1.3.1.56: cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
This is an abbreviated version!
For detailed information about cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase, go to the full flat file.
Word Map on EC 1.3.1.56
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1.3.1.56
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biphenyls
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dioxygenase
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polychlorinated
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testosteroni
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comamonas
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pnomenusa
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burkholderia
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pandoraea
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chlorinated
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chlorobiphenyls
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congener
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dehydrogenation
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toluene
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bpha1a2a3a4
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cis-dihydrodiols
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cepacia
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meta-cleavage
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dehydrogenases
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ortho-substituted
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putida
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2,2\',5,5\'-tetrachlorobiphenyl
- 1.3.1.56
- biphenyls
- dioxygenase
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polychlorinated
- testosteroni
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comamonas
- pnomenusa
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burkholderia
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pandoraea
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chlorinated
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chlorobiphenyls
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congener
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dehydrogenation
- toluene
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bpha1a2a3a4
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cis-dihydrodiols
- cepacia
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meta-cleavage
- dehydrogenases
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ortho-substituted
- putida
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2,2\',5,5\'-tetrachlorobiphenyl
Reaction
Synonyms
2,3-dihydro-2,3-dehydroxybiphenyl-2,3-dehydrogenase, 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase, 2,3-dihydroxy-4-phenylhexa-4,6-diene dehydrogenase, B2,3D, BephB, biphenyl dehydrogenase, biphenyl dihydrodiol dehydrogenase, Biphenyl-2,3-dihydro-2,3-diol dehydrogenase, biphenyl-2,3-dihydrodiol 2,3-dehydrogenase, biphenyl-2,3-dihydrodiol-2,3-dehydrogenase, Biphenyl-cis-diol dehydrogenase, BphB, BphBB-356, BphBB356, cis-2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase, cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase, More, NAD-dependent cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
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General Information
General Information on EC 1.3.1.56 - cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
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evolution
metabolism
physiological function
additional information
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PbBphB is a member of the short-chain dehydrogenase/reductase (SRD) family
evolution
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PbBphB is a member of the short-chain dehydrogenase/reductase (SRD) family
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NAD-dependent cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase (BphB) catalyzes the second step of the PCB catabolic pathway in bacteria
metabolism
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NAD-dependent cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase (BphB) catalyzes the second step of the PCB catabolic pathway in bacteria
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the enzyme is involved in the aerobic biodegradation of polychlorinated biphenyls
physiological function
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the enzyme is the key enzyme in the biphenyl/polychlorinated biphenyl catabolic pathway
physiological function
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the enzyme is the key enzyme in the biphenyl/polychlorinated biphenyl catabolic pathway
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the pocket between strand beta6 and helix alpha8 is the substrate-binding region and corresponds to a disordered region (Leu199-Ser206) in the structures of the apo and binary forms, dynamic behavior of the substrate binding loop. In the holo form, BPY stabilizes the conformation of the binding loop by interacting through the aromatic rings of reaction product 2,3-dihydroxybiphenyl with Val207 and Pro208 residues. Ile204 makes a hydrophobic interaction with the NAD+ cofactor only in the holo simulation. The lack of the latter interaction in the apo and in the binary forms explains the extended mobility of this region in the other two binding states of the protein
additional information
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the pocket between strand beta6 and helix alpha8 is the substrate-binding region and corresponds to a disordered region (Leu199-Ser206) in the structures of the apo and binary forms, dynamic behavior of the substrate binding loop. In the holo form, BPY stabilizes the conformation of the binding loop by interacting through the aromatic rings of reaction product 2,3-dihydroxybiphenyl with Val207 and Pro208 residues. Ile204 makes a hydrophobic interaction with the NAD+ cofactor only in the holo simulation. The lack of the latter interaction in the apo and in the binary forms explains the extended mobility of this region in the other two binding states of the protein
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