1.3.1.70: DELTA14-sterol reductase

This is an abbreviated version!
For detailed information about DELTA14-sterol reductase, go to the full flat file.

Reaction

Synonyms

14-dehydrocholesterol reductase, 14-reductase, 14-SR, 3 beta-hydroxysterol-DELTA14-reductase, 3beta-hydroxysterol DELTA14-reductase, C-14 reductase, C-14 sterol reductase, C14-SR, C14-sterol reductase, C14SR, DELTA14-reductase, DELTA14-SR, DELTA14SR, DELTA7,14-steroid 14-reductase, DELTA7,14-sterol 14-reductase, DELTA7,14-sterol DELTA14-reductase, DELTA7,14-sterol-14-reductase, DELTA8,14-hydroxy steroid DELTA14(15)-reductase, DELTA8,14-steroid 14-reductase, DELTA8,14-sterol 14-reductase, DELTA8,14-sterol DELTA14-reductase, DELTA8,14-sterol-14-reductase, DHCR14, ERG 24, ERG24, erg24-1, erg24A, erg24B, fackel, FACKEL protein, FgERG24A, FgERG24B, FK, fk-J3158, integral membrane sterol reductase, lamin B receptor, lamin-B receptor, LBR, MaSR1, reductase, DELTA8,14-hydroxy steroid DELTA14(15)-, SR-1, sterol 14-reductase, sterol C-14 reductase, sterol C14-reductase, sterol DELTA14,15-reductase, sterol DELTA14-reductase, TM7SF2

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.70 DELTA14-sterol reductase

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Results	in table
10	Activating Compound
966	AA Sequence
3	Application
1	CAS Registry Number
16	Cloned(Commentary)
25	Cofactor
1	Crystallization (Commentary)
92	Disease/ Diagnostics
8	Expression
20	General Information
7	General Stability
12	IC50 Value
82	Inhibitors
16	KM Value [mM]
35	Localization
1	Metals/Ions
6	Molecular Weight [Da]
44	Natural Substrates/ Products (Substrates)
40	Organism
15	Pathway
2	PDB ID
6	pH Optimum
6	pH Range
61	Protein Variants
7	Purification (Commentary)
10	Reaction
3	Reaction Type
36	Reference
64	Source Tissue
2	Specific Activity [micromol/min/mg]
2	Storage Stability
100	Substrates and Products (Substrate)
6	Subunits
90	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]

Engineering

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of the Enzyme Summary Page.

Engineering on EC 1.3.1.70 - DELTA14-sterol reductase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

D363A

Methylotuvimicrobium alcaliphilum

G4SW86

site-directed mutagenesis, inactive mutant

745882

I151M

Methylotuvimicrobium alcaliphilum

G4SW86

site-directed mutagenesis, inactive mutant

745882

K406A

Methylotuvimicrobium alcaliphilum

G4SW86

site-directed mutagenesis, inactive mutant

745882

L304M

Methylotuvimicrobium alcaliphilum

G4SW86

site-directed mutagenesis, inactive mutant

745882

N359A

Methylotuvimicrobium alcaliphilum

G4SW86

site-directed mutagenesis, inactive mutant

745882

R395A

Methylotuvimicrobium alcaliphilum

G4SW86

site-directed mutagenesis, inactive mutant

745882

W352A

Methylotuvimicrobium alcaliphilum

G4SW86

site-directed mutagenesis, inactive mutant

745882

Y241F

Methylotuvimicrobium alcaliphilum

G4SW86

site-directed mutagenesis, inactive mutant

745882

Y360A

Methylotuvimicrobium alcaliphilum

G4SW86

site-directed mutagenesis, inactive mutant

745882

Y407A

Methylotuvimicrobium alcaliphilum

G4SW86

site-directed mutagenesis, inactive mutant

745882

Y414A

Methylotuvimicrobium alcaliphilum

G4SW86

site-directed mutagenesis, inactive mutant

745882

D363A

Methylotuvimicrobium alcaliphilum 20Z

-

site-directed mutagenesis, inactive mutant

-

N359A

Methylotuvimicrobium alcaliphilum 20Z

-

site-directed mutagenesis, inactive mutant

-

W352A

Methylotuvimicrobium alcaliphilum 20Z

-

site-directed mutagenesis, inactive mutant

-

Y407A

Methylotuvimicrobium alcaliphilum 20Z

-

site-directed mutagenesis, inactive mutant

-

Y414A

Methylotuvimicrobium alcaliphilum 20Z

-

site-directed mutagenesis, inactive mutant

-

D207N

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

D227N

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

D276N

Neurospora crassa

-

site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a

656798

D289E

Neurospora crassa

-

site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a

656798

D289N

Neurospora crassa

-

site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a

656798

D293N

Neurospora crassa

-

site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a

656798

D394N

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

D462N

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

D463N

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

E22Q

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

E233D

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

E233Q

Neurospora crassa

-

site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a

656798

E475Q

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656304, 656798

G225C

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656304

H388A

Neurospora crassa

-

site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a

656798

H457A

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

K229A

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

K351A

Neurospora crassa

-

site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a

656798

K351R

Neurospora crassa

-

site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a

656798

K469A

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

R212A

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

R217A

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

R235A

Neurospora crassa

-

site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a

656798

R235K

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

R345A

Neurospora crassa

-

site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a

656798

R355A

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

R458A

Neurospora crassa

-

site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a

656798

R458K

Neurospora crassa

-

site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a

656798

R461A

Neurospora crassa

-

site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a

656798

R461K

Neurospora crassa

-

site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a

656798

T371A

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

Y124F

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

Y273F

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

Y317F

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656304

Y391F

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

Y445F

Neurospora crassa

-

site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a

656798

Y447F

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

Y470F

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

Y477F

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

Y490F

Neurospora crassa

-

site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a

656798

additional information

6 entries

additional information

Arabidopsis thaliana

-

mutational blockage of the enzyme leads to accumulation of atypical products from substrate 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol in vivo, i.e. 5alpha-cholesta-8,14-dien-3beta-ol, (24R)-5alpha-ergosta-8,14-dien-3beta-ol, and (24R)-5alpha-stigmasta-8,14-dien-3beta-ol

657046

additional information

Candida albicans

-

erg24 gene disruption mutant strains, i.e. strain NJ25, NJ50, NJ51, and NJ55, show growth, but altered phenotypes, e.g. increased sensitivity against an allylamine antifungal compound, overview

654204

additional information

Homo sapiens

O76062

enzyme deficiency due to mutations in the lamin B receptor gene causes autosomal recessive HEM/Greenberg skeletal dysplasia

654166

additional information

Homo sapiens

Q14739

enzyme deficiency due to mutations in the lamin B receptor gene causes autosomal recessive HEM/Greenberg skeletal dysplasia

654166

additional information

Homo sapiens

-

enzyme deficiency due to mutations in the lamin B receptor gene causes autosomal recessive HEM/Greenberg skeletal dysplasia

654166

additional information

Mus musculus

Q71KT5

generation of gene Tm7sf2 knockout mice

744648