1.3.1.3: DELTA4-3-oxosteroid 5beta-reductase

This is an abbreviated version!
For detailed information about DELTA4-3-oxosteroid 5beta-reductase, go to the full flat file.

Reaction

Synonyms

3-oxo-DELTA4-steroid 5beta-reductase, 4,5beta-dihydrocortisone:NADP+ DELTA4-oxidoreductase, 5-beta-reductase, 5beta-POR, 5beta-red, AKR1D1, AKR1D4, aldo-keto reductase, aldo-keto reductase 1D1, aldo�keto reductase 1D1, androstenedione 5beta-reductase, CARUB_v10005016mg, cortisone 5beta-reductase, cortisone beta-reductase, DELTA 4-5beta-reductase, DELTA4-3-ketosteroid 5beta-reductase, DELTA4-3-oxosteroid 5beta-reductase, DELTA4-hydrogenase, EC 1.3.1.23, EC 1.3.1.3, h5beta-red, h5beta-reductase, More, P5betaR, progesterone 5beta-reductase, reductase, cholestenone 5beta.-, reductase, cortisone DELTA4-5beta-, SRD5beta, St5betaR1, steroid 5beta-reductase, steroid 5beta.-reductase, testosterone 5-beta-reductase, testosterone 5beta-reductase

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.3 DELTA4-3-oxosteroid 5beta-reductase

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Results	in table
37	AA Sequence
5	Application
2	CAS Registry Number
20	Cloned(Commentary)
27	Cofactor
9	Crystallization (Commentary)
96	Disease/ Diagnostics
6	Expression
11	General Information
4	General Stability
30	Inhibitors
43	kcat/KM [mM/s]
5	Ki Value [mM]
78	KM Value [mM]
9	Localization
7	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
45	Organism
6	Pathway
34	PDB ID
14	pH Optimum
3	pH Range
1	pH Stability
1	pI Value
49	Protein Variants
18	Purification (Commentary)
6	Reaction
6	Reaction Type
43	Reference
29	Source Tissue
10	Specific Activity [micromol/min/mg]
4	Storage Stability
123	Substrates and Products (Substrate)
7	Subunits
67	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
53	Turnover Number [1/s]

Expression

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Expression on EC 1.3.1.3 - DELTA4-3-oxosteroid 5beta-reductase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

chenodeoxycholic acid markedly represses AKR1D1 expression in vitro in human hepatoma Hep-G2 cells, regulation occurs through the mitogen-activated protein kinases/c-Jun Nterminal kinases (MAPK/JNK) signaling pathway

Homo sapiens

P51857

763613

chenodeoxycholic acid markedly represses AKR1D1 expression, regulation occurs through the mitogen-activated protein kinases/c-Jun Nterminal kinases (MAPK/JNK) signaling pathway

Mus musculus

Q8VCX1

763613

cholic acid significantly upregulates AKR1D1 expression in HepG2 cells, regulation occurs through the mitogen-activated protein kinases/c-Jun Nterminal kinases (MAPK/JNK) signaling pathway

Homo sapiens

P51857

763613

cholic acid significantly upregulates AKR1D1 expression, regulation occurs through the mitogen-activated protein kinases/c-Jun Nterminal kinases (MAPK/JNK) signaling pathway

Mus musculus

Q8VCX1

763613

presence of chenodeoxycholic acid reduces transcript abundance in H4iiE cell and promoter activity in HepG2 cells

Rattus norvegicus

-

725633

treatment of cells with proteasomal inhibitor, MG-132 increases expression of splice variants AKR1D1-001 and AKR1D1-006

Homo sapiens

P51857

763367