1.3.1.48: 13,14-dehydro-15-oxoprostaglandin 13-reductase

This is an abbreviated version!
For detailed information about 13,14-dehydro-15-oxoprostaglandin 13-reductase, go to the full flat file.

Reaction

Synonyms

15-hydroxyprostaglandin dehydrogenase, 15-keto-PG reductase, 15-ketoprostaglandin DELTA-13-reductase, 15-ketoprostaglandin DELTA13-reductase, 15-ketoprostaglandinDELTA13-reductase, 15-oxoprostaglandin 13-oxidase, 15-oxoprostaglandin 13-reductase, 15-oxoprostaglandin DELTA13-reductase, 15-oxoprostaglandin-DELTA13-reductase, 15-PGDH, Ad-PGR, bifunctional leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, bifunctional LTB4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, DELTA13-15-ketoprostaglandin reductase, leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase, leukotriene B4 dehydrogenase, leukotriene B4-12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, LTB4 12-HD/PGR, LTBDH/PGR, NAD(P)H-dependent alkenal/one oxidoreductase, PG reductase, PGR, PGR-2, PGR1, prostaglandin 13-reductase, prostaglandin DELTA13-reductase, prostaglandin reductase 1, reductase, 15-oxo-DELTA13-prostaglandin

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.48 13,14-dehydro-15-oxoprostaglandin 13-reductase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
2927	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
21	Cofactor
3	Crystallization (Commentary)
35	Disease/ Diagnostics
3	General Information
22	IC50 Value
55	Inhibitors
5	Ki Value [mM]
72	KM Value [mM]
3	Localization
1	Metals/Ions
9	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
21	Organism
6	Pathway
22	PDB ID
3	pH Optimum
2	pH Range
13	Purification (Commentary)
1	Reaction
4	Reaction Type
21	Reference
31	Source Tissue
22	Specific Activity [micromol/min/mg]
8	Storage Stability
123	Substrates and Products (Substrate)
3	Subunits
31	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
28	Turnover Number [1/s]

Disease

topprint

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Disease on EC 1.3.1.48 - 13,14-dehydro-15-oxoprostaglandin 13-reductase

Please use the Disease Search for a specific query.

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Adenoviridae Infections

Restoration of leukotriene B(4)-12-hydroxydehydrogenase/15- oxo-prostaglandin 13-reductase (LTBDH/PGR) expression inhibits lung cancer growth in vitro and in vivo.

19595472

Breast Neoplasms

Auranofin/Vitamin C: A Novel Drug Combination Targeting Triple-Negative Breast Cancer.

30462268, 30779852

Carcinoma

Effect of prostaglandin reductase 1 (PTGR1) on gastric carcinoma using lentivirus-mediated system [Retraction].

29874340

Carcinoma

Effect of prostaglandin reductase 1 (PTGR1) on gastric carcinoma using lentivirus-mediated system.

26823768

Carcinoma, Hepatocellular

Increased expression of prostaglandin reductase 1 in hepatocellular carcinomas from clinical cases and experimental tumors in rats.

24853774

Lung Neoplasms

Restoration of leukotriene B(4)-12-hydroxydehydrogenase/15- oxo-prostaglandin 13-reductase (LTBDH/PGR) expression inhibits lung cancer growth in vitro and in vivo.

19595472

Lung Neoplasms

The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells.

28117410

Neoplasms

Increased expression of prostaglandin reductase 1 in hepatocellular carcinomas from clinical cases and experimental tumors in rats.

24853774

Neoplasms

Prostaglandin Reductase 1 as a Potential Therapeutic Target for Cancer Therapy.

34421612

Obstetric Labor, Premature

Prostanoid concentrations in maternal/fetal plasma and amniotic fluid and intrauterine tissue prostanoid output in relation to myometrial contractility during the onset of adrenocorticotropin-induced preterm labor in sheep.

3855257

Prostatic Neoplasms

Knockdown of prostaglandin reductase 1 (PTGR1) suppresses prostate cancer cell proliferation by inducing cell cycle arrest and apoptosis.

27150108

html completed