-phosphate
-
dimethylglycine
-
tetrahydrofolate-dependent
-
glycine-cleavage
-
aminomethyl
-
folate-binding
- 1.3.1.12
- l-tyrosine
- h-protein
- arogenate
- hyperglycinemia
-
nonketotic
- 4-hydroxyphenylpyruvate
- aminomethyltransferase
- dahp
-
3-deoxy-d-arabino-heptulosonate
-
cyclohexadienyl
- 7-phosphate
- dimethylglycine
-
tetrahydrofolate-dependent
-
glycine-cleavage
-
aminomethyl
-
folate-binding
Reaction
Synonyms
AceF, AroQ, bifunctional T-protein, chorismate mutase-prephenate dehydratase, chorismate mutase-prephenate dehydrogenase bifunctional enzyme, chorismate mutase-T:prephenate dehydrogenase bifunctional enzyme, Chorismate mutase/prephenate dehydratase, CM-PD, CM-TyrAp, CM/PDT/PDHG, CMPD, dehydrogenase, prephenate, hydroxyphenylpyruvate synthase, PD, PDH, pdhE-1, PDHG, T-protein, TYR1, tyrA, TyrA dehydrogenase, TyrAp
ECTree
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Reference on EC 1.3.1.12 - prephenate dehydrogenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Friedrich, B.; Friedrich, C.G.; Schlegel, H.G.
Purification and properties of chorismate mutase-prephenate dehydratase and prephenate dehydrogenase from Alcaligenes eutrophus
J. Bacteriol.
126
712-722
1976
Cupriavidus necator
Davidson, B.E.; Hudson, G.S.
Chorismate mutase-prephenate dehydrogenase from Escherichia coli
Methods Enzymol.
142
440-450
1987
Escherichia coli
Bode, R.; Melo, C.; Birnbaum, D.
Regulation of chorismate mutase, prephenate dehydrogenase and prephenate dehydratase of Candida maltosa
J. Basic Microbiol.
25
291-298
1985
Candida maltosa
-
Friedrich, C.G.; Friedrich, B.; Schlegel, H.G.
Regulation of Chorismate mutase-prephenate dehydratase and prephenate dehydrogenase from alcaligenes eutrophus
J. Bacteriol.
126
723-732
1976
Cupriavidus necator
Hagino, H.; Nakayama, K.
Regulatory properties of prephenate dehydrogenase and prephenate dehydratase from Corynebacterium glutamicum
Agric. Biol. Chem.
38
2367-2376
1974
Corynebacterium glutamicum
-
Speth, A.R.; Hund, H.K.; Lingens, F.
Terminal phenylalanine and tyrosine biosynthesis of Microtetraspora glauca
Biol. Chem. Hoppe-Seyler
370
591-599
1989
Microtetraspora glauca
Berry, A.; Jensen, R.A.; Hendry, A.T.
Enzymic arrangement and allosteric regulation of the aromatic amino acid pathway in Neisseria gonorrhoeae
Arch. Microbiol.
149
87-94
1987
Neisseria gonorrhoeae
Fischer, R.; Jensen, R.
Prephenate dehydrogenase (monofunctional)
Methods Enzymol.
142
503-507
1987
Cupriavidus necator, Bacillus subtilis, Xanthomonas campestris
Mannhaupt, G.; Stucka, R.; Pilz, U.; Schwarzlose, C.; Feldmann, H.
Characterization of the prephenate dehydrogenase-encoding gene, TYR1, from Saccharomyces cerevisiae
Gene
85
303-311
1989
Saccharomyces cerevisiae
Maruya, A.; O'Connor, M.J.; Backman, K.
Genetic separability of the chorismate mutase and prephenate dehydrogenase components of the Escherichia coli tyrA gene product
J. Bacteriol.
169
4852-4853
1987
Escherichia coli
Berry, A.; Ahmad, S.; Liss, A.; Jensen, R.A.
Enzymological features of aromatic amino acid biosynthesis reflect the phylogeny of mycoplasmas
J. Gen. Microbiol.
133
2147-2154
1987
Acholeplasma laidlawii, Mycoplasmopsis gallinarum, Mycoplasma iowae, Acholeplasma laidlawii JA1
Ahmad, S.; Jensen, R.A.
The prephenate dehydrogenase component of the bifunctional T-protein in enteric bacteria can utilize L-arogenate
FEBS Lett.
216
133-139
1987
Escherichia coli, Klebsiella pneumoniae
Hund, H.K.; Keller, B.; Lingens, F.
Phenylalanine and tyrosine biosynthesis in sporeforming members of the order Actinomycetales
Z. Naturforsch. C
42
387-393
1987
no activity in Actinomycetales
-
Christopherson, R.I.; Morrison, J.F.
Chorismate mutase-prephenate dehydrogenase from Escherichia coli: positive cooperativity with substrates and inhibitors
Biochemistry
24
1116-1121
1985
Escherichia coli
Hudson, G.S.; Wong, V.; Davidson, B.E.
Chorismate mutase/prephenate dehydrogenase from Escherichia coli K12: purification, characterization, and identification of a reactive cysteine
Biochemistry
23
6240-6249
1984
Escherichia coli
Hermes, J.D.; Tipton, P.A.; Fisher, M.A.; O'Leary, M.H.; Morrison, J.F.; Cleland, W.W.
Mechanisms of enzymatic and acid-catalyzed decarboxylations of prephenate
Biochemistry
23
6263-6275
1984
Escherichia coli
Christopherson, R.I.; Heyde, E.; Morrison, J.F.
Chorismate mutase-prephenate dehydrogenase from Escherichia coli: spatial relationship of the mutase and dehydrogenase sites
Biochemistry
22
1650-1656
1983
Escherichia coli
Waldner-Sander, S.; Keller, B.; Keller, E.; Lingens, F.
Zur Biosynthese von Phenylalanin und Tyrosin bei Flavobakterien
Hoppe-Seyler's Z. Physiol. Chem.
364
1467-1473
1983
Novosphingobium capsulatum, Sphingomonas paucimobilis
Hudson, G.S.; Howlett, G.J.; Davidson, B.E.
The binding of tyrosine and NAD+ to chorismate mutase/prephenate dehydrogenase from Escherichia coli K12 and the effects of these ligands on the activity and self-association of the enzyme. Analysis in terms of a model
J. Biol. Chem.
258
3114-3120
1983
Escherichia coli
Bhosale, S.B.; Rood, J.I.; Sneddon, M.K.; Morrison, J.F.
Production of chorismate mutase-prephenate dehydrogenase by a strain of Escherichia coli carrying a multicopy, tyrA plasmid. Isolation and properties of the enzyme
Biochim. Biophys. Acta
717
6-11
1982
Escherichia coli
Sampathkumar, P.; Morrison, J.F.
Chorismate mutase-prephenate dehydrogenase from Escherichia coli. Purification and properties of the bifunctional enzyme
Biochim. Biophys. Acta
702
204-211
1982
Escherichia coli
Sampathkumar, P.; Morrison, J.F.
Chorismate mutase-prephenate dehydrogenase from Escherichia coli. Kinetic mechanism of the prephenate dehydrogenase reaction
Biochim. Biophys. Acta
702
212-219
1982
Escherichia coli
Llewellyn, D.J.; Smith, G.D.
Study of chorismate mutase-prephenate dehydrogenase in crude cell extracts of Escherichia coli
Biochemistry
18
4707-4714
1979
Escherichia coli
-
Fazel, A.M.; Jensen, R.A.
Obligatory biosynthesis of L-tyrosine via the pretyrosine branchlet in coryneform bacteria
J. Bacteriol.
138
805-815
1979
no activity in coryneform bacteria
Smith, G.D.; Roberts, D.V.; Daday, A.
Affinity chromatography and inhibition of chorismate mutase-prephenate dehydrogenase by derivatives of phenylalanine and tyrosine
Biochem. J.
165
121-126
1977
Escherichia coli
Stenmark-Cox, S.; Jensen, R.A.
Prephenate dehydrogenase from Pseudomonas aeruginosa is a regulated component of the channel-shuttle mechanism controlling tyrosine-phenylalanine synthesis
Arch. Biochem. Biophys.
167
540-546
1975
Pseudomonas aeruginosa
Koch, G.L.E.; Shaw, D.C.; Gibson, F.
Studies on the relationship between the active sites of chorismate mutase-prephenate dehydrogenase from Escherichia coli or Aerobacter aerogenes
Biochim. Biophys. Acta
258
719-730
1972
Escherichia coli, Klebsiella aerogenes
Dayan, J.; Sprinson, D.B.
Determination of prephenate dehydrogenase activity
Methods Enzymol.
17A
562-563
1970
Escherichia coli, Salmonella sp.
-
Koch, G.L.E.; Shaw, D.C.; Gibson, F.
The purification and characterisation of chorismate mutase-prephenate dehydrogenase from Escherichia coli K12
Biochim. Biophys. Acta
229
795-804
1971
Escherichia coli
Koch, G.L.E.; Shaw, D.C.; Gibson, F.
Characterisation of the subunits of chorismate mutase-prephenate dehydrogenase from Escherichia coli K12
Biochim. Biophys. Acta
229
805-812
1971
Escherichia coli
Koch, G.L.E.; Shaw, D.C.; Gibson, F.
Studies on the subunit structure of chorismate mutase-prephenate dehydrogenase from Aerobacter aerogenes
Biochim. Biophys. Acta
212
387-395
1970
Klebsiella aerogenes
Koch, G.L.E.; Shaw, D.C.; Gibson, F.
Tyrosine biosynthesis in Aerobacter aerogenes. Purification and properties of chorismate mutase-prephenate dehydrogenase
Biochim. Biophys. Acta
212
375-386
1970
Klebsiella aerogenes
Catheside, D.E.A.
Prephenate dehydrogenase from Neurospora: Feedback activation by phenylalanine
Biochem. Biophys. Res. Commun.
367
651-656
1969
Neurospora sp.
-
Heyde, E.; Morrison, J.F.
Kinetic studies on the reactions catalyzed by chorismate mutase-prephenate dehydrogenase from Aerobacter aerogenes
Biochemistry
17
1573-1580
1978
Klebsiella aerogenes
Heyde, E.
Chorismate mutase-prephenate dehydrogenase from Aerobacter aerogenes: evidence that the two reactions occur at one active site
Biochemistry
18
2766-2775
1979
Klebsiella aerogenes
Hudson, G.S.; Davidson, B.E.
Nucleotide sequence and transcription of the phenylalanine and tyrosine operons of Escherichia coli K12
J. Mol. Biol.
180
1023-1051
1984
Escherichia coli
Patel, N.; Pierson, D.L.; Jensen, R.A.
Dual enzymatic routes to L-tyrosine and L-phenylalanine via pretyrosine in Pseudomonas aeruginosa
J. Biol. Chem.
252
5839-5846
1977
Pseudomonas aeruginosa
Ahmad, S.; Jensen, R.A.
Evolution of the biochemical pathway for aromatic amino acid biosynthesis in Serpens flexibilis in relationship to its phylogenetic position
Arch. Microbiol.
147
8-12
1987
Pseudomonas flexibilis
-
Byng, G.S.; Berry, A.; Jensen, R.A.
Evolution of aromatic biosynthesis and fine-tuned phylogenetic positioning of Azomonas, Azotobacter and rRNA group I pseudomonads
Arch. Microbiol.
144
222-227
1986
Azomonas insignis
-
Champney, W.S.; Jensen, R.A.
The enzymology of prephenate dehydrogenase in Bacillus subtilis
J. Biol. Chem.
245
3763-3770
1970
Bacillus subtilis
Fischer, R.S.; Bonner, C.A.; Boone, D.R.; Jensen, R.A.
Clues from a halophilic methanogen about aromatic amino acid biosynthesis in archaebacteria
Arch. Microbiol.
160
440-446
1993
Methanohalophilus mahii
-
Christendat, D.; Saridakis, V.C.; Turnbull, J.L.
Use of site-directed mutagenesis to identify residues specific for each reaction catalyzed by chorismate mutase-prephenate dehydrogenase from Escherichia coli
Biochemistry
37
15703-15712
1998
Escherichia coli
Christendat, D.; Turnbull, J.L.
Identifying groups Involved in the binding of prephenate to prephenate dehydrogenase from Escherichia coli
Biochemistry
38
4782-4793
1999
Escherichia coli
Kishore, N.; Holden, M.J.; Tewari, Y.B.; Goldberg, R.N.
A thermodynamic investigation of some reactions involving prephenic acid
J. Chem. Thermodyn.
31
211-227
1999
Pantoea agglomerans
-
Christopherson, R.I.
Partial inactivation of chorismate mutase-prephenate dehydrogenase from Escherichia coli in the presence of analogs of chorismate
Int. J. Biochem. Cell Biol.
29
589-594
1997
Escherichia coli
Vincent, S.; Chen, S.; Wilson, D.B.; Ganem, B.
Probing the overlap of chorismate mutase and prephenate dehydrogenase sites in the escherichia coli T-protein: a dehydrogenase-selective inhibitor
Bioorg. Med. Chem. Lett.
12
929-931
2002
Escherichia coli
Chen, S.; Vincent, S.; Wilson, D.B.; Ganem, B.
Mapping of chorismate mutase and prephenate dehydrogenase domains in the Escherichia coli T-protein
Eur. J. Biochem.
270
757-763
2003
Escherichia coli
Luetke-Eversloh, T.; Stephanopoulos, G.
Feedback inhibition of chorismate mutase/prephenate dehydrogenase (TyrA) of Escherichia coli: generation and characterization of tyrosine-insensitive mutants
Appl. Environ. Microbiol.
71
7224-7228
2005
Escherichia coli, Escherichia coli K-12 MG1655
Sun, W.; Singh, S.; Zhang, R.; Turnbull, J.L.; Christendat, D.
Crystal structure of prephenate dehydrogenase from Aquifex aeolicus. Insights into the catalytic mechanism
J. Biol. Chem.
281
12919-12928
2006
Aquifex aeolicus
Xu, S.; Yang, Y.; Jin, R.; Zhang, M.; Wang, H.
Purification and characterization of a functionally active Mycobacterium tuberculosis prephenate dehydrogenase
Protein Expr. Purif.
49
151-158
2006
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Bonvin, J.; Aponte, R.A.; Marcantonio, M.; Singh, S.; Christendat, D.; Turnbull, J.L.
Biochemical characterization of prephenate dehydrogenase from the hyperthermophilic bacterium Aquifex aeolicus
Protein Sci.
15
1417-1432
2006
Aquifex aeolicus
Chavez-Bejar, M.I.; Lara, A.R.; Lopez, H.; Hernandez-Chavez, G.; Martinez, A.; Ramirez, O.T.; Bolivar, F.; Gosset, G.
Metabolic engineering of Escherichia coli for L-tyrosine production by expression of genes coding for the chorismate mutase domain of the native chorismate mutase-prephenate dehydratase and a cyclohexadienyl dehydrogenase from Zymomonas mobilis
Appl. Environ. Microbiol.
74
3284-3290
2008
Zymomonas mobilis
Olson, M.M.; Templeton, L.J.; Suh, W.; Youderian, P.; Sariaslani, F.S.; Gatenby, A.A.; Van Dyk, T.K.
Production of tyrosine from sucrose or glucose achieved by rapid genetic changes to phenylalanine-producing Escherichia coli strains
Appl. Microbiol. Biotechnol.
74
1031-1040
2007
Escherichia coli
Patnaik, R.; Zolandz, R.R.; Green, D.A.; Kraynie, D.F.
L-tyrosine production by recombinant Escherichia coli: fermentation optimization and recovery
Biotechnol. Bioeng.
99
741-752
2008
Escherichia coli
Lim, S.; Springstead, J.R.; Yu, M.; Bartkowski, W.; Schroeder, I.; Monbouquette, H.G.
Characterization of a key trifunctional enzyme for aromatic amino acid biosynthesis in Archaeoglobus fulgidus
Extremophiles
13
191-198
2009
Archaeoglobus fulgidus (O30012), Archaeoglobus fulgidus
Sun, W.; Shahinas, D.; Bonvin, J.; Hou, W.; Kimber, M.S.; Turnbull, J.; Christendat, D.
The crystal structure of Aquifex aeolicus prephenate dehydrogenase reveals the mode of tyrosine inhibition
J. Biol. Chem.
284
13223-13232
2009
Aquifex aeolicus (O67636), Aquifex aeolicus
Chiu, H.J.; Abdubek, P.; Astakhova, T.; Axelrod, H.L.; Carlton, D.; Clayton, T.; Das, D.; Deller, M.C.; Duan, L.; Feuerhelm, J.; Grant, J.C.; Grzechnik, A.; Han, G.W.; Jaroszewski, L.; Jin, K.K.; Klock, H.E.; Knuth, M.W.; Kozbial, P.; Krishna, S.S.; Kumar, A.; Marciano, D.; McMullan, D.; Miller, M.D.; Morse, A.T.
The structure of Haemophilus influenzae prephenate dehydrogenase suggests unique features of bifunctional TyrA enzymes
Acta Crystallogr. Sect. F
66
1317-1325
2010
Haemophilus influenzae (P43902), Haemophilus influenzae, Haemophilus influenzae KW20 (P43902)
Jiang, C.; Yin, B.; Tang, M.; Zhao, G.; He, J.; Shen, P.; Wu, B.
Identification of a metagenome-derived prephenate dehydrogenase gene from an alkaline-polluted soil microorganism
Antonie van Leeuwenhoek
103
1209-1219
2013
uncultured bacterium (J9XQS6)
Ku, H.K.; Do, N.H.; Song, J.S.; Choi, S.; Yeon, S.H.; Shin, M.H.; Kim, K.J.; Park, S.R.; Park, I.Y.; Kim, S.K.; Lee, S.J.
Crystal structure of prephenate dehydrogenase from Streptococcus mutans
Int. J. Biol. Macromol.
49
761-766
2011
Streptococcus mutans (Q8DUW0), Streptococcus mutans, Streptococcus mutans ATCC 700610 (Q8DUW0)
Ku, H.; Park, S.; Yang, I.; Kim, S.
Expression and functional characterization of prephenate dehydrogenase from Streptococcus mutans
Process Biochem.
45
607-612
2010
Streptococcus mutans (Q8DUW0), Streptococcus mutans ATCC 700610 (Q8DUW0)
-
Shlaifer, I.; Quashie, P.K.; Kim, H.Y.; Turnbull, J.L.
Biochemical characterization of TyrA enzymes from Ignicoccus hospitalis and Haemophilus influenzae: A comparative study of the bifunctional and monofunctional dehydrogenase forms
Biochim. Biophys. Acta
1865
312-320
2017
Haemophilus influenzae, Haemophilus influenzae RD KW20
Lopez-Nieves, S.; Pringle, A.; Hiroshi, A.M.
Biochemical characterization of TyrA dehydrogenases from Saccharomyces cerevisiae (Ascomycota) and Pleurotus ostreatus (Basidiomycota)
Arch. Biochem. Biophys.
665
12-19
2019
Saccharomyces cerevisiae, Pleurotus ostreatus (A0A386QX79), Pleurotus ostreatus
Jones, D.D.; Horne, H.J.; Reche, P.A.; Perham, R.N.
Structural determinants of post-translational modification and catalytic specificity for the lipoyl domains of the pyruvate dehydrogenase multienzyme complex of Escherichia coli
J. Mol. Biol.
295
289-306
2000
Escherichia coli (P06959)
Shabalin, I.G.; Gritsunov, A.; Hou, J.; S?awek, J.; Miks, C.D.; Cooper, D.R.; Minor, W.; Christendat, D.
Structural and biochemical analysis of Bacillus anthracis prephenate dehydrogenase reveals an unusual mode of inhibition by tyrosine via the ACT domain
FEBS J.
287
2235-2255
2020
Bacillus anthracis (Q81P63)
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