1.3.1.21: 7-dehydrocholesterol reductase

This is an abbreviated version!
For detailed information about 7-dehydrocholesterol reductase, go to the full flat file.

Reaction

Synonyms

3-hydroxysterol DELTA7-reductase, 3beta-hydroxysterol DELTA7-reductase, 3beta-hydroxysterol-DELTA7-reductase, 7-dehydrocholesterol DELTA7 reductase, 7-dehydrocholesterol DELTA7-reductase, 7-DHC reductase, 7-DHCR, Csa7G447780, DAF-36, DELTA5,7-sterol DELTA7-reductase, Des7, Dhcr7, Dhcr7-AS-1, Dhcr7-AS-2, Dhcr7-AS-4, Dwarf5 protein, DWF5, Neverland, Nvd, reductase, 7-dehydrocholesterol, Sterol delta-7-reductase, sterol DELTA7 reductase, sterol DELTA7-reductase

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.21 7-dehydrocholesterol reductase

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Results	in table
6	Activating Compound
80	AA Sequence
13	Application
1	CAS Registry Number
22	Cloned(Commentary)
35	Cofactor
550	Disease/ Diagnostics
1	Expression
19	General Information
3	General Stability
7	IC50 Value
113	Inhibitors
7	Ki Value [mM]
4	KM Value [mM]
33	Localization
1	Metals/Ions
5	Molecular Weight [Da]
55	Natural Substrates/ Products (Substrates)
209	Organism
13	Pathway
5	pH Optimum
2	Posttranslational Modification
63	Protein Variants
2	Purification (Commentary)
4	Reaction
3	Reaction Type
70	Reference
75	Source Tissue
7	Specific Activity [micromol/min/mg]
123	Substrates and Products (Substrate)
7	Subunits
57	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]

IC50 Value

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IC50 Value on EC 1.3.1.21 - 7-dehydrocholesterol reductase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0006

(+)-pachysamine B

Homo sapiens

-

pH and temperature not specified in the publication

741102

0.0005

2-[2-(4-chlorophenyl)ethyl]-6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline

Homo sapiens

-

whole-cell assay, pH not specified in the publication, temperature not specified in the publication

725672

0.000022

3'-methoxy-4'-hydroxyclomiphene

Homo sapiens

-

pH and temperature not specified in the publication

741102

0.0000023

BM 15.766

Homo sapiens

-

whole-cell assay, pH not specified in the publication, temperature not specified in the publication

725672

0.00015

doxorubicin

Homo sapiens

-

pH and temperature not specified in the publication

741102

0.02

epipachysamine D

Homo sapiens

-

pH and temperature not specified in the publication

741102

0.000012

tamoxifen

Homo sapiens

-

pH and temperature not specified in the publication

741102