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1.3.1.24: biliverdin reductase

This is an abbreviated version!
For detailed information about biliverdin reductase, go to the full flat file.

Word Map on EC 1.3.1.24

Reaction

bilirubin
+
NAD(P)+
=
Biliverdin
+
NAD(P)H
+
H+

Synonyms

biliverdin IXalpha reductase, biliverdin IXbeta reductase, biliverdin reductase, biliverdin reductase A, biliverdin reductase B, Biliverdin reductase-A, biliverdin-IXalpha reductase, BLVR subtype B, BLVRA, BLVRB, BV reductase, BVR, BVR-A, BVR-B, BVRA, BVRB, F-BVR, F420H2-dependent biliverdin reductase, hBVR, hBVR-A, reductase, biliverdin, Rv2074, slr1784

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.24 biliverdin reductase

Expression

Expression on EC 1.3.1.24 - biliverdin reductase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
about 56% of the BVR expression in total lung tissue is increased by hypoxia
-
atorvastatin significantly increases BVR-A protein levels, phosphorylation and activity only in parietal cortex
-
bacterial endotoxin, lipopolysaccharide, initiates an inflammatory response in macrophages coming along with a rapid increase in BVR surface expression
BVR expression is unaffected by heat shock
-
BVR is induced by lipopolysaccharides and bromobenzene at a post-transcriptional level
-
doxycycline dose-dependently induces BVR gene expression at the level of mRNA as well as a protein, and BVR activity in genetically modified NIH 3T3 fibroblasts
enzyme expression is up-regulated in breast cancer cells
-
expression is up-regulated in breast, lung, and liver cancers, but not ovarian cancer
hypoxia positively regulates hBVR promoter
-
in fetal liver and maternal liver and placenta ursodeoxycholic acid up-regulates biliverdin-IX reductase
-
in HEK-293A cells, hypoxia modestly increases BVR mRNA levels
-
in HepG2 and JAr cells taurocholic acid and ursodeoxycholic acid up-regulate biliverdin-IX reductase
increased expression in macrophages of primary spontaneous pneumothorax of smokers compared to non-smokers
-
increased levels of heme oxygenase-1 and biliverdin reductase protein in the choroid plexus over the entire period following subarachnoid hemorrhage induction
induction of BVR and HO-2 is mediated by the cAMP-PKA pathway and isoproterenol, overview
-
induction of BVR and HO-2 is mediated by the cAMP-PKA pathway and isoproterenol, overview. The beta-adrenergic antagonist propranolol only slightly induces BVR expression in HEK-293A cells
-
overexpression of IkappaB increases hBVR mRNA
-
oxidative stress induces HO-1, BVR and H-ferritin in lung macrophages, this is involved in development of primary spontaneous pneumothorax disease, overview. HIF-1alpha siRNA transfection completely abrogated the increased HO-1, BVR and H-ferritin mRNA levels
-
patients with chronic hepatitis C virus infection show significantly upregulated enzyme expression in peripheral blood leukocytes
the transcript and protein levels are increased in human tumors and the infiltrating T-cells, monocytes and circulating lymphocytes, as well as the circulating and infiltrating macrophages
-
TNF-alpha negatively regulates hBVR promoter
-
treatment of cultured TALH or IMCD-3 cells with BVR siRNA, 50 or 100 nM, results in an 80% decrease in the level of BVR protein
-
up-regulated in levels of protein and mRNA by hypoxia in pulmonary arterial smooth muscle cell
-
up-regulation is found in the hippocampus of subjects with Alzheimer disease in its earliest form
-