1.3.1.8: acyl-CoA dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about acyl-CoA dehydrogenase (NADP+), go to the full flat file.
Word Map on EC 1.3.1.8
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1.3.1.8
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enoyl-coas
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acyl-coas
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crotonyl-coa
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very-long-chain
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vlcfas
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butyryl-coa
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dehydrase
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3-hydroxyacyl-coa
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beta-hydroxyacyl-coa
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decanoyl-coa
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acetyl-coa-dependent
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octanoyl-coa
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elongase
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leek
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nadph-specific
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collinus
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trans-enoyl-coas
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synthesis
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biotechnology
- 1.3.1.8
- enoyl-coas
- acyl-coas
- crotonyl-coa
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very-long-chain
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vlcfas
- butyryl-coa
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dehydrase
- 3-hydroxyacyl-coa
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beta-hydroxyacyl-coa
- decanoyl-coa
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acetyl-coa-dependent
- octanoyl-coa
- elongase
- leek
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nadph-specific
- collinus
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trans-enoyl-coas
- synthesis
- biotechnology
Reaction
Synonyms
2-enoyl-CoA reductase, 2-trans enoyl-CoA reductase, 2-trans-enoyl-CoA reductase, acyl coenzyme A dehydrogenase (nicotinamide adenine dinucleotide phosphate), CCR, crotonyl CoA reductase, crotonyl coenzyme A reductase, crotonyl-CoA reductase, crotonyl-coenzyme A reductase, dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate), enoyl coenzyme A reductase, enoyl-CoA reductase, MCAD, medium-chain acyl-CoA dehydrogenase, NADPH:enoyl-CoA oxidoreductase, NbECR, RCCR, trans-2-enoyl-CoA reductase
ECTree
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Substrates Products
Substrates Products on EC 1.3.1.8 - acyl-CoA dehydrogenase (NADP+)
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REACTION DIAGRAM
2-methyl-trans-crotonyl-CoA + NADPH
2-methylbutanoyl-CoA + NADP+
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2% of trans-crotonyl-CoA activity
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-
?
2-trans-8,11-eicosatrienoyl-CoA + NADPH
8,11-eicosadienoyl-CoA + NADP+
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fat-free dietary elevates the activity
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?
3-butenoyl-CoA + NADPH
butanoyl-CoA + NADP+
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7% of trans-crotonyl-CoA activity
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-
?
3-methyl-crotonyl-CoA + NADPH
3-methylbutanoyl-CoA + NADP+
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17% of trans-crotonyl-CoA activity
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-
?
5-hydroxyundec-cis-2-enoyl-CoA + NADPH
5-hydroxyundecanoyl-CoA + NADP+
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-
-
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?
6,9-octadecadienoyl-CoA + NADPH
?
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fat-free dietary elevates the activity
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-
?
primary fluorescent chlorophyll catabolite + NADP+
red chlorophyll catabolite + NADPH + H+
2-cis-octenoyl-CoA + NADPH
octanoyl-CoA + NADP+
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substrate is not specified as cis- or trans-octenoyl-CoA
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-
?
2-trans-decenoyl-CoA + NAD(P)H
decanoyl-CoA + NADP+
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mitochondrial reductase II shows high activity, cofactor NADH
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-
?
2-trans-dodecenoyl-CoA + NAD(P)H
dodecanoyl-CoA + NAD(P)+
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15% of trans-crotonyl-CoA activity
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-
?
2-trans-dodecenoyl-CoA + NAD(P)H
dodecanoyl-CoA + NAD(P)+
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mitochondrial reductases II and III, low activity, cofactor NADH for isoform II and NADH or NADPH for isoform III
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-
?
hexadecanoyl CoA + NADP+
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13% of trans-crotonyl-CoA activity
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-
?
2-trans-hexadecenoyl-CoA + NADPH
hexadecanoyl CoA + NADP+
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-
-
-
?
2-trans-hexenoyl-CoA + NAD(P)H
hexanoyl-CoA + NADP+
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30% of trans-crotonyl-CoA activity
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-
?
2-trans-hexenoyl-CoA + NAD(P)H
hexanoyl-CoA + NADP+
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mitochondrial enzymes, reductase III shows highest activity, reductase I shows 45% activity of that with crotonyl-CoA, reductase II shows lower activity, cofactor NADH for isoform I and II and NADH or NADPH for isoform III
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-
?
octadecanoyl-CoA + NAD(P)+
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cofactor NADH, mitochondrial reductase I shows 25% activity of that with crotonyl-CoA, reductase II shows highest activity
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-
?
2-trans-octadecenoyl-CoA + NAD(P)H
octadecanoyl-CoA + NAD(P)+
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i.e. 2-trans-oleoyl-CoA
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-
?
2-trans-octenoyl-CoA + NAD(P)H
octanoyl-CoA + NADP+
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mitochondrial enzyme, NADH-specific reaction
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-
?
2-trans-octenoyl-CoA + NAD(P)H
octanoyl-CoA + NADP+
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substrate is not specified as cis- or trans-octenoyl-CoA
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-
?
2-trans-octenoyl-CoA + NAD(P)H
octanoyl-CoA + NADP+
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trans isomer exhibits 1/3 of activity of cis isomer
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-
?
crotonyl-CoA + NAD(P)H
butanoyl-CoA + NADP+
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cis-crotonyl-CoA 30% of trans-crotonyl-CoA activity
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-
?
crotonyl-CoA + NAD(P)H
butanoyl-CoA + NADP+
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mitochondrial reductase I, no specification of stereoisomer, cofactor NADH
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-
?
butyryl-CoA + oxidized acceptor
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-
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?
crotonyl-CoA + reduced acceptor
butyryl-CoA + oxidized acceptor
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enzyme is involved in synthesizing methylmalonyl-CoA precursors for monensin biosynthesis, pathway flux, overview
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-
?
red chlorophyll catabolite + NADPH + H+
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stereospecific reaction
red chlorophyll catabolite, RCC, binding does not drastically change the RCCR structure, binding structure and mechanism analysis, overview. Comparison of the RCC-binding pockets of wild-type RCCRDELTA49 and F218V RCCRDELTA49, overview
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r
primary fluorescent chlorophyll catabolite + NADP+
red chlorophyll catabolite + NADPH + H+
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stereospecific reaction. RCCR catalyzes the ferredoxin-dependent and site-specific reduction of the C20/C1 double bond of red chlorophyll catabolite, RCC, the catabolic intermediate produced in chlorophyll degradation
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-
r
trans-2-eicosenoyl-CoA + NADPH
eicosanoyl-CoA + NADP+
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enzyme is part of acyl-CoA elongase complex responsible for fatty acid elongation
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?
trans-2-eicosenoyl-CoA + NADPH
eicosanoyl-CoA + NADP+
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enzyme is part of acyl-CoA elongase complex responsible for fatty acid elongation
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?
trans-2-eicosenoyl-CoA + NADPH
eicosanoyl-CoA + NADP+
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enzyme activity is higher in neurological Trembler mouse mutant than in wild-type
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?
trans-2-eicosenoyl-CoA + NADPH
eicosanoyl-CoA + NADP+
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i.e. arachidoyl-CoA
?
additional information
?
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no cis-isomeric substrates tested, classification is not definite
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-
?
additional information
?
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no activity with acetoacetyl-CoA or (R)-3-hydroxybutyryl-CoA
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-
?
additional information
?
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mitochondrial reductase III uses substrate with chain length of C4-C12
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?
additional information
?
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no cis-isomeric substrates tested, classification is not definite
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?
additional information
?
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active as part of fatty acid synthetase by incorporation of acetyl-CoA in mitochondria and of malonyl-CoA in cytosol
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?
additional information
?
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very slow reduction of substrate with chain length C4, C10, C12
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?
additional information
?
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FMN is essential for the reaction, tightly bound to apoprotein
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?
additional information
?
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involvement in malonyl-CoA fatty acid elongation system II
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?
additional information
?
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the enzyme catalyzes the last step in synthesis of very long fatty acid. NbECR activity is essential for membrane biogenesis. Loss of NbECR function affects biogenesis of cellular membranes including the plasma membrane and the thylakoid membrane
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?
additional information
?
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the enzyme catalyzes the last step in synthesis of very long fatty acid. NbECR activity is essential for membrane biogenesis. Loss of NbECR function affects biogenesis of cellular membranes including the plasma membrane and the thylakoid membrane
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?
additional information
?
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NADPH specific trans-enoyl-CoA reductases isolated from rat liver microsomes and mitochondria impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates
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-
?
additional information
?
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NADPH specific trans-enoyl-CoA reductases isolated from rat liver microsomes and mitochondria impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates
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-
?
additional information
?
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NADPH specific trans-enoyl-CoA reductases isolated from rat liver microsomes and mitochondria impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates
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-
?
additional information
?
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NADPH specific trans-enoyl-CoA reductases isolated from rat liver microsomes and mitochondria impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates
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-
?
additional information
?
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NADPH specific trans-enoyl-CoA reductases isolated from rat liver microsomes and mitochondria impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates
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-
?
additional information
?
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NADPH specific trans-enoyl-CoA reductases isolated from rat liver microsomes and mitochondria impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates
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-
?
additional information
?
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NADPH specific trans-enoyl-CoA reductases isolated from rat liver microsomes and mitochondria impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates
-
-
?
additional information
?
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NADPH specific trans-enoyl-CoA reductases isolated from rat liver microsomes and mitochondria impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates
-
-
?
additional information
?
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NADPH specific trans-enoyl-CoA reductases isolated from rat liver microsomes and mitochondria impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates
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-
?
additional information
?
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specific for alpha/beta-unsaturated CoA derivatives with chain lengths of 4-16 C atoms, neither involved in beta-oxidation of fatty acids nor de novo-synthesis of fatty acids via malonyl-CoA
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?
additional information
?
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involvement in malonyl-CoA fatty acid elongation system II
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?
additional information
?
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involvement in malonyl-CoA fatty acid elongation system II
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?