1.3.1.38: trans-2-enoyl-CoA reductase (NADPH)

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For detailed information about trans-2-enoyl-CoA reductase (NADPH), go to the full flat file.

Word Map on EC 1.3.1.38

1.3.1.38

beta-ketoacyl-coa

beta-hydroxyacyl-coa

dehydrase

palmitoyl-coa

butyryl-coa

condensing

vlcfas

nadph-specific

Reaction

Synonyms

2-trans enoyl-ACP(CoA) reductase, ECR, EgTER1, enoyl reductase, InhA, MECR, MECR-1, mitochondrial 2-trans-enoyl-CoA/ACP reductase, mitochondrial 2-trans-enoyl-thioester reductase, NADPH-dependent trans-2-enoyl-CoA reductase, reductase, trans-enoyl coenzyme A, TER, trans-2-enoyl-CoA reductase, trans-2-enoyl-CoA reductase (NADPH)

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)

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Results	in table
1	Activating Compound
138	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
18	Cofactor
5	Disease/ Diagnostics
2	Expression
5	General Information
1	General Stability
20	Inhibitors
6	Ki Value [mM]
16	KM Value [mM]
19	Localization
5	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
30	Organism
5	Pathway
18	PDB ID
2	pH Optimum
1	pH Range
1	pH Stability
17	Protein Variants
5	Purification (Commentary)
4	Reaction
4	Reaction Type
29	Reference
43	Source Tissue
10	Specific Activity [micromol/min/mg]
3	Storage Stability
46	Substrates and Products (Substrate)
5	Subunits
23	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
3	Temperature Stability [°C]
2	Turnover Number [1/s]

Engineering

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Engineering on EC 1.3.1.38 - trans-2-enoyl-CoA reductase (NADPH)

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G225A

Gossypium hirsutum

A9XUG7, A9XUG8

upon expression in Saccharomyces cerevisiae tsc13DELTA mutant significant accumulation of fatty acids C22:0, C20:0, C18:0, C18-OH, and especially C16-OH is detected

G227A

similar to wild-type

G228A

similar to wild-type

G234A

upon expression in Saccharomyces cerevisiae tsc13DELTA mutant significant accumulation of fatty acids C22:0, C20:0, C18:0, C18-OH, and especially C16-OH is detected

699263

I231A

Gossypium hirsutum

A9XUG7, A9XUG8

upon expression in Saccharomyces cerevisiae tsc13DELTA mutant significant accumulation of fatty acids C22:0, C20:0, C18:0, C18-OH, and especially C16-OH is detected

699263

P232A

Gossypium hirsutum

A9XUG7, A9XUG8

upon expression in Saccharomyces cerevisiae tsc13DELTA mutant significant accumulation of fatty acids C22:0, C20:0, C18:0, C18-OH, and especially C16-OH is detected

Q230A

similar to wild-type

R233A

similar to wild-type

S226A

similar to wild-type

Y229A

similar to wild-type

P182L

the mutant exhibits lower trans-2-enoyl-CoA reductase activity as compared with the wild type enzyme

740717

F149A

Mycobacterium tuberculosis

the mutant is not able to optimally position the cofactor for hydride transfer, which correlates with the 30fold decrease in kcat

687289

K165A

Mycobacterium tuberculosis

normal expression in Escherichia coli

657270

K165Q

Mycobacterium tuberculosis

normal expression in Escherichia coli

657270

Y158F

Mycobacterium tuberculosis

expression in Escherichia coli sub-population BL21(DE3)NH

657270

additional information

6 entries