1.3.1.22: 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) This is an abbreviated version! For detailed information about 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+), go to the full flat file .
Reaction
a 3-oxo-5alpha-steroid +
NADP+ =
a 3-oxo-DELTA4-steroid +
NADPH +
H+
Synonyms 3-oxosteroid 5alpha-reductase, 3-oxosteroid DELTA4-dehydrogenase, 4-ene-3-oxosteroid 5alpha-reductase, 4-ene-5alpha-reductase, 5 alpha-R2, 5 alpha-reductase type 2, 5-alpha reductase I, 5-alpha reductase II, 5-alpha-reductase type 1, 5-alpha-reductase type 2, 5a-reductase type 1, 5a-reductase type 2, 5A2, 5alpha-R1, 5alpha-R2, 5alpha-reductase 1, 5alpha-reductase II, 5alpha-reductase type 1, 5alpha-reductase type 2, 5alpha-reductase type II, 5alpha-SR2, 5alphaR, 5alphaR type 2, 5alphaR1, 5alphaR2, AtDET2, brainneurosteroidogenic 5x02-reductase 1, cholest-4-en-3-one 5alpha-reductase, cortisone alpha-reductase, cortisone DELTA 4-5alphareductase, DCC71_03205, DELTA4-3-ketosteroid 5alpha-oxidoreductase, DELTA4-3-ketosteroid reductase (5alpha), DELTA4-3-oxosteroid-5 alpha-reductase, DELTA4-5alpha-reductase, DELTA4-steroid 5alpha-reductase (progesterone), EC 1.3.1.30, EC 1.3.1.4, LeDET2, microsomal steroid reductase (5alpha), More, NADPH:DELTA4-3-oxosteroid-5alpha-oxidoreductase, neurosteroidogenic 5alpha-reductase 1, progesterone 5alpha-reductase, reduced nicotinamide adenine dinucleotide phosphate:DELTA4-3-ketosteroid 5alpha-oxidoreductase, reductase, cholestenone 5alpha-, reductase, cortisone DELTA: 4-5alpha-, reductase, progesterone 5alpha-, S5alphaR, SRD5A1, SRD5A2, SRDA1, SRDA2, SRDA3, steroid 5-alpha reductase, steroid 5-alpha-reductase, steroid 5alpha reductase type 2, steroid 5alpha-hydrogenase, steroid 5alpha-reductase, steroid 5alpha-reductase type II, testosterone 5alpha-reductase, testosterone delta4-5alpha-reductase, testosterone delta4-hydrogenase, type 1 5alpha-reductase, type 1 5alphaR, type 1 SR, type 1 steroid 5alpha reductase, type 1 steroid 5alpha-reductase, type 2 5alpha-reductase, type 2 5alphaR, type 2 SR, type 2 steroid 5alpha reductase, type 2 steroid 5alpha-reductase, type II 5alpha-reductase, type-1 5alpha-reductase, type-2 5alpha-reductase
ECTree
Source Tissue
Source Tissue on EC 1.3.1.22 - 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
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adrenal 5alpha-reductase expression is decreased in male withdrawal seizure-prone mice
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from beard and axillary hair and frontal scalp hair
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the enzyme is detected in biopsies of pelvic endometriosis
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both type 1 and type 2 isoenzyme, copy number of mRNA and activity of type 1 isoenzyme is significantly higher than type 2
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external
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anterior
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similar 5alpha-R1 mRNA expression in female and male rats, 5alpha-R2 mRNA expression significantly higher in females than in males
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type 2 isoenzyme
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distribution in brain areas
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testosterone concentrations during postnatal sexual differentiation of the rat Ccentral nervous system, among other sex-dependent factors, influence brain levels of 5alpha-reductase isozymes in adulthood and the pattern of their regulation by androgen hormones
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prefrontal cortex
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somatic
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somatic
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concentrated in caput corpus of epididymis
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cultured
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cultured female and male genital skin fibroblasts
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foreskin, Hs68
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not in young laeves, low activity
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higher levels
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only isozyme 5alpha-R1
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prostate cancer cell line
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prostate-specific
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benign prostatic hyperplasia tissue, BPH
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isozymes 5alphaR-1 and 5alphaR-2, only isozyme 5alphaR-1 is found in case of prostate cancer
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prostate carcinoma DU145 cells or from benign prostatic hyperplasia patients, BPH
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from gonadectomized male hamster
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homogenate of
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prostate carcinoma DU145 cells or from BPH patients
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tissues with benign prostatic hyperplasia, primary prostate cancer, prostatic intraepithelial neoplasia, primary prostate cancer treated with neoadjuvant androgen ablation, locally recurrent prostate cancer specimens, and prostate cancer metastases
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390655 , 390656 , 390657 , 396217 , 396219 , 656681 , 675475 , 686575 , 688684 , 688718 , 688719 , 689849 brenda
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hyperplastic
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studies in DU 145 cells, a human cell-line of low androgen sensitivity derived from a cerebral metastasis of an ephithelial prostate cancer
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type-2 5alpha-reductase is only found in prostate and other genital tissues, enhancement of type-1 5alpha-reductase is enhanced in prostate cancer
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ventral
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ventral prostate, activity of both isoform I and II is increased after treatment with oxytocin
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culture, light grown
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female breast skin
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isozymes 5alphaR-1 and 5alphaR-2, dihydrotestosterone overproduction in skin pathologies, overview
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24-26 day old animals, no enzyme activity of isoform II
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decrease in isoenzyme 1 activity and mRNA during testosterone treatment, but not isoenzyme 2. Active immunisation of animals against gonadotrophin-releasing hormone, increase in activity of both isoenzymes
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postnatal animals, enzyme activity is low in 10-day old testis, peaks between days 20 and 40 during puberty and then declines
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additional information
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preembryogenic mass
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additional information
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isozymes show different tissue distribution in androgen target organs
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additional information
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highest activity in organs of acessory reproduction and in liver
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additional information
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not expressed in muscle or bone
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