1.3.1.8: acyl-CoA dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about acyl-CoA dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.3.1.8

1.3.1.8

enoyl-coas

acyl-coas

crotonyl-coa

very-long-chain

vlcfas

butyryl-coa

dehydrase

3-hydroxyacyl-coa

beta-hydroxyacyl-coa

decanoyl-coa

acetyl-coa-dependent

octanoyl-coa

elongase

leek

nadph-specific

collinus

trans-enoyl-coas

synthesis

biotechnology

Reaction

Synonyms

2-enoyl-CoA reductase, 2-trans enoyl-CoA reductase, 2-trans-enoyl-CoA reductase, acyl coenzyme A dehydrogenase (nicotinamide adenine dinucleotide phosphate), CCR, crotonyl CoA reductase, crotonyl coenzyme A reductase, crotonyl-CoA reductase, crotonyl-coenzyme A reductase, dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate), enoyl coenzyme A reductase, enoyl-CoA reductase, MCAD, medium-chain acyl-CoA dehydrogenase, NADPH:enoyl-CoA oxidoreductase, NbECR, RCCR, trans-2-enoyl-CoA reductase

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.8 acyl-CoA dehydrogenase (NADP+)

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
3	Activating Compound
15	AA Sequence
2	Application
1	CAS Registry Number
3	Cloned(Commentary)
33	Cofactor
1	Crystallization (Commentary)
1	General Stability
31	Inhibitors
4	Ki Value [mM]
18	KM Value [mM]
20	Localization
9	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
32	Organism
1	Oxidation Stability
5	Pathway
4	PDB ID
8	pH Optimum
1	pH Range
1	Protein Variants
10	Purification (Commentary)
2	Reaction
4	Reaction Type
30	Reference
26	Source Tissue
18	Specific Activity [micromol/min/mg]
3	Storage Stability
102	Substrates and Products (Substrate)
3	Subunits
22	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]

Reference

top print

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Reference on EC 1.3.1.8 - acyl-CoA dehydrogenase (NADP+)

Please use the Reference Search for a specific query.

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

390751

Bernert, J.T.; Sprecher, H.

An analysis of partial reactions in the overall chain elongation of saturated and unsaturated fatty acids by rat liver microsomes

J. Biol. Chem.

252

6736-6744

1977

Rattus norvegicus

893439

390752

Bernert, J.T.; Sprecher, H.

The isolation of acyl-CoA derivatives as products of partial reactions in the microsomal chain elongation of fatty acids

Biochim. Biophys. Acta

573

436-442

1979

Rattus norvegicus

37916

390753

Prasad, M.R.; Chiang, C.F.; Cook, L.; Cinti, D.L.

Solubilization and purification of hepatic microsomal trans-2-enoyl-CoA reductase: evidence for the existence of a second long-chain enoyl-CoA reductase

Arch. Biochem. Biophys.

237

535-544

1985

Rattus norvegicus

3977322

390754

Nagi, M.N.; Prasad, M.R.; Cook, L.; Cinti, D.

Biochemical properties of short- and long-chain rat liver microsomal trans-2-enoyl coenzyme A reductase

Arch. Biochem. Biophys.

226

50-64

1983

Rattus norvegicus

6416174

390755

Prasad, M.R.; Nagi, M.N.; Cook, L.; Cinti, D.L.

Kinetic evidence for two separate trans-2-enoyl CoA reductases in rat hepatic microsomes: NADPH-specific short chain- and NAD(P)H-dependent long chain-reductase

Biochem. Biophys. Res. Commun.

113

659-665

1983

Rattus norvegicus

6870879

390756

Cinti, D.L.; Nagi, M.N.; Cook, L.; White, R.E.

Evidence for a second microsomal trans-2-enoyl coenzyme A reductase in rat liver. NADPH-specific short chain reductase

J. Biol. Chem.

257

14333-14340

1982

Rattus norvegicus

6815194

390757

Nagi, M.N.; Cook, L.; Ghesquier, D.; Cinti, D.L.

Site of inhibition of rat liver microsomal fatty acid chain elongation system by dec-2-ynoyl coenzyme A. Possible mechanism of inhibition

J. Biol. Chem.

261

13598-13605

1986

Rattus norvegicus

3759985

390758

Nagi, M.N.; Cook, L.; Laguna, J.C.; Cinti, D.L.

Dual action of 2-decynoyl coenzyme A: inhibitor of hepatic mitochondrial trans-2-enoyl coenzyme A reductase and peroxisomal bifunctional protein and substrate for the mitochondrial beta-oxidation system

Arch. Biochem. Biophys.

267

1-12

1988

Rattus norvegicus

3058034

390759

Laguna, J.C.; Nagi, M.; Cook, L.; Cinti, D.L.

Action of Ebselen on rat hepatic microsomal enzyme-catalyzed fatty acid chain elongation, desaturation, and drug biotransformation

Arch. Biochem. Biophys.

269

272-283

1989

Rattus norvegicus

2563645

390810

Inui, H.; Miyatake, K.; Nakano, Y.; Kitaoka, S.

Fatty acid synthesis in mitochondria of Euglena gracilis

Eur. J. Biochem.

142

121-126

1984

Euglena gracilis

6146525

390849

Kikuchi, S.; Kusaka, T.

Purification of NADPH-dependent enoyl-CoA reductase involved in the malonyl-CoA dependent fatty acid elongation system of Mycobacterium smegmatis

J. Biochem.

841-848

1984

Mycolicibacterium smegmatis

6501266

390850

Strom, K.A.; Kumar, S.

Activation and inhibition of crotonyl-coenzyme A reductase activity of bovine mammary fatty acid synthetase

J. Biol. Chem.

254

8159-8162

1979

Bos taurus

390851

Strom, K.A.; Galeos, W.L.; Davidson, L.A.; Kumar, S.

Enoyl coenzyme A reduction by bovine mammary fatty acid synthetase. Specificity and other characteristics

J. Biol. Chem.

254

8153-8158

1979

Bos taurus

468815

390852

Maitra, S.K.; Kumar, S.

Crotonyl coenzyme A reductase activity of bovine mammary fatty acid synthetase

J. Biol. Chem.

249

111-117

1974

Bos taurus

4149043

390853

Ishidate, K.; Mizugaki, M.; Uchiyama, M.

Induction of NADPH enoyl-coA reductase in Candida grown in the presence of unsaturated fatty acids

J. Biochem.

1139-1142

1974

Candida albicans

4616030

390854

Ishidate, K.; Mizugaki, M.; Uchiyama, M.

Separation and some characterizations of NADPH-enoyl CoA reductase(s) from Candida albicans

Chem. Pharm. Bull.

2685-2691

1974

Candida albicans

4619583

390855

Mizugaki, M.; Uchiyama, M.

Stereospecific hydrogen transfer by NADPH-enoyl coenzyme A reductase to cis- and trans-isomers of 2-enoic acid

J. Biochem.

691-696

1973

Rattus norvegicus

4763659

390856

Mizugaki, M.; Uchiyama, M.

Possible role of NADPH-dependent enoyl coenzyme A reductase in -oxidation of unsaturated fatty acids

Biochem. Biophys. Res. Commun.

48-53

1973

Rattus norvegicus

4405232

390857

Podack, E.R.; Seubert, W.

On the mechanism of malonyl-CoA independent fatty acid synthesis. II. Isolation, properties and subcellular location of trans-2,3-hexenoyl-CoA and trans-2,3-decenoyl-CoA reductase

Biochim. Biophys. Acta

280

235-247

1972

Rattus norvegicus

4404888

390858

Seubert, W.; Lamberts, I.; Kramer, R.; Ohly, B.

On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA

Biochim. Biophys. Acta

164

498-517

1968

Rattus norvegicus

4387390

390868

Mukherjee, S.; Katiyar, S.S.

Evidence for the essential histidine at the NADPH binding site of enoyl-CoA reductase domain of pigeon liver fatty acid synthetase

J. Enzyme Inhib.

209-216

1997

Columba sp.

9204389

390869

Mukherjee, S.; Katiyar, S.S.

Inactivation of enoyl-CoA reductase in pigeon liver fatty acid synthetase by pyridoxal 5'-phosphate. Evidence for the presence of one lysine residue at the active site

J. Enzyme Inhib.

217-228

1998

Columba sp.

9629539

390870

Cvetanovic, M.; Moreno de la Garza, M.; Dommes, V.; Kunau, W.H.

Purification and characterization of 2-enoyl-CoA-reductase from bovine liver

Biochem. J.

227

49-56

1985

Bos taurus

3994691

390872

Sargueil, F.; Knoll, A.; Salles, J.; Garbay, B.; Cassagne, C.

High metabolism and subsequent elongation of 3-hydroxyeicosanoyl-CoA in very-long- chain fatty acid deficient PNS of Trembler mice

Neurosci. Lett.

273

29-32

1999

Mus musculus

10505644

390873

Lessire, R.; Chevalier, S.; Lucet-Levannier, K.; Lellouche, J.P.; Mioskowski, C.; Cassagne, C.

Study of the 3-hydroxy-eicosanoyl-coenzyme A dehydratase and (E)-2,3 enoyl-coenzyme A reductase involved in acyl-coenzyme A elongation in etiolated leek seedlings

Plant Physiol.

119

1009-1015

1999

Allium ampeloprasum

10069838

656737

Li, C.; Florova, G.; Akopiants, K.; Reynolds, K.A.

Crotonyl-coenzyme A reductase provides methylmalonyl-CoA precursors for monensin biosynthesis by Streptomyces cinnamonensis in an oil-based extended fermentation

Microbiology

150

3463-3472

2004

Streptomyces collinus

15470123

673619

Park, J.; Kim, T.; Kim, S.; Kim, W.T.; Pai, H.

Silencing of NbECR encoding a putative enoyl-CoA reductase results in disorganized membrane structures and epidermal cell ablation in Nicotiana benthamiana

FEBS Lett.

579

4459-4464

2005

Nicotiana benthamiana (Q3IAA0), Nicotiana benthamiana

16081072

685980

Rennison, J.H.; McElfresh, T.A.; Okere, I.C.; Patel, H.V.; Foster, A.B.; Patel, K.K.; Stoll, M.S.; Minkler, P.E.; Fujioka, H.; Hoit, B.D.; Young, M.E.; Hoppel, C.L.; Chandler, M.P.

Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failure

Cardiovasc. Res.

331-340

2008

Rattus norvegicus

18339649

689745

Erb, T.J.; Berg, I.A.; Brecht, V.; Mueller, M.; Fuchs, G.; Alber, B.E.

Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway

Proc. Natl. Acad. Sci. USA

104

10631-10636

2007

Cereibacter sphaeroides

17548827

712769

Sugishima, M.; Okamoto, Y.; Noguchi, M.; Kohchi, T.; Tamiaki, H.; Fukuyama, K.

Crystal structures of the substrate-bound forms of red chlorophyll catabolite reductase: implications for site-specific and stereospecific reaction

J. Mol. Biol.

402

879-891

2010

Arabidopsis thaliana

20727901